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James  Costello

James Costello, MD, PhD

Specialty: Radiology

Program: Diagnostic Imaging and Interventional Radiology

Language(s): English

  • Overview

    Education & Training


    • University of Arizona School of Medicine - Translational Science Body MRI


    • Emory University School of Medicine - Radiology

    Medical School:

    • Emory University School of Medicine - MD
  • Publications

    • Arias-Lorza AM, Costello JR, Hingorani SR, Von Hoff DD, Korn RL, Raghunand N. Magnetic resonance imaging of tumor response to stroma-modifying pegvorhyaluronidase alpha (PEGPH20) therapy in early-phase clinical trials. Sci Rep. 2024 May.14(1):11570. Pubmedid: 38773189. Pmcid: PMC11109088.
    • Hoffe SE, Aguilera TA, Parikh PJ, Ghaly MM, Herman JM, Caster JM, Kim DW, Costello J, Malafa MP, Moser EC, Kennedy EP, Terry K, Kurman M. Stereotactic body radiotherapy plus rucosopasem in locally advanced or borderline resectable pancreatic cancer: GRECO-2 phase II study design. Future Oncol. 2024 Mar.20(8):437-446. Pubmedid: 38264869. Pmcid: PMC10988540.
    • Kierans AS, Costello J, Qayyum A, Taouli B, Venkatesh SK, Yoon JH, Bali MA, Bolan CW, Lee JM, Marks RM, El Homsi M, Miller FH. Imaging cholangiocarcinoma: CT and MRI techniques. Abdom Radiol (NY). 2024 Jun. Pubmedid: 38916614.
    • Jeong D, Morse B, Polk SL, Chen DT, Li J, Hodul P, Centeno BA, Costello J, Jiang K, Machado S, El Naqa I, Farah PT, Huynh T, Raghunand N, Mok S, Dam A, Malafa M, Qayyum A, Fleming JB, Permuth JB. Pancreatic Cyst Size Measurement on Magnetic Resonance Imaging Compared to Pathology. Cancers (Basel). 2024 Jan.16(1). Pubmedid: 38201633. Pmcid: PMC10778543.
    • Ogunleye O, Feuerlein S, Ahmed A, Parsee A, Jeong D, Henning J, Frakes J, Stefanou A, Sanchez J, Hoffe S, Dessureault S, Felder S, Costello J. The role of rectal magnetic resonance imaging in accurate localization and designation of colorectal cancer for optimal management: Case study. Radiol Case Rep. 2024 Aug.19(8):3042-3048. Pubmedid: 38745979. Pmcid: PMC11091459.
    • Turner K, Kim DW, Gonzalez BD, Gore LR, Gurd E, Milano J, Riccardi D, Byrne M, Al-Jumayli M, de Castria TB, Laber DA, Hoffe S, Costello J, Robinson E, Chadha JS, Rajasekhara S, Hume E, Hagen R, Nguyen OT, Nardella N, Parker N, Carson TL, Tabriz AA, Hodul P. Support Through Remote Observation and Nutrition Guidance (STRONG), a digital health intervention to reduce malnutrition among pancreatic cancer patients: A study protocol for a pilot randomized controlled trial. Contemp Clin Trials Commun. 2024 Apr.38:101271. Pubmedid: 38440777. Pmcid: PMC10910065.
    • Naghavi AO, Bryant JM, Kim Y, Weygand J, Redler G, Sim AJ, Miller J, Coucoules K, Michael LT, Gloria WE, Yang G, Rosenberg SA, Ahmed K, Bui MM, Henderson-Jackson EB, Lee A, Lee CD, Gonzalez RJ, Feygelman V, Eschrich SA, Scott JG, Torres-Roca J, Latifi K, Parikh N, Costello J. Habitat escalated adaptive therapy (HEAT): a phase 2 trial utilizing radiomic habitat-directed and genomic-adjusted radiation dose (GARD) optimization for high-grade soft tissue sarcoma. BMC Cancer. 2024 Apr.24(1):437. Pubmedid: 38594603. Pmcid: PMC11003059.
    • Fraum TJ, Ma J, Jhaveri K, Nepal P, Lall C, Costello J, Harisinghani M. The optimized rectal cancer MRI protocol: choosing the right sequences, sequence parameters, and preparatory strategies. Abdom Radiol (NY). 2023 Sep.48(9):2771-2791. Pubmedid: 36899281.
    • Arias-Lorza AM, Costello JR, Hingorani SR, Von Hoff DD, Korn RL, Raghunand N. Tumor Response to Stroma-Modifying Therapy: Magnetic Resonance Imaging Findings in Early-Phase Clinical Trials of Pegvorhyaluronidase alpha (PEGPH20). Res Sq. 2023 Sep. Pubmedid: 37720027. Pmcid: PMC10503830.
    • Weygand J, Armstrong T, Bryant JM, Andreozzi JM, Oraiqat IM, Nichols S, Liveringhouse CL, Latifi K, Yamoah K, Costello JR, Frakes JM, Moros EG, El Naqa IM, Naghavi AO, Rosenberg SA, Redler G. Accurate, repeatable, and geometrically precise diffusion-weighted imaging on a 0.35 T magnetic resonance imaging-guided linear accelerator. Phys Imaging Radiat Oncol. 2023 Oct.28:100505. Pubmedid: 38045642. Pmcid: PMC10692914.
    • Ravi H, Arias-Lorza AM, Costello JR, Han HS, Jeong DK, Klinz SG, Sachdev JC, Korn RL, Raghunand N. Pretherapy Ferumoxytol-enhanced MRI to Predict Response to Liposomal Irinotecan in Metastatic Breast Cancer. Radiol Imaging Cancer. 2023 Mar.5(2):e220022. Pubmedid: 36734848. Pmcid: PMC10077095.
    • Laajala TD, Sreekanth V, Soupir A, Creed J, Calboli FC, Singaravelu K, Orman M, Colin-Leitzinger C, Gerke T, Fridley BL, Tyekucheva S, Costello JC. curatedPCaData: Integration of clinical, genomic, and signature features in a curated and harmonized prostate cancer data resource. bioRxiv. 2023 Jan. Pubmedid: 36711769. Pmcid: PMC9882125.
    • Taniguchi CM, Frakes JM, Aguilera TA, Palta M, Czito B, Bhutani MS, Colbert LE, Abi Jaoude J, Bernard V, Pant S, Tzeng CD, Kim DW, Malafa M, Costello J, Mathew G, Rebueno N, Koay EJ, Das P, Ludmir EB, Katz MHG, Wolff RA, Beddar S, Sawakuchi GO, Moningi S, Slack Tidwell RS, Yuan Y, Thall PF, Beardsley RA, Holmlund J, Herman JM, Hoffe SE. Stereotactic body radiotherapy with or without selective dismutase mimetic in pancreatic adenocarcinoma: an adaptive, randomised, double-blind, placebo-controlled, phase 1b/2 trial. Lancet Oncol. 2023 Dec.24(12):1387-1398. Pubmedid: 38039992.
    • Felder SI, Feuerlein S, Parsee A, Imanirad I, Sanchez J, Dessureault S, Kim R, Hoffe S, Frakes J, Costello J. Endoscopic and MRI response evaluation following neoadjuvant treatment for rectal cancer: a pictorial review with matched MRI, endoscopic, and pathologic examples. Abdom Radiol (NY). 2021 May.46(5):1783-1804. Pubmedid: 33111189.
    • Tomaszewski MR, Dominguez-Viqueira W, Ortiz A, Shi Y, Costello JR, Enderling H, Rosenberg SA, Gillies RJ. Heterogeneity analysis of MRI T2 maps for measurement of early tumor response to radiotherapy. Nmr Biomed. 2021 Mar.34(3):e4454. Pubmedid: 33325086.
    • Jillson LK, Yette GA, Laajala TD, Tilley WD, Costello JC, Cramer SD. Androgen Receptor Signaling in Prostate Cancer Genomic Subtypes. Cancers (Basel). 2021 Jun.13(13). Pubmedid: 34208794. Pmcid: PMC8269091.
    • Kingsley JL, Costello JR, Raghunand N, Rejniak KA. Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations. PLoS Comput Biol. 2021 Jul.17(7):e1009206. Pubmedid: 34310608. Pmcid: PMC8341701.
    • Czeyda-Pommersheim F, Martin DR, Costello JR, Kalb B. Contrast Agents for MR Imaging. Magn Reson Imaging Clin N Am. 2017 Nov.25(4):705-711. Pubmedid: 28964460.
    • Czeyda-Pommersheim F, Kalb B, Costello J, Liau J, Meshksar A, Arif Tiwari H, Martin D. MRI in pelvic inflammatory disease: a pictorial review. Abdom Radiol (NY). 2017 03.42(3):935-950. Pubmedid: 27933478.
    • Petkovska I, Duke E, Martin DR, Irani Z, Geffre CP, Cragun JM, Costello JR, Arif-Tiwari H, Czeyda-Pommersheim F, Udayasankar U, Kalb B. MRI of ovarian torsion: Correlation of imaging features with the presence of perifollicular hemorrhage and ovarian viability. Eur J Radiol. 2016 Nov.85(11):2064-2071. Pubmedid: 27776660.
    • Petkovska I, Martin DR, Covington MF, Urbina S, Duke E, Daye ZJ, Stolz LA, Keim SM, Costello JR, Chundru S, Arif-Tiwari H, Gilbertson-Dahdal D, Gries L, Kalb B. Accuracy of Unenhanced MR Imaging in the Detection of Acute Appendicitis: Single-Institution Clinical Performance Review. Radiology. 2016 May.279(2):451-460. Pubmedid: 26807893.
    • Costello JR, Kalb B, Martin DR. Incidence and Risk Factors for Gadolinium-Based Contrast Agent Immediate Reactions. Top Magn Reson Imaging. 2016 Dec.25(6):257-263. Pubmedid: 27748714.
    • Moinuddin I, Bracamonte E, Thajudeen B, Sussman A, Madhrira M, Costello J. Allergic Interstitial Nephritis Manifesting as a Striated Nephrogram. Case Rep Med. 2015 Dec.2015:250530. Pubmedid: 26664405. Pmcid: PMC4667022.
    • Costello JR, Kalb B, Chundru S, Arif H, Petkovska I, Martin DR. MR imaging of benign and malignant biliary conditions. Magn Reson Imaging Clin N Am. 2014 Aug.22(3):467-488. Pubmedid: 25086940.
    • Chundru S, Kalb B, Arif-Tiwari H, Sharma P, Costello J, Martin DR. MRI of diffuse liver disease: the common and uncommon etiologies. Diagn Interv Radiol. 2013 Nov.19(6):479-487. Pubmedid: 23921268.
    • Costello JR, Mullins ME, Votaw JR, Karolyi DR, Kalb B, Gonzales P, Fornwalt B, Meltzer CC. Establishing a new radiology residency research track. Acad Radiol. 2013 Feb.20(2):243-248. Pubmedid: 23085410.
    • Kalb B, Sharma P, Tigges S, Ray GL, Kitajima HD, Costello JR, Chen Z, Martin DR. MR imaging of pulmonary embolism: diagnostic accuracy of contrast-enhanced 3D MR pulmonary angiography, contrast-enhanced low-flip angle 3D GRE, and nonenhanced free-induction FISP sequences. Radiology. 2012 Apr.263(1):271-278. Pubmedid: 22438448.
    • Arif-Tiwari H, Kalb B, Chundru S, Sharma P, Costello J, Guessner RW, Martin DR. MRI of hepatocellular carcinoma: an update of current practices. Diagn Interv Radiol. 20(3):209-221. Pubmedid: 24808419. Pmcid: PMC4463351.
    • Chundru S, Kalb B, Arif-Tiwari H, Sharma P, Costello J, Martin DR. MRI of diffuse liver disease: characteristics of acute and chronic diseases. Diagn Interv Radiol. 20(3):200-208. Pubmedid: 24808418. Pmcid: PMC4463342.
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