Farah Khalil, MD

Cancer Focus:
Lung Cancer, Mesothelioma, Pancoast Tumor, Thymoma

Farah Khalil, MD is a Senior Member in the Department of Anatomic Pathology at Moffitt Cancer Center, Director of the Histology and Immunohistochemistry Laboratory, and Professor of Oncologic Sciences at USF. Clinically, she focuses on Pulmonary Pathology. Dr. Khalil earned her medical degree from Khyber Medical College, University of Peshawar, and completed her residency in anatomic and clinical pathology at the University of Florida, followed by an oncologic surgical pathology fellowship at H. Lee Moffitt Cancer Center.

Education & Training

Fellowship:

• H. Lee Moffitt Cancer Center - Oncologic Surgical Pathology

Residency:

• University of South Florida - Anatomic & Clinical Pathology

Medical School:

• Khyber Medical College, University of Peshawar - MBBS

• Roy J, Putt KS, Coppola D, Leon ME, Khalil FK, Centeno BA, Clark N, Stark VE, Morse DL, Low PS. Addendum: Assessment of cholecystokinin 2 receptor (CCK2R) in neoplastic tissue. Oncotarget. 2025 Mar.16:132. Pubmedid: 40042992. Pmcid: PMC11884436.
• Waqas A, Khan A, Ozturk ZG, Saeed-Vafa D, Chen W, Dhillon J, Bychkov A, Bui MM, Ullah E, Khalil F, Chumbalkar V, Jameel Z, Bittar HT, Singh RS, Parwani AV, Schabath MB, Rasool G. REASONING BEYOND ACCURACY: EXPERT EVALUATION OF LARGE LANGUAGE MODELS IN DIAGNOSTIC PATHOLOGY. medRxiv. 2025 Apr. Pubmedid: 40297448. Pmcid: PMC12036407.
• Tripathi A, Waqas A, Venkatesan K, Ullah E, Khan A, Khalil F, Chen WS, Ozturk ZG, Saeed-Vafa D, Bui MM, Schabath MB, Rasool G. Employing Consensus-Based Reasoning with Locally Deployed LLMs for Enabling Structured Data Extraction from Surgical Pathology Reports. medRxiv. 2025 Apr. Pubmedid: 40343037. Pmcid: PMC12060942.
• Dacic S, Travis WD, Giltnane JM, Kos F, Abel J, Hilz S, Fujimoto J, Sholl L, Ritter J, Khalil F, Liu Y, Taylor-Weiner A, Resnick M, Yu H, Hirsch FR, Bunn PA, Carbone DP, Rusch V, Kwiatkowski DJ, Johnson BE, Lee JM, Hennek SR, Wapinski I, Nicholas A, Johnson A, Schulze K, Kris MG, Wistuba II. Artificial Intelligence-Powered Assessment of Pathologic Response to Neoadjuvant Atezolizumab in Patients With NSCLC: Results From the LCMC3 Study. J Thorac Oncol. 2024 May.19(5):719-731. Pubmedid: 38070597.
• Shahamatdar S, Saeed-Vafa D, Linsley D, Khalil F, Lovinger K, Li L, McLeod HT, Ramachandran S, Serre T. Deceptive learning in histopathology. Histopathology. 2024 Jul.85(1):116-132. Pubmedid: 38556922. Pmcid: PMC11162337.
• Rybolt L, Oehler RL, Khalil FK, Khalil B, Toney JF. A 22-Year-Old With a Left Apical Chest Mass. Clin Infect Dis. 2024 Jan.78(1):199-201. Pubmedid: 38272460.
• Kerr KM, Bubendorf L, Lopez-Rios F, Khalil F, Roy-Chowdhuri S, Joubert P, Hartmann A, Guerini-Rocco E, Yatabe Y, Hofman P, Cooper WA, Dacic S. Optimizing tissue stewardship in non-small cell lung cancer to support molecular characterization and treatment selection: statement from a working group of thoracic pathologists. Histopathology. 2024 Feb.84(3):429-439. Pubmedid: 37957137.
• Baron JM, Widatalla S, Gubens MA, Khalil F. Real-World Biomarker Test Ordering Practices in Non-Small Cell Lung Cancer: Interphysician Variation and Association With Clinical Outcomes. JCO Precis Oncol. 2024 Aug.8:e2400039. Pubmedid: 39208373. Pmcid: PMC11371103.
• Zota V, Siegal GP, Kelly D, Bridge JA, Berglund A, Bui K, Khalil F, R Reed D, Altiok S, Magliocco A, Bui MM. Validation of PRKCB Immunohistochemistry as a Biomarker for the Diagnosis of Ewing Sarcoma. Fetal Pediatr Pathol. 2023 Apr.42(2):241-252. Pubmedid: 36062956.
• Baby S, Khalil F, Tanvetyanon T. Frontline pembrolizumab for the treatment of RET-rearranged non-small cell lung cancer: A case report. Cancer Treat Res Commun. 2021 Jun.28:100423. Pubmedid: 34166867.
• Boyle TA, Khalil FK, Mino-Kenudson M, Sica GL, Moreira AL, Sholl LM, Knight MZ, Zhang L, Saller J, Varella-Garcia M, Berry LD, Chen H, Ellison KE, Rivard CJ, Kugler K, Wistuba II, Fujimoto J, Kwiatkowski DJ, Bunn PA, Kris MG, Haura EB, Hirsch FR. Round Robin Evaluation of MET Protein Expression in Lung Adenocarcinomas Improves Interobserver Concordance. Appl Immunohistochem Mol Morphol. 2020 Oct.28(9):669-677. Pubmedid: 31876606. Pmcid: PMC7242128.
• Mohamed AZ, Khalil FK, Toloza EM, Tanvetyanon T. Metastasectomy for Isolated Right-Sided Thoracic Lymph Node Metastasis From Tubal Carcinoma. Am Surg. 2020 May.86(5):521-523. Pubmedid: 32684038.
• Creelan BC, Ahmad MU, Kaszuba FJ, Khalil FK, Welsh AW, Ozdemirli M, Grant NN, Subramaniam DS. Clinical Activity of Nivolumab for Human Papilloma Virus-Related Juvenile-Onset Recurrent Respiratory Papillomatosis. Oncologist. 2019 Jun.24(6):829-835. Pubmedid: 30842242. Pmcid: PMC6656512.
• Mumtaz H, Khalil F, Tandon A, Toloza E, Fontaine JP. Primary bronchial Ewing sarcoma. Int J Surg Case Rep. 2019 Jul.61:230-233. Pubmedid: 31377551. Pmcid: PMC6698311.
• Saltos A, Khalil F, Smith M, Li J, Schell M, Antonia SJ, Gray JE. Clinical associations of mucin 1 in human lung cancer and precancerous lesions. Oncotarget. 2018 Nov.9(86):35666-35675. Pubmedid: 30479696. Pmcid: PMC6235019.
• Gray JE, Chiappori A, Williams CC, Tanvetyanon T, Haura EB, Creelan BC, Kim J, Boyle TA, Pinder-Schenck M, Khalil F, Altiok S, Devane R, Noyes D, Mediavilla-Varela M, Smilee R, Hopewell EL, Kelley L, Antonia SJ. A phase I/randomized phase II study of GM.CD40L vaccine in combination with CCL21 in patients with advanced lung adenocarcinoma. Cancer Immunol Immun. 2018 Dec.67(12):1853-1862. Pubmedid: 30209589. Pmcid: PMC6244998.
• Prabhakaran S, Rizk VT, Ma Z, Cheng CH, Berglund AE, Coppola D, Khalil F, Mulé JJ, Soliman HH. Evaluation of invasive breast cancer samples using a 12-chemokine gene expression score: correlation with clinical outcomes. Breast Cancer Res. 2017 Jun.19(1):71. Pubmedid: 28629479. Pmcid: PMC5477261.
• Qin D, Zheng Z, Shen S, Smith P, Khalil FK. Necessity of Microdissecting Different Tumor Components in Pulmonary Tumor Pyrosequencing. Biomed Res Int. 2017 Feb.2016:8759267. Pubmedid: 27597976. Pmcid: PMC4997073.
• Cohen AS, Khalil FK, Welsh EA, Schabath MB, Enkemann SA, Davis A, Zhou JM, Boulware DC, Kim J, Haura EB, Morse DL. Cell-surface marker discovery for lung cancer. Oncotarget. 2017 Dec.8(69):113373-113402. Pubmedid: 29371917. Pmcid: PMC5768334.
• Al Diffalha S, Al Aukla N, Hasan S, Dickinson S, Khalil F. NUT Midline Carcinoma: A Rare Malignancy. Cancer Control. 2017 Apr.24(2):202-206. Pubmedid: 28441376.
• Garcia-Henriquez N, Toloza EM, Khalil F, Echavarria MF, Garrett JR, Moodie CC, Kaszuba FJ, Fontaine JP. Extensive plastic bronchitis: etiology of a rare condition. J Thorac Dis. 2016 Sep.8(9):E961-E965. Pubmedid: 27747036. Pmcid: PMC5059329.
• Roy J, Putt KS, Coppola D, Leon ME, Khalil FK, Centeno BA, Clark N, Stark VE, Morse DL, Low PS. Assessment of cholecystokinin 2 receptor (CCK2R) in neoplastic tissue. Oncotarget. 2016 Mar.7(12):14605-14615. Pubmedid: 26910279. Pmcid: PMC4924738.
• Serdiuk A, Khalil F, Cohen JB. Images in Anesthesiology: An Unexpected Embolism during a Craniotomy. Anesthesiology. 2016 Mar.124(3):721. Pubmedid: 26288269.
• Smith MA, Hall R, Fisher K, Haake SM, Khalil F, Schabath MB, Vuaroqueaux V, Fiebig HH, Altiok S, Chen YA, Haura EB. Annotation of human cancers with EGFR signaling-associated protein complexes using proximity ligation assays. Sci Signal. 2015 Jan.8(359):ra4. Pubmedid: 25587191. Pmcid: PMC4440040.
• Khalil FK, Altiok S. Advances in EGFR as a Predictive Marker in Lung Adenocarcinoma. Cancer Control. 2015 Apr.22(2):193-199. Pubmedid: 26068764.
• Soliman H, Khalil F, Antonia S. PD-L1 expression is increased in a subset of basal type breast cancer cells. PLoS One. 2014 Feb.9(2):e88557. Pubmedid: 24551119. Pmcid: PMC3925108.
• Mediavilla-Varela M, Luddy K, Noyes D, Khalil FK, Neuger AM, Soliman H, Antonia S. Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth. Cancer Biol Ther. 2013 Sep.14(9):860-868. Pubmedid: 23917542. Pmcid: PMC3909555.
• Soliman H, Rawal B, Fulp J, Lee JH, Lopez A, Bui MM, Khalil F, Antonia S, Yfantis HG, Lee DH, Dorsey TH, Ambs S. Analysis of indoleamine 2-3 dioxygenase (IDO1) expression in breast cancer tissue by immunohistochemistry. Cancer Immunol Immun. 2013 May.62(5):829-837. Pubmedid: 23344392. Pmcid: PMC4501769.
• McNab P, Quigley B, Mendoza T, Hakam A, Khalil F, Fishman M, Altiok S. The histogenic origin of melanoma arising in respiratory epithelium of a teratomatous germ cell tumor of the mediastinum: an enigma unraveled from an unlikely source. Int J Clin Exp Pathol. 2013 Apr.5(9):982-990. Pubmedid: 23119117. Pmcid: PMC3484497.
• Schlauder SM, Calder KB, Khalil FK, Passmore L, Mathew RA, Morgan MB. Bif-1 and Bax expression in cutaneous Merkel cell carcinoma. J Cutan Pathol. 2009 Jan.36(1):21-25. Pubmedid: 19125733.
• Coppola D, Khalil F, Eschrich SA, Boulware D, Yeatman T, Wang HG. Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma. Cancer. 2008 Nov.113(10):2665-2670. Pubmedid: 18833585. Pmcid: PMC2614910.
• Calder K, Khalil F, Schlauder S, Cualing H, Morgan M. Immunohistochemical expression of survivin in cutaneous sebaceous lesions. Am J Dermatopathxxx. 2008 Dec.30(6):545-548. Pubmedid: 19033926.
• Khalil FK, Keehn CA, Saeed S, Morgan MB. Verrucous psoriasis: a distinctive clinicopathologic variant of psoriasis. Am J Dermatopathxxx. 2005 Jun.27(3):204-207. Pubmedid: 15900122.
• Khalil FK, Sagatys E, Morgan MB. What is it? Unusual interstitial fibrohistiocytic tumor or other. Am J Dermatopathxxx. 2004 Jun.26(3):255-256. Pubmedid: 15166520.
• Khalil FK, Wallis-Crespo MC, Gilbert-Barness E. Pathology teach and tell: eosinophilic granuloma. Fetal Pediatr Pathol. 2004 Jul.23(4):281-284. Pubmedid: 16095040.