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Doug  Letson

Doug Letson, MD

MMG President

Specialty: Orthopaedic Surgery

Program: Sarcoma

Language(s): English

  • Overview

    Cancer Focus:
    Osteosarcoma, Sarcoma

    Dr. G. Douglas Letson is executive vice president of clinical affairs and physician-in-chief at Moffitt Cancer Center, as well as prior chair of the Sarcoma Department. In addition, he is a professor of surgery, radiology and orthopaedics at the University of South Florida. As an orthopaedic oncology surgeon, Dr. Letson’s research and clinical interests include: novel therapeutic agents to treat sarcoma; limb salvage for bone and soft tissue tumors; as well as segmental prosthesis, new hinge designs and soft tissue attachment for metallic prosthesis. Dr. Letson has a keen interest in new techniques and design of instrumentation for minimal invasive reconstructive surgery. He collaborated with Stanmore Corporation in England to develop a non-invasive leg lengthening implant, and he is the only physician in the United States to implant and lengthen the limbs of several children successfully. A graduate of Louisiana State University School of Medicine, Dr. Letson completed his residency in orthopedics at LSU affiliated hospitals, where he was chief resident at LSU Children’s Hospital. He pursued advanced training through a musculoskeletal oncology fellowship at Massachusetts General Hospital-Harvard Medical School and was awarded Clinical Oncology Fellow of the American Cancer Society. Prior to joining Moffitt in 2000, he was with the Watson Clinic in Lakeland, FL, and with the Florida Orthopaedic Institute in Tampa. Dr. Letson is a frequent guest speaker at local and international physician conferences and has received numerous awards, including American Orthopaedic Academy Honor Society, Professor of the Year at Orlando Regional Healthcare, Teacher of the Year for the USF Radiology Department and Best Doctors in America.

    Education & Training


    • Massachusetts General Hospital – Harvard Medical School - Musculoskeletal Oncology


    • Louisiana State University Medical School Affiliated Hospitals - Orthopaedics

    Medical School:

    • Louisiana State University - MD
  • Publications

    • West W, Moore A, Gerhardt C, Webb P, Binitie O, Lazarides A, Letson D, Joyce D. Dual plating in the metastatic distal humerus: Benefits may outweigh the risks. J Orthop. 2024 May.51:103-108. Pubmedid: 38361983. Pmcid: PMC10864758.
    • Belzarena AC, Binitie O, Letson GD, Joyce DM. Unplanned Sarcoma Excisions: Understanding How They Happen. J Am Acad Orthop Surg Glob Res Rev. 2024 Jan.8(1). Pubmedid: 38252542. Pmcid: PMC10805420.
    • Caracciolo JT, Ali S, Chang CY, Degnan AJ, Flemming DJ, Henderson ER, Kransdorf MJ, Letson GD, Madewell JE, Murphey MD. Bone Tumor Risk Stratification and Management System: A Consensus Guideline from the ACR Bone Reporting and Data System Committee. J Am Coll Radiol. 2023 Oct.20(10):1044-1058. Pubmedid: 37855758.
    • Crimì A, Joyce DM, Binitie O, Ruggieri P, Letson GD. The history of resection prosthesis. Int Orthop. 2023 Mar.47(3):873-883. Pubmedid: 36651984.
    • Huynh THN, Kuruvilla DR, Nester MD, Zervoudakis G, Letson GD, Joyce DM, Binitie OT, Lazarides AL. Limb Amputations in Cancer: Modern Perspectives, Outcomes, and Alternatives. Curr Oncol Rep. 2023 Dec.25(12):1457-1465. Pubmedid: 37999825.
    • Yang G, Yuan Z, Ahmed K, Welsh EA, Fulp WJ, Gonzalez RJ, Mullinax JE, Letson D, Bui M, Harrison LB, Scott JG, Torres-Roca JF, Naghavi AO. Genomic identification of sarcoma radiosensitivity and the clinical implications for radiation dose personalization. Transl Oncol. 2021 Oct.14(10):101165. Pubmedid: 34246048. Pmcid: PMC8274330.
    • Alexander JH, Binitie OT, Letson GD, Joyce DM. Osteosarcoma: An Evolving Understanding of a Complex Disease. J Am Acad Orthop Surg. 2021 Oct.29(20):e993-e1004. Pubmedid: 34623342.
    • Mason NT, Burkett JM, Nelson RS, Pow-Sang JM, Gatenby RA, Kubal T, Peabody JW, Letson GD, McLeod HL, Zhang J. Budget Impact of Adaptive Abiraterone Therapy for Castration-Resistant Prostate Cancer. Am Health Drug Benefits. 2021 Mar.14(1):15-20. Pubmedid: 33841621. Pmcid: PMC8025923.
    • Broman KK, Joyce D, Binitie O, Letson GD, Gonzalez RJ, Choi J, Mullinax JE. Intraoperative Localization Using an Implanted Radar Reflector Facilitates Resection of Non-Palpable Trunk and Extremity Sarcoma. Ann Surg Oncol. 2021 Jun.28(6):3366-3374. Pubmedid: 33073344.
    • Belzarena AC, Binitie O, Letson D, Joyce DM. Intramedullary rod failure in metastatic breast cancer: Do triple negative cancer patients have more revision surgery?. J Bone Oncol. 2021 Jun.28:100358. Pubmedid: 33898214. Pmcid: PMC8056433.
    • Liu W, Chan CM, Gong L, Bui MM, Han G, Letson GD, Yang Y, Niu X. Malignancy in giant cell tumor of bone in the extremities. J Bone Oncol. 2021 Feb.26:100334. Pubmedid: 33251099. Pmcid: PMC7680773.
    • Leavey PJ, Laack NN, Krailo MD, Buxton A, Randall RL, DuBois SG, Reed DR, Grier HE, Hawkins DS, Pawel B, Nadel H, Womer RB, Letson GD, Bernstein M, Brown K, Maciej A, Chuba P, Ahmed AA, Indelicato DJ, Wang D, Marina N, Gorlick R, Janeway KA, Mascarenhas L. Phase III Trial Adding Vincristine-Topotecan-Cyclophosphamide to the Initial Treatment of Patients With Nonmetastatic Ewing Sarcoma: A Children's Oncology Group Report. J Clin Oncol. 2021 Dec.39(36):4029-4038. Pubmedid: 34652968. Pmcid: PMC8677904.
    • Henderson ER, Keeney BJ, Husson EG, Bernthal NM, Ji T, Pala E, Funovics PT, Groundland JS, Lozano-Calderon S, Puchner S, Zoller SD, Ruggieri P, Windhager R, Guo W, Hornicek FJ, Letson GD, Temple HT. Nonmechanical Revision Indications Portend Repeat Limb-Salvage Failure Following Total Femoral Replacement. J Bone Joint Surg Am. 2020 Sep.102(17):1511-1520. Pubmedid: 32453111.
    • Piakong P, Kiatisevi P, Yau R, Trovarelli G, Lam YL, Joyce D, Ruggieri P, Temple HT, Letson D, Binitie O. What Is the 10-year Survivorship of Cemented Distal Femoral Endoprostheses for Tumor Reconstructions and What Radiographic Features Are Associated with Survival?. Clin Orthop Relat Res. 2020 Nov.478(11):2573-2581. Pubmedid: 32469487. Pmcid: PMC7594923.
    • Spiess PE, Greene J, Keenan RJ, Paculdo D, Letson GD, Peabody JW. Meeting the challenge of the 2019 novel coronavirus disease in patients with cancer. Cancer. 2020 Jul.126(14):3174-3175. Pubmedid: 32324273. Pmcid: PMC7264676.
    • Johnson D, Ouenes O, Letson D, de Belen E, Kubal T, Czarnecki C, Weems L, Box B, Paculdo D, Peabody J. A Direct Comparison of the Clinical Practice Patterns of Advanced Practice Providers and Doctors. Am J Med. 2019 Nov.132(11):e778-e785. Pubmedid: 31145882.
    • Boddu S, Walko CM, Bienasz S, Bui MM, Henderson-Jackson E, Naghavi AO, Mullinax JE, Joyce DM, Binitie O, Letson GD, Gonzalez RJ, Reed DR, Druta M, Brohl AS. Clinical Utility of Genomic Profiling in the Treatment of Advanced Sarcomas: A Single-Center Experience. JCO Precis Oncol. 2018 Nov.2:1-8. Pubmedid: 35135155.
    • Palumbo BT, Henderson E, Rizer J, Letson DG, Cheong D. Computer navigation and distal femoral reconstruction in the oncologic patient. J Orthop. 2017 Jun.14(2):257-263. Pubmedid: 28377642. Pmcid: PMC5369330.
    • Naghavi AO, Gonzalez RJ, Scott JG, Mullinax JE, Abuodeh YA, Kim Y, Binitie O, Ahmed KA, Bui MM, Saini AS, Zager JS, Biagioli MC, Letson D, Harrison LB, Fernandez DC. Implications of staged reconstruction and adjuvant brachytherapy in the treatment of recurrent soft tissue sarcoma. Brachytherapy. 2017 Jul.15(4):495-503. Pubmedid: 27180128. Pmcid: PMC7771533.
    • Durfee RA, Sabo SA, Letson GD, Binitie O, Cheong D. Percutaneous Acetabuloplasty for Metastatic Lesions to the Pelvis. Orthopedics. 2017 Jan.40(1):e170-e175. Pubmedid: 27783835.
    • Reed DR, Oshrine B, Pratt C, Fridgen O, Elstner C, Wilson L, Soliman H, Lee MC, McLeod HL, Shah B, Donovan KA, Pabbathi S, Turney M, Binitie O, Healy C, Nieder M, Shaw PH, Galligan A, Letson GD, Stern M, Quinn GP, Davies S. Sink or Collaborate: How the Immersive Model Has Helped Address Typical Adolescent and Young Adult Barriers at a Single Institution and Kept the Adolescent and Young Adult Program Afloat. J Adolesc Young Adult Oncol. 2017 Dec.6(4):503-511. Pubmedid: 28777007. Pmcid: PMC5725631.
    • Henderson ER, Keeney BJ, Pala E, Funovics PT, Eward WC, Groundland JS, Ehrlichman LK, Puchner SS, Brigman BE, Ready JE, Temple HT, Ruggieri P, Windhager R, Letson GD, Hornicek FJ. The stability of the hip after the use of a proximal femoral endoprosthesis for oncological indications: analysis of variables relating to the patient and the surgical technique. Bone Joint J. 2017 Apr.99-B(4):531-537. Pubmedid: 28385944.
    • Kubal T, Letson DG, Chiappori AA, Springett GM, Shimkhada R, Tamondong Lachica D, Peabody JW. Longitudinal cohort study to determine effectiveness of a novel simulated case and feedback system to improve clinical pathway adherence in breast, lung and GI cancers. BMJ Open. 2016 Sep.6(9):e012312. Pubmedid: 27625063. Pmcid: PMC5030551.
    • Caracciolo JT, Letson GD. Radiologic Approach to Bone and Soft Tissue Sarcomas. Surg Clin N Am. 2016 Oct.96(5):963-976. Pubmedid: 27542636.
    • Daw NC, Laack NN, McIlvaine EJ, Krailo M, Womer RB, Granowetter L, Grier HE, Marina NM, Bernstein ML, Gebhardt MC, Marcus KJ, Advani SM, Healey JH, Letson GD, Gorlick RG, Randall RL. Local Control Modality and Outcome for Ewing Sarcoma of the Femur: A Report From the Children's Oncology Group. Ann Surg Oncol. 2016 Oct.23(11):3541-3547. Pubmedid: 27216741. Pmcid: PMC5136500.
    • Bertrand TE, Cruz A, Binitie O, Cheong D, Letson GD. Do Surgical Margins Affect Local Recurrence and Survival in Extremity, Nonmetastatic, High-grade Osteosarcoma?. Clin Orthop Relat Res. 2016 Mar.474(3):677-683. Pubmedid: 26013153. Pmcid: PMC4746163.
    • Caracciolo JT, Temple HT, Letson GD, Kransdorf MJ. A Modified Lodwick-Madewell Grading System for the Evaluation of Lytic Bone Lesions. Ajr Am J Roentgenol. 2016 Jul.207(1):150-156. Pubmedid: 27070373.
    • Doepker MP, Hanna KH, Thompson ZJ, Binitie OT, Letson DG, Gonzalez RJ. Recurrence and survival analysis of resected soft tissue sarcomas of pelvic retroperitoneal structures. J Surg Oncol. 2016 Jan.113(1):103-107. Pubmedid: 26744131.
    • Raj S, Bui MM, Springett G, Conley A, Lavilla-Alonso S, Zhao X, Chen D, Haysek R, Gonzalez R, Letson GD, Finkelstein SE, Chiappori AA, Gabrilovitch DI, Antonia SJ. Long-Term Clinical Responses of Neoadjuvant Dendritic Cell Infusions and Radiation in Soft Tissue Sarcoma. Sarcoma. 2016 Feb.2015:614736. Pubmedid: 26880867. Pmcid: PMC4735941.
    • Groundland JS, Ambler SB, Houskamp LD, Orriola JJ, Binitie OT, Letson GD. Surgical and Functional Outcomes After Limb-Preservation Surgery for Tumor in Pediatric Patients: A Systematic Review. JBJS Rev. 2016 Feb.4(2). Pubmedid: 27490132.
    • Niu X, Xu H, Inwards CY, Li Y, Ding Y, Letson GD, Bui MM. Primary Bone Tumors: Epidemiologic Comparison of 9200 Patients Treated at Beijing Ji Shui Tan Hospital, Beijing, China, With 10 165 Patients at Mayo Clinic, Rochester, Minnesota. Arch Pathol Lab Med. 2015 Sep.139(9):1149-1155. Pubmedid: 25978765.
    • DeVito N, Henderson E, Han G, Reed D, Bui MM, Lavey R, Robinson L, Zager JS, Gonzalez RJ, Sondak VK, Letson GD, Conley A. Clinical Characteristics and Outcomes for Solitary Fibrous Tumor (SFT): A Single Center Experience. PLoS One. 2015 Oct.10(10):e0140362. Pubmedid: 26469269. Pmcid: PMC4607370.
    • Kubal T, Peabody JW, Friedman E, Levine R, Pursell S, Letson DG. Using Vignettes to Measure and Encourage Adherence to Clinical Pathways in a Quality-Based Oncology Network: An Early Report on the Moffitt Oncology Network Initiative. Manag Care. 2015 Oct.24(10):56-64. Pubmedid: 26665718.
    • Henderson ER, Gao J, Groundland J, Binitie O, Letson GD. Expandable Total Humeral Replacement in a Child with Osteosarcoma. Case Rep Orthop. 2015 Jun.2015:690159. Pubmedid: 26090254. Pmcid: PMC4452195.
    • Xu H, Nugent D, Monforte HL, Binitie OT, Ding Y, Letson GD, Cheong D, Niu X. Chondroblastoma of bone in the extremities: a multicenter retrospective study. J Bone Joint Surg Am. 2015 Jun.97(11):925-931. Pubmedid: 26041854.
    • Dossett LA, Toloza EM, Fontaine J, Robinson LA, Reed D, Druta M, Letson DG, Zager JS, Gonzalez RJ. Outcomes and clinical predictors of improved survival in a patients undergoing pulmonary metastasectomy for sarcoma. J Surg Oncol. 2015 Jul.112(1):103-106. Pubmedid: 26179670.
    • Bielack SS, Smeland S, Whelan JS, Marina N, Jovic G, Hook JM, Krailo MD, Gebhardt M, Pápai Z, Meyer J, Nadel H, Randall RL, Deffenbaugh C, Nagarajan R, Brennan B, Letson GD, Teot LA, Goorin A, Baumhoer D, Kager L, Werner M, Lau CC, Sundby Hall K, Gelderblom H, Meyers P, Gorlick R, Windhager R, Helmke K, Eriksson M, Hoogerbrugge PM, Schomberg P, Tunn PU, Kühne T, Jürgens H, van den Berg H, Böhling T, Picton S, Renard M, Reichardt P, Gerss J, Butterfass-Bahloul T, Morris C, Hogendoorn PC, Seddon B, Calaminus G, Michelagnoli M, Dhooge C, Sydes MR, Bernstein M. Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Respons. J Clin Oncol. 2015 Jul.33(20):2279-2287. Pubmedid: 26033801. Pmcid: PMC4486345.
    • Whelan JS, Bielack SS, Marina N, Smeland S, Jovic G, Hook JM, Krailo M, Anninga J, Butterfass-Bahloul T, Böhling T, Calaminus G, Capra M, Deffenbaugh C, Dhooge C, Eriksson M, Flanagan AM, Gelderblom H, Goorin A, Gorlick R, Gosheger G, Grimer RJ, Hall KS, Helmke K, Hogendoorn PC, Jundt G, Kager L, Kuehne T, Lau CC, Letson GD, Meyer J, Meyers PA, Morris C, Mottl H, Nadel H, Nagarajan R, Randall RL, Schomberg P, Schwarz R, Teot LA, Sydes MR, Bernstein M. EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment. Ann Oncol. 2015 Feb.26(2):407-414. Pubmedid: 25421877. Pmcid: PMC4304379.
    • Xu H, Niu X, Li Y, Binitie OT, Letson GD, Cheong D. What are the results using the modified trapdoor procedure to treat chondroblastoma of the femoral head?. Clin Orthop Relat Res. 2014 Nov.472(11):3462-3467. Pubmedid: 25115583. Pmcid: PMC4182374.
    • Henderson ER, O'Connor MI, Ruggieri P, Windhager R, Funovics PT, Gibbons CL, Guo W, Hornicek FJ, Temple HT, Letson GD. Classification of failure of limb salvage after reconstructive surgery for bone tumours : a modified system Including biological and expandable reconstructions. Bone Joint J. 2014 Nov.96-B(11):1436-1440. Pubmedid: 25371453.
    • Finkelstein SE, Trotti A, Letson G, Russell M, Delaney TF, Alektiar KM, Michalski JM, Wang D, Kadir T, Stevens CW. Deformable Imaging Capability for the Radiation Therapy Oncology Group (RTOG) Consensus Atlas of Musculoskeletal Anatomy (CAMAS) for Soft Tissue Sarcoma of the Lower Extremities. Pract Radiat Oncol. 2014 Mar.3(2 Suppl 1):S7. Pubmedid: 24674567.
    • Haddox CL, Han G, Anijar L, Binitie O, Letson GD, Bui MM, Reed DR. Osteosarcoma in pediatric patients and young adults: a single institution retrospective review of presentation, therapy, and outcome. Sarcoma. 2014 Jun.2014:402509. Pubmedid: 24976784. Pmcid: PMC4021746.
    • Wu H, Zhang L, Shao H, Sokol L, Sotomayor E, Letson D, Bui MM. Prognostic significance of soft tissue extension, international prognostic index, and multifocality in primary bone lymphoma: a single institutional experience. Brit J Haematol. 2014 Jul.166(1):60-68. Pubmedid: 24673481.
    • Wu H, Bui MM, Leston DG, Shao H, Sokol L, Sotomayor EM, Zhang L. Clinical characteristics and prognostic factors of bone lymphomas: focus on the clinical significance of multifocal bone involvement by primary bone large B-cell lymphomas. BMC Cancer. 2014 Dec.14:900. Pubmedid: 25465716. Pmcid: PMC4265495.
    • Kreahling JM, Foroutan P, Reed D, Martinez G, Razabdouski T, Bui MM, Raghavan M, Letson D, Gillies RJ, Altiok S. Wee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomas. PLoS One. 2013 Sep.8(3):e57523. Pubmedid: 23520471. Pmcid: PMC3592874.
    • Nugent D, Cheong D, Monforte H, Ayala AG, Letson GD, Keen J. Periosteal Mesenchymal Chondrosarcoma in the Distal Part of the Tibia of a Four-Year-Old Boy: A Case Report. JBJS Case Connect. 2013 Oct.3(4):e117. Pubmedid: 29252517.
    • Deneve JL, Messina JL, Bui MM, Marzban SS, Letson GD, Cheong D, Gonzalez RJ, Sondak VK, Zager JS. Cutaneous leiomyosarcoma: treatment and outcomes with a standardized margin of resection. Cancer Control. 2013 Oct.20(4):307-312. Pubmedid: 24077407. Pmcid: PMC4504421.
    • Perez MC, Padhya TA, Messina JL, Jackson RS, Gonzalez RJ, Bui MM, Letson GD, Cruse CW, Lavey RS, Cheong D, Forster MR, Fulp WJ, Sondak VK, Zager JS. Cutaneous angiosarcoma: a single-institution experience. Ann Surg Oncol. 2013 Oct.20(11):3391-3397. Pubmedid: 23835652. Pmcid: PMC4509495.
    • Cubitt CL, Menth J, Dawson J, Martinez GV, Foroutan P, Morse DL, Bui MM, Letson GD, Sullivan DM, Reed DR. Rapid screening of novel agents for combination therapy in sarcomas. Sarcoma. 2013 Nov.2013:365723. Pubmedid: 24282374. Pmcid: PMC3824404.
    • Binitie O, Tejiram S, Conway S, Cheong D, Temple HT, Letson GD. Adult soft tissue sarcoma local recurrence after adjuvant treatment without resection of core needle biopsy tract. Clin Orthop Relat Res. 2013 Mar.471(3):891-898. Pubmedid: 22968531. Pmcid: PMC3563812.
    • Vohra NA, Turaga KK, Gonzalez RJ, Conley A, Reed D, Bui MM, Cheong D, Letson DG, Zager JS. The use of isolated limb infusion in limb threatening extremity sarcomas. Int J Hyperthermia. 2013 Jun.29(1):1-7. Pubmedid: 23205633. Pmcid: PMC4509503.
    • Mavrogenis AF, Lenze U, Rechl H, Letson GD, Ruggieri P. Recent developments in the surgical treatment of bone tumors and their impact on quality of life. Sarcoma. 2013 Aug.2013:826432. Pubmedid: 23935391. Pmcid: PMC3725717.
    • Alexander GE, Gutierrez S, Nayak A, Palumbo BT, Cheong D, Letson GD, Santoni BG. Biomechanical model of a high risk impending pathologic fracture of the femur: lesion creation based on clinically implemented scoring systems. Clin Biomech (Bristol, Avon). 2013 Apr.28(4):408-414. Pubmedid: 23597777.
    • Henderson ER, Pepper AM, Marulanda G, Binitie OT, Cheong D, Letson GD. Outcome of lower-limb preservation with an expandable endoprosthesis after bone tumor resection in children. J Bone Joint Surg Am. 2012 Mar.94(6):537-547. Pubmedid: 22438003.
    • Ebb D, Meyers P, Grier H, Bernstein M, Gorlick R, Lipshultz SE, Krailo M, Devidas M, Barkauskas DA, Siegal GP, Ferguson WS, Letson GD, Marcus K, Goorin A, Beardsley P, Marina N. Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group. J Clin Oncol. 2012 Jul.30(20):2545-2551. Pubmedid: 22665540. Pmcid: PMC3397787.
    • Isakoff MS, Barkauskas DA, Ebb D, Morris C, Letson GD. Poor survival for osteosarcoma of the pelvis: a report from the Children's Oncology Group. Clin Orthop Relat Res. 2012 Jul.470(7):2007-2013. Pubmedid: 22354612. Pmcid: PMC3369072.
    • Kreahling JM, Gemmer JY, Reed D, Letson D, Bui M, Altiok S. MK1775, a selective Wee1 inhibitor, shows single-agent antitumor activity against sarcoma cells. Mol Cancer Ther. 2012 Jan.11(1):174-182. Pubmedid: 22084170. Pmcid: PMC4545500.
    • Parsons CM, Pimiento JM, Cheong D, Marzban SS, Gonzalez RJ, Johnson D, Letson GD, Zager JS. The role of radical amputations for extremity tumors: a single institution experience and review of the literature. J Surg Oncol. 2012 Feb.105(2):149-155. Pubmedid: 21837679. Pmcid: PMC4504014.
    • Finkelstein SE, Iclozan C, Bui MM, Cotter MJ, Ramakrishnan R, Ahmed J, Noyes DR, Cheong D, Gonzalez RJ, Heysek RV, Berman C, Lenox BC, Janssen W, Zager JS, Sondak VK, Letson GD, Antonia SJ, Gabrilovich DI. Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients. Int J Radiat Oncol Biol Phys. 2012 Feb.82(2):924-932. Pubmedid: 21398051. Pmcid: PMC4241354.
    • Henderson ER, Pepper AM, Letson GD. What are estimated reimbursements for lower extremity prostheses capable of surgical and nonsurgical lengthening?. Clin Orthop Relat Res. 2012 Apr.470(4):1194-1203. Pubmedid: 22125242. Pmcid: PMC3293973.
    • Palumbo BT, Henderson E, Letson D, Cheong D. Biology, classification, and management of recurrent myxofibrosarcoma 21 years after resection. Am J Orthop (Belle Mead NJ). 2011 Nov.40(11):579-582. Pubmedid: 22263212.
    • Henderson ER, Groundland JS, Pala E, Dennis JA, Wooten R, Cheong D, Windhager R, Kotz RI, Mercuri M, Funovics PT, Hornicek FJ, Temple HT, Ruggieri P, Letson GD. Failure mode classification for tumor endoprostheses: retrospective review of five institutions and a literature review. J Bone Joint Surg Am. 2011 Mar.93(5):418-429. Pubmedid: 21368074.
    • Palumbo BT, Henderson ER, Groundland JS, Cheong D, Pala E, Letson GD, Ruggieri P. Advances in segmental endoprosthetic reconstruction for extremity tumors: a review of contemporary designs and techniques. Cancer Control. 2011 Jul.18(3):160-170. Pubmedid: 21666578.
    • Turaga KK, Beasley GM, Kane JM, Delman KA, Grobmyer SR, Gonzalez RJ, Letson GD, Cheong D, Tyler DS, Zager JS. Limb preservation with isolated limb infusion for locally advanced nonmelanoma cutaneous and soft-tissue malignant neoplasms. Arch Surg. 2011 Jul.146(7):870-875. Pubmedid: 21768436. Pmcid: PMC4515974.
    • Cheong D, Letson GD. Computer-assisted navigation and musculoskeletal sarcoma surgery. Cancer Control. 2011 Jul.18(3):171-176. Pubmedid: 21666579.
    • Henderson ER, Marulanda GA, Cheong D, Temple HT, Letson GD. Hip abductor moment arm--a mathematical analysis for proximal femoral replacement. J Orthop Surg Res. 2011 Jan.6:6. Pubmedid: 21266066. Pmcid: PMC3247065.
    • Henderson ER, Jennings JM, Marulanda GA, Groundland JS, Cheong D, Letson GD. Enhancing soft tissue ingrowth in proximal femoral arthroplasty with aortograft sleeve a novel technique and early results. J Arthroplasty. 2011 Jan.26(1):161-163. Pubmedid: 20801613.
    • Mavrogenis AF, Lesensky J, Romagnoli C, Alberghini M, Letson GD, Ruggieri P. Atypical Lipomatous Tumors/Well-differentiated Liposarcomas: Clinical Outcome of 67 Patients. Orthopedics. 2011 Dec.34(12):e893-e898. Pubmedid: 22146207.
    • Kraybill WG, Harris J, Spiro IJ, Ettinger DS, DeLaney TF, Blum RH, Lucas DR, Harmon DC, Letson GD, Eisenberg B. Long-term results of a phase 2 study of neoadjuvant chemotherapy and radiotherapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514. Cancer. 2010 Oct.116(19):4613-4621. Pubmedid: 20572040. Pmcid: PMC3780573.
    • Henderson ER, Pepper AM, Marulanda GA, Millard JD, Letson GD. What is the emotional acceptance after limb salvage with an expandable prosthesis?. Clin Orthop Relat Res. 2010 Nov.468(11):2933-2938. Pubmedid: 20632139. Pmcid: PMC2947674.
    • Marulanda GA, Henderson E, Cheong D, Letson GD. Proximal and total humerus reconstruction with the use of an aortograft mesh. Clin Orthop Relat Res. 2010 Nov.468(11):2896-2903. Pubmedid: 20568029. Pmcid: PMC2947671.
    • Demetri GD, Antonia S, Benjamin RS, Bui MM, Casper ES, Conrad EU, DeLaney TF, Ganjoo KN, Heslin MJ, Hutchinson RJ, Kane JM, Letson GD, McGarry SV, O'Donnell RJ, Paz IB, Pfeifer JD, Pollock RE, Randall RL, Riedel RF, Schupak KD, Schwartz HS, Thornton K, von Mehren M, Wayne J. Soft tissue sarcoma. J Natl Compr Canc Ne. 2010 Jun.8(6):630-674. Pubmedid: 20581298.
    • Henderson ER, Jennings JM, Marulanda GA, Palumbo BT, Cheong D, Letson GD. Purse-string capsule repair to reduce proximal femoral arthroplasty dislocation for tumor--a novel technique with results. J Arthroplasty. 2010 Jun.25(4):654-657. Pubmedid: 20097040.
    • Biermann JS, Adkins DR, Benjamin RS, Brigman B, Chow W, Conrad EU, Frassica DA, Frassica FJ, George S, Hande KR, Hornicek FJ, Letson GD, Mayerson J, McGarry SV, McGrath B, Morris CD, O'Donnell RJ, Randall RL, Santana VM, Satcher RL, Siegel HJ, Somaiah N, Yasko AW. Bone cancer. J Natl Compr Canc Ne. 2010 Jun.8(6):688-712. Pubmedid: 20581300.
    • Farma JM, Ammori JB, Zager JS, Marzban SS, Bui MM, Bichakjian CK, Johnson TM, Lowe L, Sabel MS, Wong SL, Letson GD, Messina JL, Cimmino VM, Sondak VK. Dermatofibrosarcoma protuberans: how wide should we resect?. Ann Surg Oncol. 2010 Aug.17(8):2112-2118. Pubmedid: 20354798.
    • Alexander GE, Henderson ER, Rodriguez AR, Bui MM, Cheong D, Letson GD. Extraskeletal myxoid chondrosarcoma: rare presentation in the knee joint space. Orthopedics. 2009 Dec.32(12):919. Pubmedid: 19968226.
    • Potter BK, Chow VE, Adams SC, Letson GD, Temple HT. Endoprosthetic proximal femur replacement: metastatic versus primary tumors. Surg Oncol. 2009 Dec.18(4):343-349. Pubmedid: 18835153.
    • Marulanda G, Mont M, Lucci A, Letson G, Khakpour N. Orthopedic surgery implications of breast cancer. Expert Rev Anticanc. 2008 Jun.8(6):949-956. Pubmedid: 18533804.
    • Marulanda G, Henderson E, Palumbo B, Alexander G, Cheong D, Letson G. Use of extendable prostheses: a limb-salvaging alternative for patients with malignant bone tumors. Expert Rev Med Devic. 2008 Jul.5(4):467-474. Pubmedid: 18573046.
    • Marulanda G, Henderson E, Johnson D, Letson G, Cheong D. Orthopedic surgery options for the treatment of primary osteosarcoma. Cancer Control. 2008 Jan.15(1):13-20. Pubmedid: 18094657.
    • Bui M, Smith P, Agresta S, Cheong D, Letson G. Practical issues of intraoperative frozen section diagnosis of bone and soft tissue lesions. Cancer Control. 2008 Jan.15(1):7-12. Pubmedid: 18094656.
    • Shor AC, Keschman EA, Lee FY, Muro-Cacho C, Letson GD, Trent JC, Pledger WJ, Jove R. Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival. Cancer Res. 2007 Mar.67(6):2800-2808. Pubmedid: 17363602.
    • Demetri G, Baker L, Benjamin R, Casper E, Conrad EU 3rd, D'Amato G, Delaney T, Ettinger D, Heck R J, Heslin M, Hutchinson R, Jacobs C, Kiel K, Kraybill W, Letson G, O'donnell R, Paz I, Pfeifer J, Pollock R, Randall R, Sasson A, Schupak K, Tyler D, Mehren M, Wayne J. Soft tissue sarcoma. J Natl Compr Canc Ne. 2007 Apr.5(4):364-399. Pubmedid: 17442230.
    • Biermann J, Adkins D, Benjamin R, Brigman B, Chow W, Conrad EU 3rd, Frassica D, Frassica F, George S, Healey J, Heck R J, Letson G, Mayerson J, McGarry S, O'donnell R, Patt J, Randall R, Santana V, Satcher R, Schmidt R, Siegel H, Wong M, Yasko A. Bone cancer. J Natl Compr Canc Ne. 2007 Apr.5(4):420-437. Pubmedid: 17442233.
    • Kraybill W, Harris J, Spiro I, Ettinger D, DeLaney T, Blum R, Lucas DR, Harmon D, Letson G, Eisenberg B. Phase II study of neoadjuvant chemotherapy and radiation therapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514. J Clin Oncol. 2006 Feb.24(4):619-625. Pubmedid: 16446334.
    • Demetri GD, Baker LH, Beech D, Benjamin R, Casper ES, Conrad EU, DeLaney TF, Ettinger DS, Heslin MJ, Hutchinson RJ, Kiel K, Kraybill WG, Letson GD, Neff J, O'Donnell RJ, Paz IB, Pollock RE, Randall RL, Schupak KD, Tyler DS, von Mehren M, Wayne J. Soft tissue sarcoma clinical practice guidelines in oncology. J Natl Compr Canc Ne. 2005 Mar.3(2):158-194. Pubmedid: 19817028. Pmcid: PMC5788173.
    • Letson G. Soft tissue sarcoma: status in 2005. Cancer Control. 2005 Jan.12(1):2. Pubmedid: 15668647.
    • Knapp E, Kransdorf M, Letson G. Diagnostic imaging update: soft tissue sarcomas. Cancer Control. 2005 Jan.12(1):22-26. Pubmedid: 15668649.
    • Saba HI, Morelli GA, Azam RR, Klein CJ, Letson GD. Efficacy of NovoSeven during surgery on a haemophiliac with previous history of inhibitors. Haemophilia. 2003 Jan.9(1):131-136. Pubmedid: 12558792.
    • Kim C, Puleo C, Letson G, Reintgen D. Hyperthermic isolated limb perfusion for extremity sarcomas. Cancer Control. 2001 May.8(3):269-273. Pubmedid: 11378653.
    • Strickland L, Letson GD, Muro-Cacho C. Gastrointestinal stromal tumors. Cancer Control. 2001 May.8(3):252-261. Pubmedid: 11378651.
    • Letson G, Muro-Cacho C. Genetic and molecular abnormalities in tumors of the bone and soft tissues. Cancer Control. 2001 May.8(3):239-251. Pubmedid: 11378650.
    • Neel M, Letson G. Modular endoprostheses for children with malignant bone tumors. Cancer Control. 2001 Jul.8(4):344-348. Pubmedid: 11483888.
    • Letson G, Ward W. Appropriate follow-up of orthopaedic oncology patients. Instr Course Lect. 1999.48:603-606. Pubmedid: 10098088.
    • Garcia E, Sandin R, Greene J, Baekey P, Walling A, Letson G, Choy J, Nicosia S, Moscinski L. Infections of the leg which mimic malignancy. Infect Med. 1998.15(8):557-567.
    • Letson GD, McEwen GD, Choy JY. A technique for excision of an osteoid osteoma. Orthopedics. 1997 Mar.20(3):266-268. Pubmedid: 9088020.
    • Letson G, Greenfield G, Heinrich S. Evaluation of the child with a bone or soft-tissue neoplasm. Orthop Clin N Am. 1996 Jul.27(3):431-451. Pubmedid: 8649727.
    • Letson GD, D'Ambrosia RD, Aguilar EA, Wagespack A. Activity relationships of total hip arthroplasty in patients with osteonecrosis and osteoarthritis. Orthopedics. 1996 Aug.19(8):665-668. Pubmedid: 8856776.
    • Letson GD. Diagnosis and Treatment of Soft Tissue Sarcomas. Cancer Control. 1994 Nov.1(6):566-567. Pubmedid: 10887008.
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