Susan Hoover, MD, FACS

Cancer Focus:
Breast Cancer, Ductal Carcinoma In Situ, Inflammatory Breast Cancer, Invasive Ductal Carcinoma, Triple Negative Breast Cancer

Dr. Susan Hoover is a board certified surgical oncologist specializing in breast cancer in the Moffitt Cancer Center Department of Breast Oncology. Additionally, Dr. Hoover is the Breast Surgical Oncology Fellowship Program Director. She returned to Moffitt after several years of practice at the MD Anderson Cancer Center in Houston, Texas. In addition to performing breast surgeries, such as mastectomies and lumpectomies, she has special expertise in minimally-invasive surgery techniques, incorporating sentinel lymph node biopsy, breast ultrasound, breast needle biopsy and accelerated partial breast irradiation into her patient care. Dr. Hoover has held national committee appointments in the Society for Surgical Oncology, the American Society of Breast Surgeons and the Association of Women Surgeons. She has been chosen by her peers for listing in Best Doctors in America® since 2009.

 

Education & Training

Fellowship:

• University of Texas Southwestern, Dallas, TX - Breast Fellowship

Residency:

• University of Texas Southwestern, Dallas, TX - General Surgery

Medical School:

• University of Texas Southwestern, Dallas, TX - MD

• Baumrucker C, Aiello P, Harris N, Whiting J, Funaro K, Hoover S, Kiluk J, Kruper L, Mallory M, Khakpour N, Laronga C, Czerniecki BJ, Lee MC, Detz D. Identifying Axillary Metastases in Patients with T3 Invasive Lobular Carcinoma. South Med J. 2025 Oct.118(10):687-691. Pubmedid: 41072035.
• Soliman H, Aldrich A, Abdo N, Han H, Soyano A, Costa R, Armaghani A, Kiluk J, Khakpour N, Lee MC, Hoover S, Laronga C, Niell B, Mooney B, Weinfurtner RJ, Rosa M, Czerniecki B. A pilot study incorporating HER2-directed dendritic cells into neoadjuvant therapy of early stage HER2+ER- breast cancer. NPJ Breast Cancer. 2025 Mar.11(1):29. Pubmedid: 40097486. Pmcid: PMC11914126.
• Sauls RM, Buro AW, Brown N, Riccardi D, Mallory M, Hoover S, Laronga C, Pabbathi S, Carson TL. Lifestyle Behaviors and Needs After Breast Cancer Diagnosis: A Qualitative Assessment. Am J Health Promot. 2025 Jan.39(1):76-88. Pubmedid: 39033310.
• Han HS, Aldrich AL, Garg SK, Weinfurtner RJ, Nguyen JV, Mo Q, Whiting J, Childress J, Soliman H, Costa R, Armaghani A, Soyano A, Kiluk J, Hoover S, Lee MC, Khakpour N, Shenoi N, Jameel Z, Koski GK, Czerniecki BJ. Alteration of the Tumor Microenvironment With Intratumoral Dendritic Cells Before Chemotherapy in ERBB2 Breast Cancer: A Nonrandomized Clinical Trial. JAMA Oncol. 2025 Feb.11(2):119-127. Pubmedid: 39636623. Pmcid: PMC11622104.
• Baumrucker CC, Harris N, Hoover S, Czerniecki BJ. Intratumoral Immunotherapy in Breast Cancer. Vaccines (Basel). 2025 Apr.13(4). Pubmedid: 40333343. Pmcid: PMC12031351.
• Detz D, Hanssen D, Whiting J, Sun W, Czerniecki B, Hoover S, Khakpour N, Kiluk J, Laronga C, Mallory M, Lee MC, Kruper L. Retrieval of the Clipped Axillary Lymph Node and Its Impact on Treatment Decisions. Cancers (Basel). 2024 Aug.16(17). Pubmedid: 39272859. Pmcid: PMC11393888.
• Champion NT, Mooney B, Kim Y, Whiting J, Sun W, Kiluk J, Czerniecki B, Hoover S, Lee MC. Surgeon and Radiologist Evaluation of Electromagnetic Chip Localization for Benign and Malignant Breast Lesions. Ann Surg Oncol. 2023 Nov.30(12):7081-7090. Pubmedid: 37552349.
• Hedges EA, Khan TM, Teke M, Wach MM, Hernandez JM, Hoover SJ. Breast Surgical Oncology Fellowship applicant selection and ranking: A survey of Society of Surgical Oncology programs. J Surg Oncol. 2023 Jan.127(1):34-39. Pubmedid: 36181515.
• Soliman H, Hogue D, Han H, Mooney B, Costa R, Lee MC, Niell B, Williams A, Chau A, Falcon S, Soyano A, Armaghani A, Khakpour N, Weinfurtner RJ, Hoover S, Kiluk J, Laronga C, Rosa M, Khong H, Czerniecki B. Oncolytic T-VEC virotherapy plus neoadjuvant chemotherapy in nonmetastatic triple-negative breast cancer: a phase 2 trial. Nat Med. 2023 Feb.29(2):450-457. Pubmedid: 36759673.
• Elleson KM, Englander K, Gallagher J, Chintapally N, Sun W, Whiting J, Mallory M, Kiluk J, Hoover S, Khakpour N, Czerniecki B, Laronga C, Lee MC. Factors Predictive of Positive Lymph Nodes for Breast Cancer. Curr Oncol. 2023 Dec.30(12):10351-10362. Pubmedid: 38132388. Pmcid: PMC10742655.
• Soliman H, Hogue D, Han H, Mooney B, Costa R, Lee MC, Niell B, Williams A, Chau A, Falcon S, Soyano A, Armaghani A, Khakpour N, Weinfurtner RJ, Hoover S, Kiluk J, Laronga C, Rosa M, Khong H, Czerniecki B. Author Correction: Oncolytic T-VEC virotherapy plus neoadjuvant chemotherapy in nonmetastatic triple-negative breast cancer: a phase 2 trial. Nat Med. 2023 Dec.29(12):3270. Pubmedid: 36932246.
• Champion NT, Mooney B, Kim Y, Whiting J, Sun W, Kiluk J, Czerniecki B, Hoover S, Lee MC. ASO Visual Abstract: Surgeon and Radiologist Evaluation of Electromagnetic Chip Localization for Benign and Malignant Breast Lesions. Ann Surg Oncol. 2023 Dec.30(13):8478. Pubmedid: 37679539.
• Barker VR, Naffouje SA, Mallory MA, Hoover SA, Laronga C. Surgical Management of the Axilla in HR+/HER2- Breast Cancer in the Z1071 Era: A Propensity Score-Matched Analysis of the National Cancer Database. Ann Surg Oncol. 2023 Dec.30(13):8371-8380. Pubmedid: 37610487.
• Sinner HF, Naffouje S, Selfridge JM, Lee MC, Hoover SJ, Laronga C. Surgical Management of the Axilla in Invasive Lobular Carcinoma in the Z1071 Era: A Propensity-Score Matched Analysis of the National Cancer Database. Curr Oncol. 2022 Oct.29(11):8197-8206. Pubmedid: 36354707. Pmcid: PMC9689286.
• Naffouje SA, Barker V, Lee MC, Hoover SJ, Laronga C. ASO Visual Abstract: Surgical Management of the Axilla of Triple-Negative Breast Cancer in the Z1071 Era-A Propensity-Score Matched Analysis of the National Cancer Database. Ann Surg Oncol. 2022 May.29(5):2998-2999. Pubmedid: 35076771.
• Naffouje SA, Barker V, Lee MC, Hoover SJ, Laronga C. Surgical Management of Axilla of Triple-Negative Breast Cancer in the Z1071 Era: A Propensity Score-Matched Analysis of the National Cancer Database. Ann Surg Oncol. 2022 May.29(5):2985-2997. Pubmedid: 35006503.
• Selfridge JM, Sinner HF, Whiting J, Sun W, Mallory MA, Hoover SJ, Kiluk JV, Khakpour N, Czerniecki BJ, Laronga C, Mo Q, Lee MC. Effect of Microporous Polysaccharide Particles in Patients Undergoing Mastectomy. Clin Breast Cancer. 2022 Dec.22(8):e922-e927. Pubmedid: 36055918.
• Sun J, Zhong X, Ma J, Sun W, Han HS, Soliman HH, Loftus LS, Costa RLB, Armaghani AJ, Soyano-Muller AE, Czerniecki BJ, Lee MC, Kiluk JV, Khakpour N, Hoover SJ, Laronga C, Khong HT. Real-world benefit of combination palbociclib and endocrine therapy for metastatic breast cancer and correlation with neutropenia. Cancer Med. 2021 Nov.10(21):7665-7672. Pubmedid: 34590788. Pmcid: PMC8559460.
• Sun J, Henry DA, Carr MJ, Yazdankhahkenary A, Laronga C, Lee MC, Hoover SJ, Sun W, Czerniecki BJ, Khakpour N, Kiluk JV. Feasibility of Axillary Lymph Node Localization and Excision Using Radar Reflector Localization. Clin Breast Cancer. 2021 Jun.21(3):e189-e193. Pubmedid: 32893094.
• Parikh P, Jameel Z, Falcon S, Rosa M, Kiluk J, Hoover S, Soliman H, Ataya D. Adenomyoepithelioma of the breast: Case series and literature review. Clin Imaging. 2021 Jul.75:157-164. Pubmedid: 33607537.
• Soliman H, Hogue D, Han HS, Mooney B, Lima Barros Costa R, Lee MC, Niell B, Williams A, Chau A, Falcon S, Khakpour N, Weinfurtner RJ, Hoover S, Kiluk J, Rosa M, Khong H, Czerniecki BJ. A Phase I Trial of Talimogene Laherparepvec in Combination with Neoadjuvant Chemotherapy for the Treatment of Nonmetastatic Triple-Negative Breast Cancer. Clin Cancer Res. 2021 Feb.27(4):1012-1018. Pubmedid: 33219014.
• Naffouje SA, Sabesan A, Hoover SJ, Lee MC, Laronga C. ASO Visual Abstract: Surgical Management of the Axilla of HER2+ Breast Cancer in the Z1071 Era: A Propensity-Score Matched Analysis of the National Cancer Database. Ann Surg Oncol. 2021 Dec.28(Suppl 3):581-582. Pubmedid: 34363117.
• Naffouje SA, Sabesan A, Hoover SJ, Lee MC, Laronga C. Surgical Management of the Axilla of HER2+ Breast Cancer in the Z1071 Era: A Propensity-Score-Matched Analysis of the NCDB. Ann Surg Oncol. 2021 Dec.28(13):8777-8788. Pubmedid: 34258723.
• Rajarajan N, Mariotti V, Basu A, Kodumudi K, Han H, Czerniecki B, Hoover S. Strategies to Combat Human Epidermal Growth Factor Receptor 2 (HER2) Resistance in HER2-Positive Breast Cancer. Crit Rev Oncog. 2020 Jul.25(3):209-231. Pubmedid: 33463942.
• Burke EE, Laronga C, Sun W, DeBiase S, Naqvi SMH, Fridley B, Czerniecki BJ, Hoover SJ, Khakpour N, Kiluk JV, Lee MC. Implant-sparing Mastectomy: An Alternative for Women Undergoing Mastectomy With Retropectoral Implants. Clin Breast Cancer. 2020 Feb.20(1):e14-e19. Pubmedid: 31780380. Pmcid: PMC7771331.
• Mills MN, Yang GQ, Oliver DE, Liveringhouse CL, Ahmed KA, Orman AG, Laronga C, Hoover SJ, Khakpour N, Costa RLB, Diaz R. Histologic heterogeneity of triple negative breast cancer: A National Cancer Centre Database analysis. Eur J Cancer. 2018 Jul.98:48-58. Pubmedid: 29870876.
• Mattingly AE, Ma Z, Smith PD, Kiluk JV, Khakpour N, Hoover SJ, Laronga C, Lee MC. Early Postoperative Complications after Oncoplastic Reduction. South Med J. 2017 Oct.110(10):660-666. Pubmedid: 28973708. Pmcid: PMC7771341.
• Mattingly AE, Mooney B, Lin HY, Kiluk JV, Khakpour N, Hoover SJ, Laronga C, Lee MC. Magnetic Resonance Imaging for Axillary Breast Cancer Metastasis in the Neoadjuvant Setting: A Prospective Study. Clin Breast Cancer. 2017 Jun.17(3):180-187. Pubmedid: 27956116.
• Mellon EA, Orman A, Joya LE, Montejo ME, Laronga C, Hoover SJ, Lee MC, Khakpour N, Kubal PF, Diaz R. Frequency of whole breast radiation therapy after intraoperative radiation therapy due to criteria identified by lumpectomy. Brachytherapy. 2017 Jul.16(1):174-180. Pubmedid: 27816540.
• Khazai L, Chau A, Hoover S, Rosa M. Papillary endothelial hyperplasia arising in the irradiated breast: A diagnostic dilemma. Pathol Res Pract. 2016 Jul.212(7):604-607. Pubmedid: 27157404.
• Zimmerman A, Locke FL, Emole J, Rosa M, Horna P, Hoover S, Dayicioglu D. Recurrent Systemic Anaplastic Lymphoma Kinase-Negative Anaplastic Large Cell Lymphoma Presenting as a Breast Implant-Associated Lesion. Cancer Control. 2015 Jul.22(3):369-373. Pubmedid: 26351895.
• Jafarian N, Kuppler K, Rosa M, Hoover S, Patel B. Chronic Lymphocytic Leukemia and Invasive Ductal Carcinoma Presenting as a Collision Breast Tumor. Clin Breast Cancer. 2015 Aug.15(4):e209-e212. Pubmedid: 25818398.
• Hoover S, Bloom E, Patel S. Review of breast conservation therapy: then and now. ISRN Oncol. 2012 Aug.2011:617593. Pubmedid: 22229101. Pmcid: PMC3200284.
• Sarnaik AA, Meade T, King J, Acs G, Hoover S, Cox CE, Carter WB, Laronga C. Adenoid cystic carcinoma of the breast: a review of a single institution's experience. Breast J. 2010 May.16(2):208-210. Pubmedid: 20030648.
• Laronga C, Lee MC, McGuire KP, Meade T, Carter WB, Hoover S, Cox CE. Indications for sentinel lymph node biopsy in the setting of prophylactic mastectomy. J Am Coll Surg. 2009 Dec.209(6):746-752. Pubmedid: 19959044.
• Hoover SJ, Berry MP, Rossick L, Rege RV, Jones DB. Ultrasound-guided breast biopsy curriculum for surgical residents. Surg Innov. 2008 Mar.15(1):52-58. Pubmedid: 18407929.
• Kiluk J, Acs G, Hoover S. High-risk benign breast lesions: current strategies in management. Cancer Control. 2007 Oct.14(4):321-329. Pubmedid: 17914332.
• Laronga C, Hasson D, Hoover S, Cox J, Cantor A, Cox C, Carter W. Paget's disease in the era of sentinel lymph node biopsy. Am J Surg. 2006 Oct.192(4):481-483. Pubmedid: 16978954.
• Bevers TB, Anderson BO, Bonaccio E, Borgen PI, Buys S, Daly MB, Dempsey PJ, Farrar WB, Fleming I, Garber JE, Harris RE, Helvie M, Hoover S, Krontiras H, Shaw S, Singletary E, Sugg Skinner C, Smith ML, Tsangaris TN, Wiley EL, Williams C. Breast cancer screening and diagnosis. J Natl Compr Canc Ne. 2006 May.4(5):480-508. Pubmedid: 16687096.
• Johnson-Maddux A, Ashfaq R, Cler L, Naftalis E, Leitch AM, Hoover S, Euhus DM. Reproducibility of cytologic atypia in repeat nipple duct lavage. Cancer. 2005 Mar.103(6):1129-1136. Pubmedid: 15685620.
• Maddux AJ, Ashfaq R, Naftalis E, Leitch AM, Hoover S, Euhus D. Patient and duct selection for nipple duct lavage. Am J Surg. 2004 Oct.188(4):390-394. Pubmedid: 15474432.
• Meng S, Tripathy D, Shete S, Ashfaq R, Haley B, Perkins S, Beitsch P, Khan A, Euhus D, Osborne C, Frenkel E, Hoover S, Leitch M, Clifford E, Vitetta E, Morrison L, Herlyn D, Terstappen LW, Fleming T, Fehm T, Tucker T, Lane N, Wang J, Uhr J. HER-2 gene amplification can be acquired as breast cancer progresses. Proc Natl Acad Sci U S A. 2004 Jun.101(25):9393-9398. Pubmedid: 15194824. Pmcid: PMC438987.
• Meng S, Tripathy D, Frenkel EP, Shete S, Naftalis EZ, Huth JF, Beitsch PD, Leitch M, Hoover S, Euhus D, Haley B, Morrison L, Fleming TP, Herlyn D, Terstappen LW, Fehm T, Tucker TF, Lane N, Wang J, Uhr JW. Circulating tumor cells in patients with breast cancer dormancy. Clin Cancer Res. 2004 Dec.10(24):8152-8162. Pubmedid: 15623589.

Voted top doctor in Breast Cancer Surgery in Tampa Magazine’s Top Doctors 2025.

Voted top doctor in Breast Cancer Surgery in Tampa Magazine’s Top Doctors 2024.