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Les  Folio

Les Folio, DO, MPH

Specialty: Radiology

Program: Diagnostic Imaging and Interventional Radiology

Language(s): English

  • Overview

    Dr. Les Folio is a Senior Member in the Moffitt Cancer Center Department of Diagnostic Imaging and Interventional Radiology. Dr. Folio received a DO from the Philadelphia College of Osteopathic Medicine and an MPH degree from the University of California, Berkeley. He completed a residency in Radiology at the Philadelphia College of Osteopathic Medicine and a residency in Aerospace Medicine and General Preventative Medicine at the U.S. Air Force School of Aerospace Medicine. Dr. Folio joined Moffitt from the National Institutes of Health, where he was a Senior Research Physician and lead computed tomography radiologist. Dr. Folio is passionate about leveraging augmented intelligence (human-driven artificial intelligence) to advance cancer imaging analytics and diagnostics. His research interests include improving precision of automated identification and quantification of metastatic tumor burden to optimize cancer therapeutic regimens.  

    Education & Training

    Board Certification:

    • Radiology -


    • United States School of Aerospace Medicine - Preventive Medicine
    • Osteopathic Medical Center of Philadelphia - Radiology
    • United States Air Force School of Aerospace Medicine - Aerospace Medicine

    Medical School:

    • Philadelphia College of Osteopathic Medicine - DO
  • Publications

    • Vahdati S, Khosravi B, Mahmoudi E, Zhang K, Rouzrokh P, Faghani S, Moassefi M, Tahmasebi A, Andriole KP, Chang P, Farahani K, Flores MG, Folio L, Houshmand S, Giger ML, Gichoya JW, Erickson BJ. A Guideline for Open-Source Tools to Make Medical Imaging Data Ready for Artificial Intelligence Applications: A Society of Imaging Informatics in Medicine (SIIM) Survey. J Imaging Inform Med. 2024 Apr. Pubmedid: 38558368.
    • El Naqa I, Karolak A, Luo Y, Folio L, Tarhini AA, Rollison D, Parodi K. Translation of AI into oncology clinical practice. Oncogene. 2023 Oct.42(42):3089-3097. Pubmedid: 37684407.
    • Malarkey M, Toscano AP, Bagheri MH, Solomon J, Machado LB, LoRusso P, Chen A, Folio LR, Goncalves PH. A pilot study of volumetric and density tumor analysis of ACC patients treated with vorinostat in a phase II clinical trial. Heliyon. 2023 Aug.9(8):e18680. Pubmedid: 37593628. Pmcid: PMC10428039.
    • Ware JM, Folio LR, Pittaluga S, Klion A, Khoury P. Resolution of hypereosinophilic syndrome following resection of a schwannoma. J Allergy Clin Immunol Pract. 2023 Apr.11(4):1320-1322. Pubmedid: 36621605. Pmcid: PMC10085834.
    • Lee C, Yeom YS, Folio L. CT organ dose calculator size adaptive for pediatric and adult patients. Biomed Phys Eng Express. 2022 Oct.8(6). Pubmedid: 36206721.
    • Rajaraman S, Cohen G, Spear L, Folio L, Antani S. DeBoNet: A deep bone suppression model ensemble to improve disease detection in chest radiographs. PLoS One. 2022 Mar.17(3):e0265691. Pubmedid: 35358235. Pmcid: PMC8970404.
    • Yao Y, Du Jiang P, Chao BN, Cagdas D, Kubo S, Balasubramaniyam A, Zhang Y, Shadur B, NaserEddin A, Folio LR, Schwarz B, Bohrnsen E, Zheng L, Lynberg M, Gottlieb S, Leney-Greene MA, Park AY, Tezcan I, Akdogan A, Gocmen R, Onder S, Rosenberg A, Soilleux EJ, Johnson E, Jackson PK, Demeter J, Chauvin SD, Paul F, Selbach M, Bulut H, Clatworthy MR, Tuong ZK, Zhang H, Stewart BJ, Bosio CM, Stepensky P, Clare S, Ganesan S, Pascall JC, Daumke O, Butcher GW, McMichael AJ, Simon AK, Lenardo MJ. GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans. J Exp Med. 2022 Jun.219(6). Pubmedid: 35551368. Pmcid: PMC9111091.
    • Spear LG, Dimperio JA, Wang SS, Do HM, Folio LR. Rethinking Clinical Trial Radiology Workflows and Student Training: Integrated Virtual Student Shadowing Experience, Education, and Evaluation. J Digit Imaging. 2022 Jun.35(3):723-731. Pubmedid: 35194736. Pmcid: PMC8863390.
    • Staziaki PV, Santinha JAA, Coelho MO, Angulo D, Hussain M, Folio LR. Gamification in Radiology Training Module Developed During the Society for Imaging Informatics in Medicine Annual Meeting Hackathon. J Digit Imaging. 2022 Jun.35(3):714-722. Pubmedid: 35166970. Pmcid: PMC9156580.
    • Yang F, Lu PX, Deng M, Wáng YXJ, Rajaraman S, Xue Z, Folio LR, Antani SK, Jaeger S. Annotations of Lung Abnormalities in Shenzhen Chest X-ray Dataset for Computer-Aided Screening of Pulmonary Diseases. Data (Basel). 2022 Jul.7(7). Pubmedid: 36381384. Pmcid: PMC9645800.
    • Rajaraman S, Zamzmi G, Folio LR, Antani S. Detecting Tuberculosis-Consistent Findings in Lateral Chest X-Rays Using an Ensemble of CNNs and Vision Transformers. Front Genet. 2022 Feb.13:864724. Pubmedid: 35281798. Pmcid: PMC8907925.
    • Berkowitz SJ, Kwan D, Cornish TC, Silver EL, Thullner KS, Aisen A, Bui MM, Clark SD, Clunie DA, Eid M, Hartman DJ, Ho K, Leontiev A, Luviano DM, O'Toole PE, Parwani AV, Pereira NS, Rotemberg V, Vining DJ, Gaskin CM, Roth CJ, Folio LR. Interactive Multimedia Reporting Technical Considerations: HIMSS-SIIM Collaborative White Paper. J Digit Imaging. 2022 Aug.35(4):817-833. Pubmedid: 35962150. Pmcid: PMC9485305.
    • Marciano BE, Olivier KN, Folio LR, Zerbe CS, Hsu AP, Freeman AF, Filie AC, Spinner MA, Sanchez LA, Lovell JP, Parta M, Cuellar-Rodriguez JM, Hickstein DD, Holland SM. Pulmonary Manifestations of GATA2 Deficiency. Chest. 2021 Oct.160(4):1350-1359. Pubmedid: 34089740. Pmcid: PMC8546236.
    • Candemir S, Nguyen XV, Folio LR, Prevedello LM. Training Strategies for Radiology Deep Learning Models in Data-limited Scenarios. Radiol Artif Intell. 2021 Nov.3(6):e210014. Pubmedid: 34870217. Pmcid: PMC8637222.
    • Shafiei A, Bagheri M, Farhadi F, Apolo AB, Biassou NM, Folio LR, Jones EC, Summers RM. CT Evaluation of Lymph Nodes That Merge or Split during the Course of a Clinical Trial: Limitations of RECIST 1.1. Radiol Imaging Cancer. 2021 May.3(3):e200090. Pubmedid: 33874734. Pmcid: PMC8189184.
    • Rajaraman S, Zamzmi G, Folio L, Alderson P, Antani S. Chest X-ray Bone Suppression for Improving Classification of Tuberculosis-Consistent Findings. Diagnostics (Basel). 2021 May.11(5). Pubmedid: 34067034. Pmcid: PMC8151767.
    • Rajaraman S, Folio LR, Dimperio J, Alderson PO, Antani SK. Improved Semantic Segmentation of Tuberculosis-Consistent Findings in Chest X-rays Using Augmented Training of Modality-Specific U-Net Models with Weak Localizations. Diagnostics (Basel). 2021 Mar.11(4). Pubmedid: 33808240. Pmcid: PMC8065621.
    • Roth CJ, Clunie DA, Vining DJ, Berkowitz SJ, Berlin A, Bissonnette JP, Clark SD, Cornish TC, Eid M, Gaskin CM, Goel AK, Jacobs GC, Kwan D, Luviano DM, McBee MP, Miller K, Hafiz AM, Obcemea C, Parwani AV, Rotemberg V, Silver EL, Storm ES, Tcheng JE, Thullner KS, Folio LR. Multispecialty Enterprise Imaging Workgroup Consensus on Interactive Multimedia Reporting Current State and Road to the Future: HIMSS-SIIM Collaborative White Paper. J Digit Imaging. 2021 Jun.34(3):495-522. Pubmedid: 34131793. Pmcid: PMC8329131.
    • Catanzano T, Robbins JB, Schwartz FR, Rajiah P, Wang SS, Nandwana S, Soloff EV, Folio LR. Collaborative Writing Projects: Set Yourself up for Success. J Comput Assist Tomo. 2021 Jul.45(4):495-499. Pubmedid: 34270477.
    • Kubala SA, Do HM, Ferré EMN, Schrump DS, Olivier KN, Walls JG, Lionakis MS, Folio LR. Fatal autoimmune pneumonitis requiring bilobectomy and omental flap repair in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Respir Med Case Rep. 2021 Jul.33:101476. Pubmedid: 34401309. Pmcid: PMC8349050.
    • Fuller S, Del Rivero J, Venzon D, Ilanchezhian M, Allen D, Folio L, Ling A, Widemann B, Fontana JR, Glod J. Pulmonary Function in Patients With Multiple Endocrine Neoplasia 2B. J Clin Endocrinol Metab. 2020 Sep.105(9). Pubmedid: 32448901. Pmcid: PMC7365699.
    • Lee C, Liu J, Griffin K, Folio L, Summers RM. Adult patient-specific CT organ dose estimations using automated segmentations and Monte Carlo simulations. Biomed Phys Eng Express. 2020 Jun.6(4):045016. Pubmedid: 33444276.
    • Yeom YS, Villoing D, Greenstein N, Kitahara CM, Folio LR, Kim CH, Lee C. INVESTIGATION OF THE INFLUENCE OF THYROID LOCATION ON IODINE-131 S VALUES. Radiat Prot Dosimetry. 2020 Jul.189(2):163-171. Pubmedid: 32285115. Pmcid: PMC7357322.
    • Catanzano TM, Nandwana SB, Folio LR. Web-based Conferencing: Tips, Tricks, and Scenario-based Best Practices for Clinicians During a Pandemic Crisis. J Comput Assist Tomo. 2020 Jul.44(4):465-471. Pubmedid: 32649430.
    • Do HM, Spear LG, Nikpanah M, Mirmomen SM, Machado LB, Toscano AP, Turkbey B, Bagheri MH, Gulley JL, Folio LR. Augmented Radiologist Workflow Improves Report Value and Saves Time: A Potential Model for Implementation of Artificial Intelligence. Acad Radiol. 2020 Jan.27(1):96-105. Pubmedid: 31818390. Pmcid: PMC8189646.
    • Ravell JC, Matsuda-Lennikov M, Chauvin SD, Zou J, Biancalana M, Deeb SJ, Price S, Su HC, Notarangelo G, Jiang P, Morawski A, Kanellopoulou C, Binder K, Mukherjee R, Anibal JT, Sellers B, Zheng L, He T, George AB, Pittaluga S, Powers A, Kleiner DE, Kapuria D, Ghany M, Hunsberger S, Cohen JI, Uzel G, Bergerson J, Wolfe L, Toro C, Gahl W, Folio LR, Matthews H, Angelus P, Chinn IK, Orange JS, Trujillo-Vargas CM, Franco JL, Orrego-Arango J, Gutiérrez-Hincapié S, Patel NC, Raymond K, Patiroglu T, Unal E, Karakukcu M, Day AG, Mehta P, Masutani E, De Ravin SS, Malech HL, Altan-Bonnet G, Rao VK, Mann M, Lenardo MJ. Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease. J Clin Invest. 2020 Jan.130(1):507-522. Pubmedid: 31714901. Pmcid: PMC6934229.
    • Rajaraman S, Siegelman J, Alderson PO, Folio LS, Folio LR, Antani SK. Iteratively Pruned Deep Learning Ensembles for COVID-19 Detection in Chest X-rays. IEEE Access. 2020 Aug.8:115041-115050. Pubmedid: 32742893. Pmcid: PMC7394290.
    • Apolo AB, Nadal R, Tomita Y, Davarpanah NN, Cordes LM, Steinberg SM, Cao L, Parnes HL, Costello R, Merino MJ, Folio LR, Lindenberg L, Raffeld M, Lin J, Lee MJ, Lee S, Alarcon SV, Yuno A, Dawson NA, Allette K, Roy A, De Silva D, Lee MM, Sissung TM, Figg WD, Agarwal PK, Wright JJ, Ning YM, Gulley JL, Dahut WL, Bottaro DP, Trepel JB. Cabozantinib in patients with platinum-refractory metastatic urothelial carcinoma: an open-label, single-centre, phase 2 trial. Lancet Oncol. 2020 Aug.21(8):1099-1109. Pubmedid: 32645282. Pmcid: PMC8236112.
    • Willemink MJ, Koszek WA, Hardell C, Wu J, Fleischmann D, Harvey H, Folio LR, Summers RM, Rubin DL, Lungren MP. Preparing Medical Imaging Data for Machine Learning. Radiology. 2020 Apr.295(1):4-15. Pubmedid: 32068507. Pmcid: PMC7104701.
    • Rajaraman S, Sornapudi S, Alderson PO, Folio LR, Antani SK. Analyzing inter-reader variability affecting deep ensemble learning for COVID-19 detection in chest radiographs. PLoS One. 2020.15(11):e0242301. Pubmedid: 33180877. Pmcid: PMC7660555.
    • Ferré EMN, Break TJ, Burbelo PD, Allgäuer M, Kleiner DE, Jin D, Xu Z, Folio LR, Mollura DJ, Swamydas M, Gu W, Hunsberger S, Lee CR, Bondici A, Hoffman KW, Lim JK, Dobbs K, Niemela JE, Fleisher TA, Hsu AP, Snow LN, Darnell DN, Ojaimi S, Cooper MA, Bozzola M, Kleiner GI, Martinez JC, Deterding RR, Kuhns DB, Heller T, Winer KK, Rajan A, Holland SM, Notarangelo LD, Fennelly KP, Olivier KN, Lionakis MS. Lymphocyte-driven regional immunopathology in pneumonitis caused by impaired central immune tolerance. Sci Transl Med. 2019 Jun.11(495). Pubmedid: 31167928. Pmcid: PMC6647037.
    • Tirosh A, Journy N, Folio LR, Lee C, Leite C, Yao J, Kovacs W, Linehan WM, Malayeri A, Kebebew E, Berrington de González A. Cumulative Radiation Exposures from CT Screening and Surveillance Strategies for von Hippel-Lindau-associated Solid Pancreatic Tumors. Radiology. 2019 Jan.290(1):116-124. Pubmedid: 30299237. Pmcid: PMC6312431.
    • Lee C, Kuzmin GA, Bae J, Yao J, Mosher E, Folio LR. Automatic Mapping of CT Scan Locations on Computational Human Phantoms for Organ Dose Estimation. J Digit Imaging. 2019 Feb.32(1):175-182. Pubmedid: 30187315. Pmcid: PMC6382640.
    • Krupinski E, Bronkalla M, Folio L, Keller B, Mather R, Seltzer S, Schnall M, Cruea R. Advancing the Diagnostic Cockpit of the Future: An Opportunity to Improve Diagnostic Accuracy and Efficiency. Acad Radiol. 2019 Apr.26(4):579-581. Pubmedid: 30578114.
    • Mandell JC, Wortman JR, Rocha TC, Folio LR, Andriole KP, Khurana B. Computed Tomography Window Blending: Feasibility in Thoracic Trauma. Acad Radiol. 2018 Sep.25(9):1190-1200. Pubmedid: 29428212.
    • Mosher EG, Butman JA, Folio LR, Biassou NM, Lee C. Lens Dose Reduction by Patient Posture Modification During Neck CT. Ajr Am J Roentgenol. 2018 May.210(5):1111-1117. Pubmedid: 29547058. Pmcid: PMC8666130.
    • Folio LR, Machado LB, Dwyer AJ. Multimedia-enhanced Radiology Reports: Concept, Components, and Challenges. Radiographics. 2018 Mar.38(2):462-482. Pubmedid: 29528822. Pmcid: PMC5881644.
    • Xue Z, Long R, Jaeger S, Folio L, George Thoma R, Antani AS. Extraction of Aortic Knuckle Contour in Chest Radiographs Using Deep Learning. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul.2018:5890-5893. Pubmedid: 30441676.
    • Sanchez GAM, Reinhardt A, Ramsey S, Wittkowski H, Hashkes PJ, Berkun Y, Schalm S, Murias S, Dare JA, Brown D, Stone DL, Gao L, Klausmeier T, Foell D, de Jesus AA, Chapelle DC, Kim H, Dill S, Colbert RA, Failla L, Kost B, O'Brien M, Reynolds JC, Folio LR, Calvo KR, Paul SM, Weir N, Brofferio A, Soldatos A, Biancotto A, Cowen EW, Digiovanna JJ, Gadina M, Lipton AJ, Hadigan C, Holland SM, Fontana J, Alawad AS, Brown RJ, Rother KI, Heller T, Brooks KM, Kumar P, Brooks SR, Waldman M, Singh HK, Nickeleit V, Silk M, Prakash A, Janes JM, Ozen S, Wakim PG, Brogan PA, Macias WL, Goldbach-Mansky R. JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies. J Clin Invest. 2018 Jul.128(7):3041-3052. Pubmedid: 29649002. Pmcid: PMC6026004.
    • Jaeger S, Juarez-Espinosa OH, Candemir S, Poostchi M, Yang F, Kim L, Ding M, Folio LR, Antani S, Gabrielian A, Hurt D, Rosenthal A, Thoma G. Detecting drug-resistant tuberculosis in chest radiographs. Int J Comput Assist Radiol Surg. 2018 Dec.13(12):1915-1925. Pubmedid: 30284153. Pmcid: PMC6223762.
    • Rayn KN, Ritchie C, Folio LR, Stamatakis L, Verghese MM, Agarwal PK. Bilateral Ureteroenteric Strictures: A Case of the "Reverse 7". Urology. 2018 Aug.118:e3-e4. Pubmedid: 29729367. Pmcid: PMC7983164.
    • Buty M, Xu Z, Wu A, Gao M, Nelson C, Papadakis GZ, Teomete U, Celik H, Turkbey B, Choyke P, Mollura DJ, Bagci U, Folio LR. Quantitative Image Quality Comparison of Reduced- and Standard-Dose Dual-Energy Multiphase Chest, Abdomen, and Pelvis CT. Tomography. 2017 Jun.3(2):114-122. Pubmedid: 28856247. Pmcid: PMC5573232.
    • Goyal N, Apolo AB, Berman ED, Bagheri MH, Levine JE, Glod JW, Kaplan RN, Machado LB, Folio LR. ENABLE (Exportable Notation and Bookmark List Engine): an Interface to Manage Tumor Measurement Data from PACS to Cancer Databases. J Digit Imaging. 2017 Jun.30(3):275-286. Pubmedid: 28074302. Pmcid: PMC5422230.
    • Mandell JC, Khurana B, Folio LR, Hyun H, Smith SE, Dunne RM, Andriole KP. Clinical Applications of a CT Window Blending Algorithm: RADIO (Relative Attenuation-Dependent Image Overlay). J Digit Imaging. 2017 Jun.30(3):358-368. Pubmedid: 28097498. Pmcid: PMC5422232.
    • Ozen A, Comrie WA, Ardy RC, Domínguez Conde C, Dalgic B, Beser ÖF, Morawski AR, Karakoc-Aydiner E, Tutar E, Baris S, Ozcay F, Serwas NK, Zhang Y, Matthews HF, Pittaluga S, Folio LR, Unlusoy Aksu A, McElwee JJ, Krolo A, Kiykim A, Baris Z, Gulsan M, Ogulur I, Snapper SB, Houwen RHJ, Leavis HL, Ertem D, Kain R, Sari S, Erkan T, Su HC, Boztug K, Lenardo MJ. CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis. N Engl J Med. 2017 Jul.377(1):52-61. Pubmedid: 28657829. Pmcid: PMC6690356.
    • Bagheri MH, Ahlman MA, Lindenberg L, Turkbey B, Lin J, Cahid Civelek A, Malayeri AA, Agarwal PK, Choyke PL, Folio LR, Apolo AB. Advances in medical imaging for the diagnosis and management of common genitourinary cancers. Urol Oncol. 2017 Jul.35(7):473-491. Pubmedid: 28506596. Pmcid: PMC5931389.
    • Symons R, Cork TE, Sahbaee P, Fuld MK, Kappler S, Folio LR, Bluemke DA, Pourmorteza A. Low-dose lung cancer screening with photon-counting CT: a feasibility study. Phys Med Biol. 2017 Jan.62(1):202-213. Pubmedid: 27991453. Pmcid: PMC5237389.
    • Machado LB, Apolo AB, Steinberg SM, Folio LR. Radiology Reports With Hyperlinks Improve Target Lesion Selection and Measurement Concordance in Cancer Trials. Ajr Am J Roentgenol. 2017 Feb.208(2):W31-W37. Pubmedid: 28112557. Pmcid: PMC6762032.
    • Symons R, Pourmorteza A, Sandfort V, Ahlman MA, Cropper T, Mallek M, Kappler S, Ulzheimer S, Mahesh M, Jones EC, Malayeri AA, Folio LR, Bluemke DA. Feasibility of Dose-reduced Chest CT with Photon-counting Detectors: Initial Results in Humans. Radiology. 2017 Dec.285(3):980-989. Pubmedid: 28753389. Pmcid: PMC5708286.
    • Kovacs WC, Yao J, Bluemke DA, Folio LR. Opportunities to Reduce CT Radiation Exposure, Experience Over 5 Years at the NIH Clinical Center. Radiat Prot Dosimetry. 2017 Aug.175(4):482-492. Pubmedid: 28096313. Pmcid: PMC5927337.
    • Fenerty KE, Patronas NJ, Heery CR, Gulley JL, Folio LR. Resources Required for Semi-Automatic Volumetric Measurements in Metastatic Chordoma: Is Potentially Improved Tumor Burden Assessment Worth the Time Burden?. J Digit Imaging. 2016 Jun.29(3):357-364. Pubmedid: 26596767. Pmcid: PMC4879033.
    • Candemir S, Jaeger S, Antani S, Bagci U, Folio LR, Xu Z, Thoma G. Atlas-based rib-bone detection in chest X-rays. Comput Med Imag Grap. 2016 Jul.51:32-39. Pubmedid: 27156048. Pmcid: PMC4923658.
    • Karargyris A, Siegelman J, Tzortzis D, Jaeger S, Candemir S, Xue Z, Santosh KC, Vajda S, Antani S, Folio L, Thoma GR. Combination of texture and shape features to detect pulmonary abnormalities in digital chest X-rays. Int J Comput Assist Radiol Surg. 2016 Jan.11(1):99-106. Pubmedid: 26092662.
    • Romanyukha A, Folio L, Lamart S, Simon SL, Lee C. BODY SIZE-SPECIFIC EFFECTIVE DOSE CONVERSION COEFFICIENTS FOR CT SCANS. Radiat Prot Dosimetry. 2016 Dec.172(4):428-437. Pubmedid: 26755767. Pmcid: PMC5204364.
    • Lau CY, Mihalek AD, Wang J, Dodd LE, Perkins K, Price S, Webster S, Pittaluga S, Folio LR, Rao VK, Olivier KN. Pulmonary Manifestations of the Autoimmune Lymphoproliferative Syndrome. A Retrospective Study of a Unique Patient Cohort. Ann Am Thorac Soc. 2016 Aug.13(8):1279-1288. Pubmedid: 27268092. Pmcid: PMC5021079.
    • Fenerty KE, Folio LR, Patronas NJ, Marté JL, Gulley JL, Heery CR. Predicting clinical outcomes in chordoma patients receiving immunotherapy: a comparison between volumetric segmentation and RECIST. BMC Cancer. 2016 Aug.16(1):672. Pubmedid: 27553491. Pmcid: PMC4995658.
    • Weisenthal SJ, Folio L, Kovacs W, Seff A, Derderian V, Summers RM, Yao J. Open-Source Radiation Exposure Extraction Engine (RE3) with Patient-Specific Outlier Detection. J Digit Imaging. 2016 Aug.29(4):406-419. Pubmedid: 26644157. Pmcid: PMC4942384.
    • Pourmorteza A, Symons R, Sandfort V, Mallek M, Fuld MK, Henderson G, Jones EC, Malayeri AA, Folio LR, Bluemke DA. Abdominal Imaging with Contrast-enhanced Photon-counting CT: First Human Experience. Radiology. 2016 Apr.279(1):239-245. Pubmedid: 26840654. Pmcid: PMC4820083.
    • Folio LR, Turkbey EB, Steinberg SM, Apolo AB. Viable tumor volume: Volume of interest within segmented metastatic lesions, a pilot study of proposed computed tomography response criteria for urothelial cancer. Eur J Radiol. 2015 Sep.84(9):1708-1714. Pubmedid: 26149529. Pmcid: PMC4545379.
    • Folio LR, Nelson CJ, Benjamin M, Ran A, Engelhard G, Bluemke DA. Quantitative Radiology Reporting in Oncology: Survey of Oncologists and Radiologists. Ajr Am J Roentgenol. 2015 Sep.205(3):W233-W243. Pubmedid: 26295661. Pmcid: PMC5697144.
    • Folio LR, Craig SH, Wright GA, Battaglia MJ. Loose Body in Elbow of a Baseball Player: Arthroscopic/Radiologic Correlation. Radiol Case Rep. 2015 Nov.1(2):62-65. Pubmedid: 27298684. Pmcid: PMC4891554.
    • Heery CR, Ibrahim NK, Arlen PM, Mohebtash M, Murray JL, Koenig K, Madan RA, McMahon S, Marté JL, Steinberg SM, Donahue RN, Grenga I, Jochems C, Farsaci B, Folio LR, Schlom J, Gulley JL. Docetaxel Alone or in Combination With a Therapeutic Cancer Vaccine (PANVAC) in Patients With Metastatic Breast Cancer: A Randomized Clinical Trial. JAMA Oncol. 2015 Nov.1(8):1087-1095. Pubmedid: 26291768. Pmcid: PMC6622177.
    • Mollura DJ, Palmore TN, Folio LR, Bluemke DA. Radiology preparedness in ebola virus disease: guidelines and challenges for disinfection of medical imaging equipment for the protection of staff and patients. Radiology. 2015 May.275(2):538-544. Pubmedid: 25654616. Pmcid: PMC4456180.
    • Mansoor A, Bagci U, Foster B, Xu Z, Papadakis GZ, Folio LR, Udupa JK, Mollura DJ. Segmentation and Image Analysis of Abnormal Lungs at CT: Current Approaches, Challenges, and Future Trends. Radiographics. 2015 Jul.35(4):1056-1076. Pubmedid: 26172351. Pmcid: PMC4521615.
    • Lee C, Kim KP, Bolch WE, Moroz BE, Folio L. NCICT: a computational solution to estimate organ doses for pediatric and adult patients undergoing CT scans. J Radiol Prot. 2015 Dec.35(4):891-909. Pubmedid: 26609995.
    • Kuehn HS, Ouyang W, Lo B, Deenick EK, Niemela JE, Avery DT, Schickel JN, Tran DQ, Stoddard J, Zhang Y, Frucht DM, Dumitriu B, Scheinberg P, Folio LR, Frein CA, Price S, Koh C, Heller T, Seroogy CM, Huttenlocher A, Rao VK, Su HC, Kleiner D, Notarangelo LD, Rampertaap Y, Olivier KN, McElwee J, Hughes J, Pittaluga S, Oliveira JB, Meffre E, Fleisher TA, Holland SM, Lenardo MJ, Tangye SG, Uzel G. Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4. Science. 2014 Sep.345(6204):1623-1627. Pubmedid: 25213377. Pmcid: PMC4371526.
    • Price S, Shaw PA, Seitz A, Joshi G, Davis J, Niemela JE, Perkins K, Hornung RL, Folio L, Rosenberg PS, Puck JM, Hsu AP, Lo B, Pittaluga S, Jaffe ES, Fleisher TA, Rao VK, Lenardo MJ. Natural history of autoimmune lymphoproliferative syndrome associated with FAS gene mutations. Blood. 2014 Mar.123(13):1989-1999. Pubmedid: 24398331. Pmcid: PMC3968385.
    • Lucas CL, Kuehn HS, Zhao F, Niemela JE, Deenick EK, Palendira U, Avery DT, Moens L, Cannons JL, Biancalana M, Stoddard J, Ouyang W, Frucht DM, Rao VK, Atkinson TP, Agharahimi A, Hussey AA, Folio LR, Olivier KN, Fleisher TA, Pittaluga S, Holland SM, Cohen JI, Oliveira JB, Tangye SG, Schwartzberg PL, Lenardo MJ, Uzel G. Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency. Nat Immunol. 2014 Jan.15(1):88-97. Pubmedid: 24165795. Pmcid: PMC4209962.
    • Olivier KN, Shaw PA, Glaser TS, Bhattacharyya D, Fleshner M, Brewer CC, Zalewski CK, Folio LR, Siegelman JR, Shallom S, Park IK, Sampaio EP, Zelazny AM, Holland SM, Prevots DR. Inhaled amikacin for treatment of refractory pulmonary nontuberculous mycobacterial disease. Ann Am Thorac Soc. 2014 Jan.11(1):30-35. Pubmedid: 24460437. Pmcid: PMC3972984.
    • Jaeger S, Karargyris A, Candemir S, Folio L, Siegelman J, Callaghan F, Zhiyun Xue, Palaniappan K, Singh RK, Antani S, Thoma G, Yi-Xiang Wang, Pu-Xuan Lu, McDonald CJ. Automatic tuberculosis screening using chest radiographs. Ieee T Med Imaging. 2014 Feb.33(2):233-245. Pubmedid: 24108713.
    • Folio LR, Sandouk A, Huang J, Solomon JM, Apolo AB. Consistency and efficiency of CT analysis of metastatic disease: semiautomated lesion management application within a PACS. Ajr Am J Roentgenol. 2013 Sep.201(3):618-625. Pubmedid: 23971455. Pmcid: PMC6771287.
    • Folio LR, Choi MM, Solomon JM, Schaub NP. Automated registration, segmentation, and measurement of metastatic melanoma tumors in serial CT scans. Acad Radiol. 2013 May.20(5):604-613. Pubmedid: 23477826.
    • Folio L, Solomon J, Biassou N, Fischer T, Dworzak J, Raymont V, Sinaii N, Wassermann EM, Grafman J. Semi-automated trajectory analysis of deep ballistic penetrating brain injury. Mil Med. 2013 Mar.178(3):338-345. Pubmedid: 23707123. Pmcid: PMC4936399.
    • Jaeger S, Karargyris A, Candemir S, Siegelman J, Folio L, Antani S, Thoma G. Automatic screening for tuberculosis in chest radiographs: a survey. Quant Imaging Med Surg. 2013 Apr.3(2):89-99. Pubmedid: 23630656. Pmcid: PMC3636475.
    • Sugui JA, Peterson SW, Clark LP, Nardone G, Folio L, Riedlinger G, Zerbe CS, Shea Y, Henderson CM, Zelazny AM, Holland SM, Kwon-Chung KJ. Aspergillus tanneri sp. nov., a new pathogen that causes invasive disease refractory to antifungal therapy. J Clin Microbiol. 2012 Oct.50(10):3309-3317. Pubmedid: 22855513. Pmcid: PMC3457449.
    • Huang J, Bluemke DA, Zhang X, Summers RM, Folio LR, Yao J. A cross-platform and distributive database system for cumulative tumor measurement. Annu Int Conf IEEE Eng Med Biol Soc. 2012 Nov.2012:1266-1269. Pubmedid: 23366129. Pmcid: PMC4161952.
    • Folio L, Spivey M, Chaney JF. UpRight: a radiographic marker that displays upright angle on portable chest and abdominal radiographs. Radiol Technol. 2012 Nov.84(2):199-205. Pubmedid: 23125388.
    • O'Connell ML, Birkenkamp KE, Kleiner DE, Folio LR, Holland SM, Olivier KN. Lung manifestations in an autopsy-based series of pulmonary or disseminated nontuberculous mycobacterial disease. Chest. 2012 May.141(5):1203-1209. Pubmedid: 22194586. Pmcid: PMC3342780.
    • Fischer TV, Folio LR, Backus CE, Bunger R. Case report highlighting how wound path identification on CT can help identify organ damage in abdominal blast injuries. Mil Med. 2012 Jan.177(1):101-107. Pubmedid: 22338990.
    • Abrames E, Folio L. CT severity spectrum of penetrating eye injuries from blasts. Mil Med. 2012 Feb.177(2):169-173. Pubmedid: 22360062.
    • Peterson PG, Pak SK, Nguyen B, Jacobs G, Folio L. Extreme compression for extreme conditions: pilot study to identify optimal compression of CT images using MPEG-4 video compression. J Digit Imaging. 2012 Dec.25(6):764-770. Pubmedid: 22722754. Pmcid: PMC3491159.
    • Folio L, Fischer T, Shogan PJ, Frew M, Bunger R, Provenzale JM. Cartesian positioning system for localization of blast and ballistic fragments: a phantom-based pilot study. Mil Med. 2011 Nov.176(11):1300-1305. Pubmedid: 22165660.
    • Graham RF, Hoskins JD, Cortijo MP, Barbee GA, Folio LR, Lutz CC. A casualty tracking system modeled after air traffic control methodology employed in a combat support hospital in Iraq. Mil Med. 2011 Mar.176(3):244-245. Pubmedid: 21456347.
    • Folio LR, Fischer TV, Shogan PJ, Frew MI, Kang PS, Bunger R, Provenzale JM. CT-based ballistic wound path identification and trajectory analysis in anatomic ballistic phantoms. Radiology. 2011 Mar.258(3):923-929. Pubmedid: 21224425.
    • Shogan PJ, Folio L. Situs inversus totalis. Mil Med. 2011 Jul.176(7):840-843. Pubmedid: 22128729.
    • Folio LR, Fischer T, Shogan P, Frew M, Dwyer A, Provenzale JM. Blast and ballistic trajectories in combat casualties: a preliminary analysis using a cartesian positioning system with MDCT. Ajr Am J Roentgenol. 2011 Aug.197(2):W233-W240. Pubmedid: 21785047.
    • Reed A, Shogan P, Folio L. Radiology corner: Thoracic empyema versus lung abscess. Mil Med. 2010 Sep.175(9):701-702. Pubmedid: 20882937.
    • Johnson R, Folio L. Radiology corner. Solitary pulmonary nodule. Mil Med. 2010 May.175(5):v-vi. Pubmedid: 20486514.
    • Jesinger RA, Ballard EA, Allton DR, Lane JW, Folio L. Bronchiectatic air bronchograms in pulmonary tuberculosis: a case report and literature review. Mil Med. 2010 May.175(5):370-374. Pubmedid: 20486512.
    • Vietor R, Lattin E, Folio L. Radiology corner. Case 45. Noncardiogenic pulmonary edema as a result of urosepsis. Mil Med. 2010 Mar.175(3):iii-iiv. Pubmedid: 20358714.
    • Walker C, Folio L. Radiology corner. Answer to last month's radiology case (#43) and image: Mycobacterium xenopi found incidentally on MRI of the cervical spine. Mil Med. 2010 Jan.175(1):xvii-xviii. Pubmedid: 20108848.
    • Reed A, Dent M, Lewis S, Shogan P, Folio L. Radiology corner. Answer to last month's radiology case and image: hydropneumothorax. Mil Med. 2010 Aug.175(8):625-626. Pubmedid: 20731271.
    • Andrews CM, Andrews KE, Boodoo R, Folio L. Radiology corner. Venous fragment embolism to the pulmonary artery. Mil Med. 2009 Sep.174(9):iv-iv. Pubmedid: 19780380.
    • Rosen A, Zhang Y, Zhan W, Kasprisin A, Martinson S, Cheng J, Weiner M, Yesavage JA, Folio L, Ashford JW. Radiology corner. Case 41. Arcuate fasciculus damage seen on DTI in a blast-exposed soldier with mild traumatic brain injury (mTBI) with associated conduction aphasia. Mil Med. 2009 Nov.174(11):v-vi. Pubmedid: 19960837.
    • Cassleman J, Zakaroff M, Folio L. Radiology corner. Atelectasis secondary to GSW to airway. Mil Med. 2009 May.174(5):vii-viii. Pubmedid: 20731293.
    • Sanghi A, Muncy T, Greenwald S, Monson M, Folio L. Radiology corner. Answer to last month's radiology case (#33). Gymnast wrist. Mil Med. 2009 Mar.174(3):v-vi. Pubmedid: 19354105.
    • Galer M, Magid D, Folio L. Radiology corner. Answer to last month's radiology case and image: gun shot wound to the chest of a military working dog. Mil Med. 2009 Jun.174(6):ix-ix. Pubmedid: 19585787.
    • Hoskins JD, Graham RF, Robinson DR, Lutz CC, Folio LR. Mass casualty tracking with air traffic control methodologies. J Am Coll Surg. 2009 Jun.208(6):1001-1008. Pubmedid: 19476883.
    • Riojas RA, Folio L. Answer to last month's radiology case and image: Bilateral patellar tendon rupture. Mil Med. 2009 Jul.174(7):iii-iiv. Pubmedid: 19685852.
    • Searcey B, Jackson A, Folio L. Answer to last month's radiology case and image: Facial blast injury resulting in sand aspiration. Mil Med. 2009 Jan.174(1):xxiii-xxxiv. Pubmedid: 19216306.
    • Tillman BG, Folio LR. Radiology corner. Answer to last month's radiology case (#32) and images: tuberous sclerosis with epilepsy. Mil Med. 2009 Feb.174(2):xi-xii. Pubmedid: 19317208.
    • Folio L, Robinson D. Radiology corner. Answer to last month's radiology case and image: apical hemothorax from gunshot wound producihg a pleural cap. Mil Med. 2009 Dec.174(12):xxiv-xxxv. Pubmedid: 20055076.
    • Folio RL, Harcke HT, Luzi SA. Aircraft mishap investigation with radiology-assisted autopsy: helicopter crash with control injury. Aviat Space Environ Med. 2009 Apr.80(4):400-404. Pubmedid: 19378913.
    • Federico M, Cunningham B, Paredes A, Lee D, Folio L. Radiology corner. Case 34: Aspergilloma. Mil Med. 2009 Apr.174(4):xv-xvi. Pubmedid: 19485118.
    • Willson TJ, Folio L. Severe epistaxis from an intracranial vascular bleed from grenade injury. Mil Med. 2008 Sep.173(9):934-935. Pubmedid: 18816938.
    • Shogan P, Muncy T, McCarthy K, Folio L. Radiology corner. Answer to last month's radiology case (28): Pneumocystis jiroveci pneumonia. Mil Med. 2008 Oct.173(10):vii-viii. Pubmedid: 19160630.
    • Meagher S, Galifianakis A, Jannotta D, Krapiva P, Folio L. Radiology corner. Answer to last month's radiology case (#29): diffuse axonal injury with negative CT and positive MRI findings. Mil Med. 2008 Nov.173(11):xx-xxi. Pubmedid: 19055195.
    • Abrames EL, Chen SR, Jones W, Folio L. Radiology corner. Traumatic carotid pseudoaneurysm post gun shot wound to the head / neck. Mil Med. 2008 May.173(5):xv-xvi. Pubmedid: 18543577.
    • Peterson G, Ronsivalle J, Folio L. Case #21: Superior Vena Cava (SVC) syndrome. Mil Med. 2008 Mar.173(3):xv-xvi. Pubmedid: 18419041.
    • McKim D, Folio L. Radiology corner. Answer to last month's radiology case and image: Case 24: healing tibial fatigue stress fracture. Mil Med. 2008 Jun.173(6):x-xi. Pubmedid: 18595429.
    • Slotto J, Folio L. Radiology corner. Answer to last month's radiology case (# 25) and image: cystic fibrosis chest X-ray findings: a teaching analog. Mil Med. 2008 Jul.173(7):follow 713. Pubmedid: 18700611.
    • Bigelow D, Folio L. Radiology corner. Angiomyolipoma. Mil Med. 2008 Jan.173(1):xiii-xxiv. Pubmedid: 18251343.
    • Warnock A, Gibson MS, Folio LR. Radiology corner. Answer to last month's radiology case and image: chondroblastoma with secondary aneurysmal bone cyst. Mil Med. 2008 Feb.173(2):xiii-xxiv. Pubmedid: 18333502.
    • Jackson AM, Searcey BK, Smirniotopoulos JG, Folio L. Keyhole fracture of the skull. Mil Med. 2008 Dec.173(12):xix-xxx. Pubmedid: 19149347.
    • Backus C, Folio L. Radiology corner. Answer to last month's radiology case (#26) and image: Lung laceration with loculated blood, active bleeding, contusion and hemothorax. Mil Med. 2008 Aug.173(8):xv-xvi. Pubmedid: 18751605.
    • Penska K, Folio L, Bunger R. Medical applications of digital image morphing. J Digit Imaging. 2007 Sep.20(3):279-283. Pubmedid: 17273920. Pmcid: PMC3043901.
    • Folio LR, Arkin K, Butler WP. Frostbite in a mountain climber treated with hyperbaric oxygen: case report. Mil Med. 2007 May.172(5):560-563. Pubmedid: 17521112.
    • Sanders TG, Lichtenberger JP, Folio L. Answer to last month's radiology case and image: osteoid osteoma. Mil Med. 2007 May.172(5):viii-viix. Pubmedid: 17521114.
    • Ly JQ, Beall DP, Sanders TG, Folio L. Radiology corner. Answer to last month's radiology case and image (case #10): echinococcosis of the liver. Mil Med. 2007 Mar.172(3):vi-vii. Pubmedid: 17436784.
    • Sanders TG, Folio LR. The deep lateral femoral notch: a sign of anterior cruciate ligament disruption. Mil Med. 2007 Jun.172(6):viii-viix. Pubmedid: 17615859.
    • Folio L, McHugh C, Hoffman MJ. The even-number guide and imaging ballistic injuries. Radiol Technol. 2007 Jan.78(3):197-203. Pubmedid: 17242440.
    • Ly JQ, Sanders TG, Folio L. Radiology corner. Answer to last month's radiology case and images: Schistosomiasis japonicum involving the liver and colon. Mil Med. 2007 Feb.172(2):xi-xii. Pubmedid: 17357784.
    • Sanghi A, Ly JQ, Bush RJ, Folio LR. Case for diagnosis. Elbow synovial fold syndrome. Mil Med. 2007 Dec.172(12):xii-xiii. Pubmedid: 18274035.
    • Folio LR, Yao EF. US military smallpox vaccination program: occupational impact of immunizations on aircrew in Air Mobility Command, US Air Force. J Am Osteopath Assoc. 2007 Dec.107(12):547-553. Pubmedid: 18178764.
    • Sanders TG, Duerden JD, Folio L. Answer to last month's radiology case and images (case # 5): The superior labrum, anterior-to-posterior 'SLAP' lesion. Mil Med. 2006 Oct.171(10):ix-ix. Pubmedid: 17076462.
    • Upton SJ, Ly JQ, Beall DP, Folio L. Radiology corner. Answer to last month's radiology case and image (case #6): hydroxyapatite deposition disease. Mil Med. 2006 Nov.171(11):ix-ix. Pubmedid: 17153560.
    • Folio L, Craig SH, Singleton B. Answer to last month's radiology case and image: emergency decompressive craniotomy with banked skull flap in subcutaneous pocket. Mil Med. 2006 Jun.171(6):vii-viii. Pubmedid: 16808145.
    • Ly JQ, Sanders TG, Smirniotopoulos JG, Folio L. Answer to last month's radiology case and image: Subdural hematoma. Mil Med. 2006 Jul.171(7):xi-xii. Pubmedid: 16895144.
    • Tillman BG, Folio LR, Choi JR. Answer to last month's radiology case and images (case # 7): colonic adenocarcinoma detected by virtual colonoscopy screening. Mil Med. 2006 Dec.171(12):v-vi. Pubmedid: 17256697.
    • Folio LR, Lahti RL, Cockrum DS, Bills S, Younker MR. Initial experience with mass immunization as a bioterrorism countermeasure. J Am Osteopath Assoc. 2004 Jun.104(6):240-243. Pubmedid: 15233330.
    • Hanson EH, Niemeyer DM, Folio L, Agan BK, Rowley RK. Potential use of microarray technology for rapid identification of central nervous system pathogens. Mil Med. 2004 Aug.169(8):594-599. Pubmedid: 15379069.
    • Folio L, Hanson E, Chao S. Generalizability of U.S. Air Force studies: 1990 and 2000 demographic distribution comparison of U.S. active duty Air Force personnel and the U.S. general population. Mil Med. 2002 Nov.167(11):911-919. Pubmedid: 12448617.
    • Otakeno S, Matthews RS, Folio L, Previc FH, Lessard CS. The effects of visual scenes on roll and pitch thresholds in pilots versus nonpilots. Aviat Space Environ Med. 2002 Feb.73(2):98-101. Pubmedid: 11858177.
    • Folio LR. Patient-controlled stress radiography of the thumb. Radiol Technol. 1999 May.70(5):465-469. Pubmedid: 10427591.
    • Folio LR. Hand vs. finger radiographs. Radiol Technol. 1996 Jan.67(3):249-250. Pubmedid: 8850257.
    • Folio LR. A mnemonic approach to the evaluation of chest x-ray films. J Am Osteopath Assoc. 1995 Nov.95(11):648. Pubmedid: 8575947.
    • Folio LR, Smith BF. Split screen contiguous ultrasound imaging. Radiol Technol. 1995 Mar.66(4):255. Pubmedid: 7784547.
    • Davis BA, Folio LR, Thibault MD, Laurente S. Pearls. Phys Sportsmed. 1995 Dec.23(12):27. Pubmedid: 29287492.
    • Folio L, Keller AS, Ianiro G, DiBacco R. Hook method of retrieving wire for fixation of osteotomies. J Am Podiatr Med Assoc. 1995 Dec.85(12):741-743. Pubmedid: 8592285.
    • Folio L, Rosenberg HK, Frishmuth GJ. Use of transperineal hydrosonovaginography to show an incomplete vaginal septum. Ajr Am J Roentgenol. 1992 Aug.159(2):343-344. Pubmedid: 1632352.
  • Grants

    Title: Automated De-Identification of Pathology and Radiology Data
    Sponsor: Nat Institutes of Health
    PI: Rasool, G., CO-PI: Folio, L., CO-PI: Bui, M., CO-PI: Farinhas, J.
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