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Andrew  Sinnamon

Andrew Sinnamon, MD

4.9 (157)

Specialty: Surgery

Program: Gastrointestinal Oncology

Language(s): English

  • Overview

    Cancer Focus:
    Esophageal Cancer, Gastrointestinal Carcinoid Tumor, Neuroendocrine Tumor, Pancreatic Cancer, Stomach (Gastric) Cancer

    Dr. Andrew Sinnamon is a Surgical Oncologist within the Department of Gastrointestinal Oncology at Moffitt Cancer Center. He completed both medical school and General Surgery residency training at the University of Pennsylvania School of Medicine. During residency he completed a research fellowship studying outcomes for surgical oncology patients. He also obtained a Masters in Clinical Epidemiology during this time. Dr. Sinnamon then completed further fellowship training in Complex General Surgical Oncology at Moffitt, and has since joined the Department of Gastrointestinal Oncology.Dr. Sinnamon’s clinical interests include caring for patients with diseases of the pancreas, stomach, and esophagus. He has had formal training in the use of using minimally invasive robotic and laparoscopic techniques and is interested in using these approaches whenever possible to accelerate recovery after surgery. Dr. Sinnamon’s research efforts are focused on defining surgical and oncologic outcomes in gastroesophageal and pancreatic cancer in order to better select patients for surgery and additional therapies. He has published numerous peer-reviewed manuscripts and presents regularly at national meetings. He is a member of the Society of Surgical Oncology, Americas Hepato-Pancreato-Biliary Association, and the American College of Surgeons.

    Education & Training


    • H. Lee Moffitt Cancer Center and Research Institute -


    • University of Pennsylvania Perelman School of Medicine - Surgical Research Fellowship

    Medical School:

    • University of Pennsylvania Perelman School of Medicine - MD Degree
  • Publications

    • Read MD, Drake J, Hashemipour G, Powers BD, Mehta R, Sinnamon A, Pimiento JM, Dineen SP. Initial Experience Using Laparoscopic HIPEC for Gastric Cancer with Peritoneal Metastasis: Safety and Outcomes. Ann Surg Oncol. 2024 Jun.31(6):3750-3757. Pubmedid: 38430428.
    • Read MD, Drake J, Hashemipour G, Powers BD, Mehta R, Sinnamon A, Pimiento JM, Dineen SP. ASO Visual Abstract: Initial Experience with Laparoscopic HIPEC for Gastric Cancer with Peritoneal Metastasis-Safety and Outcomes. Ann Surg Oncol. 2024 Jul.31(7):4745-4746. Pubmedid: 38634961.
    • Drake JA, Sinnamon AJ, Saeed S, Mehta R, Palm RF, Baldonado JJ, Fontaine JP, Pimiento JM. Totally minimally invasive laparoscopic robot-assisted Ivor Lewis esophagectomy: improved technique and outcomes over 200 cases. J Gastrointest Oncol. 2024 Apr.15(2):544-554. Pubmedid: 38756649. Pmcid: PMC11094488.
    • Sharon CE, Tortorello GN, Ma K, Sinnamon AJ, Mitchell TC, Karakousis GC, Miura JT. Impact of Adjuvant Immunotherapy on Overall Survival in a Contemporary Cohort of Patients with Stage III Melanoma. Ann Surg Oncol. 2023 Sep.30(9):5329-5332. Pubmedid: 37332026.
    • Sinnamon AJ, Mehta R, Saeed S, Lauwers GY, Palm RF, Frakes JM, Hoffe SE, Baldonado JJ, Fontaine JP, Pimiento JM. Induction Fluorouracil-Based Chemotherapy and PET-Adapted Consolidation Chemoradiation with Esophagectomy for High-Risk Gastroesophageal Adenocarcinoma. Cancers (Basel). 2023 Sep.15(17). Pubmedid: 37686650. Pmcid: PMC10486661.
    • Sinnamon AJ, Anaya DA. ASO Author Reflections: Simultaneous Hepatic and Visceral Resection-A Bird in the Hand or Two in the Bush?. Ann Surg Oncol. 2023 Mar.30(3):1784-1785. Pubmedid: 36528746.
    • Mehta R, Sinnamon A, Dam A, Walko C, Palm R, Barton L, Lauwers G, Pimiento JM. Locally advanced mismatch repair-deficient gastroesophageal junction cancer: Diagnosis, treatment modifications, and monitoring. CA-Cancer J Clin. 2023 Mar.74(2):123-131. Pubmedid: 37849051.
    • Sinnamon AJ, Luo E, Xu A, Zhu S, Denbo JW, Fleming JB, Anaya DA. ASO Visual Abstract: Simultaneous Hepatic and Visceral Resection- Preoperative Risk Stratification and Implications on Return to Intended Oncologic Therapy. Ann Surg Oncol. 2023 Mar.30(3):1786. Pubmedid: 36459280.
    • Sinnamon AJ, Luo E, Xu A, Zhu S, Denbo JW, Fleming JB, Anaya DA. Simultaneous Hepatic and Visceral Resection: Preoperative Risk Stratification and Implications on Return to Intended Oncologic Therapy. Ann Surg Oncol. 2023 Mar.30(3):1772-1783. Pubmedid: 36418800.
    • Sinnamon AJ, Savoldy M, Mehta R, Dineen SP, Peña LR, Lauwers GY, Pimiento JM. ASO Visual Abstract: Tumor Regression Grade and Overall Survival Following Gastrectomy with Preoperative Therapy for Gastric Cancer. Ann Surg Oncol. 2023 Jun.30(6):3592-3593. Pubmedid: 36811737.
    • Sinnamon AJ, Savoldy M, Mehta R, Dineen SP, Peña LR, Lauwers GY, Pimiento JM. Tumor Regression Grade and Overall Survival following Gastrectomy with Preoperative Therapy for Gastric Cancer. Ann Surg Oncol. 2023 Jun.30(6):3580-3589. Pubmedid: 36765008.
    • Sinnamon AJ, Pimiento JM. ASO Author Reflections: Toward a Universal Definition of Tumor Regression Grade in Gastric Cancer. Ann Surg Oncol. 2023 Jun.30(6):3590-3591. Pubmedid: 36723724.
    • Shannon AB, Sharon CE, Straker RJ, Carr MJ, Sinnamon AJ, Bogatch K, Thaler A, Kelly N, Vetto JT, Fowler G, DePalo D, Sondak VK, Miura JT, Faries MB, Bartlett EK, Zager JS, Karakousis GC. Sentinel lymph node biopsy in patients with T1a cutaneous malignant melanoma: A multicenter cohort study. J Am Acad Dermatol. 2023 Jan.88(1):52-59. Pubmedid: 36184008.
    • Vega EA, Newhook TE, Mellado S, Ruzzenente A, Okuno M, De Bellis M, Panettieri E, Ahmad MU, Merlo I, Rojas J, De Rose AM, Nishino H, Sinnamon AJ, Donadon M, Hauger MS, Guevara OA, Munoz C, Denbo JW, Chun YS, Tran Cao HS, Sanchez Claria R, Tzeng CD, De Aretxabala X, Vivanco M, Brudvik KW, Seo S, Pekolj J, Poultsides GA, Torzilli G, Giuliante F, Anaya DA, Guglielmi A, Vinuela E, Vauthey JN. Benchmarks and Geographic Differences in Gallbladder Cancer Surgery: An International Multicenter Study. Ann Surg Oncol. 2023 Aug.30(8):4904-4911. Pubmedid: 37149547.
    • Sinnamon AJ, Luo E, Xu A, Zhu S, Denbo JW, Fleming JB, Anaya DA. Clockwise Anterior-to-Posterior-Double Isolation (CAP-DI) Approach for Portal Lymphadenectomy in Biliary Tract Cancer: Technique, Yield, and Outcomes. Cancers (Basel). 2022 Nov.14(23). Pubmedid: 36497252. Pmcid: PMC9738406.
    • Sinnamon AJ, Hodul PJ, Pimiento JM. Removing Barriers to Access Starts with a Phone Call: Impact of Pre-Visit Coordination of Care in Efficiency of Therapy and Patient and Provider Satisfaction. Ann Surg Oncol. 2022 Mar.29(3):1506-1508. Pubmedid: 34853937.
    • Sinnamon AJ, Wood AC, Satyadi MA, Levitt CV, Hardy O, Haider M, Kim RD, Anaya DA, Denbo JW. Anatomic patterns of recurrence in biliary tract cancers: does primary tumor site matter?. J Gastrointest Oncol. 2022 Jun.13(3):1413-1422. Pubmedid: 35837169. Pmcid: PMC9274032.
    • Straker RJ, Taylor LA, Neuwirth MG, Sinnamon AJ, Shannon AB, Abbott J, Miura JT, Chu EY, Xu X, Karakousis GC. Optimizing Detection of Lymphatic Invasion in Primary Cutaneous Melanoma With the Use of D2-40 and a Paired Melanocytic Marker. Am J Dermatopathxxx. 2022 Jan.44(1):21-27. Pubmedid: 34231497. Pmcid: PMC8671172.
    • Straker RJ, Carr MJ, Sinnamon AJ, Shannon AB, Sun J, Landa K, Baecher KM, Wood C, Lynch K, Bartels HG, Panchaud R, Lowe MC, Slingluff CL, Jameson MJ, Tsai K, Faries MB, Beasley GM, Sondak V, Karakousis GC, Zager JS, Miura JT. Predictors of False Negative Sentinel Lymph Node Biopsy in Clinically Localized Merkel Cell Carcinoma. Ann Surg Oncol. 2021 Nov.28(12):6995-7003. Pubmedid: 33890195.
    • Sinnamon AJ, Gimotty PA, Karakousis GC, Yang YX. Survival Outcomes Following Lymph Node Biopsy in Thin Melanoma-A Propensity-Matched Analysis. Ann Surg Oncol. 2021 Mar.28(3):1634-1641. Pubmedid: 32779048.
    • Folkert IW, Sinnamon AJ, Concors SJ, Bennett BJ, Fraker DL, Mahmoud NN, Metz DC, Stashek KM, Roses RE. Grade is a Dominant Risk Factor for Metastasis in Patients with Rectal Neuroendocrine Tumors. Ann Surg Oncol. 2020 Mar.27(3):855-863. Pubmedid: 31701298.
    • Concors SJ, Sinnamon AJ, Ecker BL, Metz DC, Vollmer CM, Fraker DL, Roses RE. The impact of surgery for metastatic pancreatic neuroendocrine tumor: a contemporary evaluation matching for chromogranin a level. HPB (Oxford). 2020 Jan.22(1):83-90. Pubmedid: 31239188.
    • Sinnamon AJ, Gimotty PA, Karakousis GC, Yang YX. ASO Author Reflection: Sentinel Lymph Node Biopsy in Thin Melanoma. Ann Surg Oncol. 2020 Dec.27(Suppl 3):901-902. Pubmedid: 32839901.
    • Sinnamon AJ, Neuwirth MG, Song Y, Schultz SM, Liu S, Xu X, Sehgal CM, Karakousis GC. Multispectral photoacoustic imaging for the detection of subclinical melanoma. J Surg Oncol. 2019 Jun.119(8):1070-1076. Pubmedid: 30874312.
    • Karakousis GC, Gimotty PA, Leong SP, Pockaj BA, White RL, O'Donoghue C, Sinnamon AJ, Bartlett EK, Dueck AC, Gould Rothberg BE, Messina JL, Vetto JT, Sondak VK, Schneebaum S, Kashani-Sabet M, Han D, Faries MB, Zager JS. Microsatellitosis in Patients with Melanoma. Ann Surg Oncol. 2019 Jan.26(1):33-41. Pubmedid: 30421045.
    • Ecker BL, Kaur A, Douglass SM, Webster MR, Almeida FV, Marino GE, Sinnamon AJ, Neuwirth MG, Alicea GM, Ndoye A, Fane M, Xu X, Sim MS, Deutsch GB, Faries MB, Karakousis GC, Weeraratna AT. Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis. Cancer Discov. 2019 Jan.9(1):82-95. Pubmedid: 30279172. Pmcid: PMC6328344.
    • Hanna AN, Sinnamon AJ, Roses RE, Kelz RR, Elder DE, Xu X, Pockaj BA, Zager JS, Fraker DL, Karakousis GC. Relationship between age and likelihood of lymph node metastases in patients with intermediate thickness melanoma (1.01-4.00 mm): A National Cancer Database study. J Am Acad Dermatol. 2019 Feb.80(2):433-440. Pubmedid: 30165160.
    • Sinnamon AJ, Tong JKC, Bailey EA, Brown C, Colbert L, Murray S, Jackson BM, Roses RE. Prospective implementation of a standardized screening protocol for deep venous thrombosis in abdominal surgical oncology patients. J Surg Oncol. 2018 Sep.118(3):568-573. Pubmedid: 30114315.
    • Sinnamon AJ, Song Y, Sharon CE, Yang YX, Elder DE, Zhang PJ, Xu X, Roses RE, Kelz RR, Fraker DL, Karakousis GC. Prediction of Residual Nodal Disease at Completion Dissection Following Positive Sentinel Lymph Node Biopsy for Melanoma. Ann Surg Oncol. 2018 Nov.25(12):3469-3475. Pubmedid: 30043316.
    • Sharon CE, Sinnamon AJ, Ming ME, Chu EY, Fraker DL, Karakousis GC. Association of Marital Status With T Stage at Presentation and Management of Early-Stage Melanoma. JAMA Dermatol. 2018 May.154(5):574-580. Pubmedid: 29710174. Pmcid: PMC6128501.
    • Sinnamon AJ, Neuwirth MG, Gimotty PA, Gangadhar TC, Amaravadi RK, Schuchter LM, Karakousis GC. Association of First-in-Class Immune Checkpoint Inhibition and Targeted Therapy With Survival in Patients With Stage IV Melanoma. JAMA Oncol. 2018 Jan.4(1):126-128. Pubmedid: 29145547. Pmcid: PMC5833649.
    • Sinnamon AJ, Neuwirth MG, Vining CC, Sharoky CE, Yang YX, Kelz RR, Fraker DL, Roses RE, Karakousis GC. Prophylactic Cholecystectomy at Time of Surgery for Small Bowel Neuroendocrine Tumor Does Not Increase Postoperative Morbidity. Ann Surg Oncol. 2018 Jan.25(1):239-245. Pubmedid: 29067602.
    • Neuwirth MG, Bierema C, Sinnamon AJ, Fraker DL, Kelz RR, Roses RE, Karakousis GC. Trends in major upper abdominal surgery for cancer in octogenarians: Has there been a change in patient selection?. Cancer. 2018 Jan.124(1):125-135. Pubmedid: 28881379.
    • Concors SJ, Sinnamon AJ, Folkert IW, Mahmoud NN, Fraker DL, Paulson EC, Roses RE. Predictors of Metastases in Rectal Neuroendocrine Tumors: Results of a National Cohort Study. Dis Colon Rectum. 2018 Dec.61(12):1372-1379. Pubmedid: 30312223.
    • Sinnamon AJ, Gimotty PA, Karakousis GC. Interpreting the Association of First-in-Class Immune Checkpoint Inhibition and Targeted Therapy With Survival in Patients With Stage IV Melanoma-Reply. JAMA Oncol. 2018 Aug.4(8):1136-1137. Pubmedid: 29902301.
    • Sinnamon AJ, Sharon CE, Song Y, Neuwirth MG, Elder DE, Xu X, Chu EY, Ming ME, Fraker DL, Gimotty PA, Karakousis GC. The prognostic significance of tumor-infiltrating lymphocytes for primary melanoma varies by sex. J Am Acad Dermatol. 2018 Aug.79(2):245-251. Pubmedid: 29518458.
    • Vining CC, Sinnamon AJ, Ecker BL, Kelz RR, Fraker DL, Roses RE, Karakousis GC. Adjuvant chemotherapy in resectable synovial sarcoma. J Surg Oncol. 2017 Sep.116(4):550-558. Pubmedid: 28580620.
    • Sinnamon AJ, Neuwirth MG, Yalamanchi P, Gimotty P, Elder DE, Xu X, Kelz RR, Roses RE, Chu EY, Ming ME, Fraker DL, Karakousis GC. Association Between Patient Age and Lymph Node Positivity in Thin Melanoma. JAMA Dermatol. 2017 Sep.153(9):866-873. Pubmedid: 28724122. Pmcid: PMC5710422.
    • Sharoky CE, Bailey EA, Sellers MM, Kaufman EJ, Sinnamon AJ, Wirtalla CJ, Holena DN, Kelz RR. Outcomes of hospitalized patients undergoing emergency general surgery remote from admission. Surgery. 2017 Sep.162(3):612-619. Pubmedid: 28689604.
    • Sharoky CE, Collier KT, Wirtalla CJ, Sinnamon AJ, Neuwirth MG, Kuo LE, Roses RE, Fraker DL, Karakousis GC, Kelz RR. Hospitalization in the Year Preceding Major Oncologic Surgery Increases Risk for Adverse Postoperative Events. Ann Surg Oncol. 2017 Nov.24(12):3477-3485. Pubmedid: 28808930.
    • Ecker BL, Peters MG, McMillan MT, Sinnamon AJ, Zhang PJ, Kelz RR, Roses RE, Drebin JA, Fraker DL, Karakousis GC. Implications of Lymph Node Evaluation in the Management of Resectable Soft Tissue Sarcoma. Ann Surg Oncol. 2017 Feb.24(2):425-433. Pubmedid: 27785659.
    • Neuwirth MG, Song Y, Sinnamon AJ, Fraker DL, Zager JS, Karakousis GC. Isolated Limb Perfusion and Infusion for Extremity Soft Tissue Sarcoma: A Contemporary Systematic Review and Meta-Analysis. Ann Surg Oncol. 2017 Dec.24(13):3803-3810. Pubmedid: 29022281.
    • Sinnamon AJ, Neuwirth MG, Bartlett EK, Zaheer S, Etherington MS, Xu X, Elder DE, Czerniecki BJ, Fraker DL, Karakousis GC. Predictors of false negative sentinel lymph node biopsy in trunk and extremity melanoma. J Surg Oncol. 2017 Dec.116(7):848-855. Pubmedid: 28650537.
    • Sinnamon AJ, Neuwirth MG, McMillan MT, Ecker BL, Bartlett EK, Zhang PJ, Kelz RR, Fraker DL, Roses RE, Karakousis GC. A prognostic model for resectable soft tissue and cutaneous angiosarcoma. J Surg Oncol. 2016 Oct.114(5):557-563. Pubmedid: 27378102.
    • Ecker BL, Peters MG, McMillan MT, Sinnamon AJ, Zhang PJ, Fraker DL, Levin WP, Roses RE, Karakousis GC. Preoperative radiotherapy in the management of retroperitoneal liposarcoma. Br J Surg. 2016 Dec.103(13):1839-1846. Pubmedid: 27682864.
    • Ma P, Ou K, Sinnamon AJ, Jiang H, Siderovski DP, Brass LF. Modulating platelet reactivity through control of RGS18 availability. Blood. 2015 Dec.126(24):2611-2620. Pubmedid: 26407691. Pmcid: PMC4671108.
    • Ma P, Foote DC, Sinnamon AJ, Brass LF. Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1). PLoS One. 2015.10(3):e0119496. Pubmedid: 25785436. Pmcid: PMC4364895.
    • Sinnamon AJ, Sonnenberg EM, Bartlett EK, Meise CK, Wang GJ, Kelz RR. The influence of socioeconomic factors on gender disparities in lower extremity bypass. J Surg Res. 2014 May.188(2):537-544. Pubmedid: 24576778.
    • Bartlett EK, Gimotty PA, Sinnamon AJ, Wachtel H, Roses RE, Schuchter L, Xu X, Elder DE, Ming M, Elenitsas R, Guerry D, Kelz RR, Czerniecki BJ, Fraker DL, Karakousis GC. Clark level risk stratifies patients with mitogenic thin melanomas for sentinel lymph node biopsy. Ann Surg Oncol. 2014 Feb.21(2):643-649. Pubmedid: 24121883. Pmcid: PMC4006195.
    • Ma P, Cierniewska A, Signarvic R, Cieslak M, Kong H, Sinnamon AJ, Neubig RR, Newman DK, Stalker TJ, Brass LF. A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. Blood. 2012 Feb.119(8):1935-1945. Pubmedid: 22210881. Pmcid: PMC3293648.
    • Venters BJ, Wachi S, Mavrich TN, Andersen BE, Jena P, Sinnamon AJ, Jain P, Rolleri NS, Jiang C, Hemeryck-Walsh C, Pugh BF. A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol Cell. 2011 Feb.41(4):480-492. Pubmedid: 21329885. Pmcid: PMC3057419.
  • Patient Comments

    Overall Satisfaction


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