Sam Reynolds, MD

Cancer Focus:
Leukemia, Myelodysplastic Syndromes (MDS)

Dr. Reynolds received his MD degree from the University of South Florida Morsani College of Medicine, Tampa, where he was inducted as member of the Robert A. Good Honor Society for his research contributions during medical school. He then completed an Internal Medicine Residency at the University of Louisville, Kentucky, where he also served as Chief Resident for Education. While in residency, Dr. Reynolds was the recipient of the professionalism award every year of his training, while also founding a resident research organization for the University of Louisville. He would go on to complete a Hematology/Oncology Fellowship at the University of Michigan, where he also served as the chief fellow. During fellowship, he was a recipient of a T32 grant and both the Veterans Affairs Kemp Cease and March Roth awards.

Dr. Reynolds’ clinical interests are in the diagnosis and management of myeloid neoplasms, including leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. He is also passionate about treating histiocytic neoplasms, including Erdheim Chester Disease, Langerhans Cell Histiocytosis and Rosai Dorfman Disease. His research interests focus on translational studies and early phase clinical trials examining the mechanisms underlying therapeutic resistance in myeloproliferative neoplasms and acute leukemias. Dr. Reynolds has published extensively in these disease areas and is always seeking to integrate cutting-edge research with patient care.

• Reynolds SB, Komrokji R, Kuykendall AT. The Ongoing Challenges of Managing Cytopenic Myelofibrosis in 2025: The Emergence of Non-JAK Inhibitor Therapies. Blood Lymphat Cancer. 2025 Sep.15:181-192. Pubmedid: 41030319. Pmcid: PMC12477285.
• Ali H, Reynolds S, Wilcox S, Chipalkatti N, Ahmed A. Circulating monocytes decrease significantly following disease-directed therapy and may reflect disease expansion in Langerhans Cell Histiocytosis. Ann Hematol. 2024 Dec.103(12):5123-5144. Pubmedid: 39190049.
• Reynolds SB, Pettit K. New approaches to tackle cytopenic myelofibrosis. Hematology Am Soc Hematol Educ Program. 2022 Dec.2022(1):235-244. Pubmedid: 36485113. Pmcid: PMC9820710.
• Nguyen QL, Reynolds SB, Piri N, Rivas Perez HL. Ophthalmic anterior segment metastasis masquerading as uveitis. BMJ Case Rep. 2021 Mar.14(3). Pubmedid: 33653830. Pmcid: PMC7929850.
• Lee TT, Durham ME, Demick DS, Reynolds SB, El-Mallakh RS. Increased infection rates associated with second-generation antipsychotics. Ann Clin Psychiatry. 2021 Feb.33(1):53-55. Pubmedid: 33577268.
• Reed K, Reynolds SB, Smith C. The First Case of Ignatzschineria ureiclastica/larvae in the United States Presenting as a Myiatic Wound Infection. Cureus. 2021 Apr.13(4):e14518. Pubmedid: 34007769. Pmcid: PMC8126268.
• Zetter DR, Kabir T, Reynolds SB. The Clinical Characteristics of Multiple Myeloma in the Acute Care Setting: Case Presentation and Clinical Recommendations. Cureus. 2020 Sep.12(9):e10463. Pubmedid: 33083166. Pmcid: PMC7566983.
• Krem MM, Reynolds SB, Hashmi H, Manapuram S, Jayswal R, Weiss HL, Baize TC, Figg LR, Basu SK, Monohan G, Herzig RH. The VR-DCEP regimen rescues mobilization failures and controls refractory disease in multiple myeloma. Bone Marrow Transplant. 2020 Jul.55(7):1451-1453. Pubmedid: 31705039.
• Miller G, Reynolds SB, Tse WW. Management of thrombocytopenia in a patient with a mechanical mitral valve undergoing autologous hematopoietic stem cell transplantation: case report and review of literature. Am J Blood Res. 2020 Feb.10(1):11-14. Pubmedid: 32206441. Pmcid: PMC7076283.
• Reynolds SB, Maghavani DP, Hashmi H. Acquired factor X deficiency in a patient with multiple myeloma: a rare case highlighting the significance of comprehensive evaluation and the need for antimyeloma therapy for bleeding diathesis. BMJ Case Rep. 2019 Sep.12(9). Pubmedid: 31527206. Pmcid: PMC6754647.
• Saeks J, Reynolds SB, Alexander JS, Ridley M. Bilateral Vocal Fold Paralysis After Epidural Anesthesia. Cureus. 2019 Mar.11(3):e4212. Pubmedid: 31114731. Pmcid: PMC6505725.
• Alexander JS, Hashmi H, Reynolds SB. Debilitating Metastatic Spindle Cell Carcinoma of the Breast. Cureus. 2019 Jan.11(1):e3864. Pubmedid: 30899615. Pmcid: PMC6414181.
• Reynolds SB, Hashmi H, Ngo P, Kloecker G. Rescue therapy for acute idiopathic thrombocytopenic purpura unresponsive to conventional treatment. BMJ Case Rep. 2019 Jan.12(1). Pubmedid: 30642865. Pmcid: PMC6340572.
• Sun Y, Gallacchi D, Zhang EY, Reynolds SB, Robinson L, Malinowska IA, Chiou TT, Pereira AM, Li C, Kwiatkowski DJ, Lee PS, Yu JJ. Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis. Am J Respir Cell Mol Biol. 2014 Dec.51(6):738-749. Pubmedid: 24874429. Pmcid: PMC4291547.
• Lee PS, Wilhelmson AS, Hubner AP, Reynolds SB, Gallacchi DA, Chiou TT, Kwiatkowski DJ. mTORC1-S6K activation by endotoxin contributes to cytokine up-regulation and early lethality in animals. PLoS One. 2010 Dec.5(12):e14399. Pubmedid: 21200439. Pmcid: PMC3006197.