Department Metrics
View the grants, clinical trials and publications from the Molecular Oncology Department.
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Grants
- Anti-tumor Potential of Temperature-Sensitive p53 Mutants
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Sponsor: Nat Institutes of Health
PI (Contact):Chen, J.,PI:Mann, M. - Identifying Metabolic Vulnerabilities in Lung Cancer
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Sponsor: Nat Institutes of Health
PI (Contact):Flores, E.,PI (MPI):Haura, E.,Project PI:DeNicola, G.,Project PI:Rodriguez, P.,Project PI:Cleveland, J. - Chromosome 1q ceRNAs in melanoma progression and metastasis
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Sponsor: Nat Institutes of Health
PI:Karreth, F. - Biophysical basis for enzyme mediated deglycation in protein repair
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Sponsor: Nat Institutes of Health
PI:Binning, J. - Biophysical basis for enzyme mediated deglycation in protein repair
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Sponsor: Nat Institutes of Health
PI:Binning, J. - Characterizing oncogenic function of ITCH in melanoma
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Sponsor: Nat Institutes of Health
PI:Wan, L. - Targeting centrosome‐mitotic kinases as a novel therapeutic approach against breast cancers in Hispanic/Latinas
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Sponsor: Nat Institutes of Health
PI (MPI):Cress, D. - Elucidating the Oncogenic Role of sMAF Proteins in Melanoma
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Sponsor: Amer Cancer Society
PI:Karreth, F. - Allosteric Regulation of MDMX by Protein Disorder
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Sponsor: Nat Institutes of Health
PI (Contact):Chen, J. - Employing functionalized fragment libraries to identify therapeutic agents for neurofibromatosis type 2
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Sponsor: Nat Institutes of Health
PI:Kissil, J. - RBFOX2 deregulation promotes pancreatic cancer progression through alternative splicing
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Sponsor: Nat Institutes of Health
PI:Mann, K. - Targeting Wnt Signaling Pathway
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Sponsor: Nat Institutes of Health
PI:Chen, J. - Restoring FZR1 Tumor Suppressor Function in Human Cancers
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Sponsor: Florida Biomedical Research Program (FBRP)
PI:Wan, L. - Understanding the mechanisms by which STK11 loss in lung cancer leads to immune invasion
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Sponsor: Florida Biomedical Research Program (FBRP)
PI:Cress, D. - Defining the glyco-RNAome in melanoma progression
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Sponsor: US Army
PI:Karreth, F. - Community Project Funding/Congressionally Directed Spending ‐ Construction
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Sponsor: Dept of Health & Human Services (DHHS)
PI:Flores, E. - Targeting a PHGDH Metabolic Vulnerability in Melanoma
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Sponsor: Nat Institutes of Health
PI:Karreth, F. - Targeting antioxidant vulnerabilities in KEAP1/NRF2 mutant NSCLC
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Sponsor: Nat Institutes of Health
PI:Jiang, C. - Novel genetic mouse models of uveal melanoma progression and metastasis
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Sponsor: US Army
PI:Karreth, F. - Interrogating the relationship between translational dynamics and non-canonical antigen presentation in lung cancer
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Sponsor: Nat Institutes of Health
PI:Jaeger, A. - Chromosome 1q ceRNAs in melanoma progression and metastasis
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Sponsor: Nat Institutes of Health
PI:Karreth, F. - Elucidating the oncogenic role of sMAF proteins in melanoma (supplement)
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Sponsor: Amer Cancer Society
PI:Karreth, F. - Mapping the antigenic landscape of lung cancer following KRAS inhibition
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Sponsor: Amer Lung Assoc
PI:Jaeger, A. - Engineering approaches to exploit MHC-II antigen presentation in cancer
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Sponsor: Damon Runyon Cancer Research Inst
PI:Jaeger, A.
- Anti-tumor Potential of Temperature-Sensitive p53 Mutants
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Publications
- Elzaafarany O, Lester D, Mokhtari S, Kissil JL. NF2-associated schwannomatosis (NF2): genetics, manifestations, and emerging therapeutic approaches. Trends Mol Med. 2025 Dec.31(12):1154-1155. Pubmedid: 40885618. Pmcid: PMC12404673.
- Mattavelli G, Helal M, Cetkovic A, Krämer MJ, Herbert SL, Mielert K, Schlaiß T, Frank A, Riemer E, John M, Del Pilar J, Vasquez M, Kindl L, Swietlik JJ, Gansen BO, Krafft M, Stanojkovska E, Fischer H, Albert US, Bauer J, Delgobo M, Aintablian A, Alattar H, Lutz MB, Meissner F, Oskarsson T, Rasche L, Ramos G, Rosenwald A, Wöckel A, Riedel A. A TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer. Immunity. 2025 Nov.58(11):2830-2846.e15. Pubmedid: 40957419.
- Smalley TB, Nicolaci AA, Tran KC, Lokhandwala J, Obertopp N, Matlack JK, Miner RE, Teng MN, Pilon-Thomas S, Binning JM. Targeted degradation of the HPV oncoprotein E6 reduces tumor burden in cervical cancer. Mol Ther. 2025 Nov.33(11):5415-5426. Pubmedid: 40873032. Pmcid: PMC12582245.
- Chen L, Shultz ZP, Sansone M, Fang B, Liu X, Teng M, Schonbrunn E, Lopchuk JM, Chen J. PROTAC-Mediated Degradation of TAF1 Induces Apoptosis in AML Cells and Inhibits Tumor Growth In Vivo. Mol Cancer Ther. 2025 Nov.24(11):1712-1721. Pubmedid: 40376796. Pmcid: PMC12353786.
- Son J, Remsing Rix LL, Fang B, Welsh EA, Bremer NV, Foglizzo V, Roa P, Sigcha-Coello N, Liao Y, Haura EB, Drilon A, Koomen JM, Cocco E, Rix U. Dual targeting of RET and SRC synergizes in RET fusion-positive cancer cells. Mol Oncol. 2025 Nov. Pubmedid: 41194587.
- Hortin GL, Koomen JM. Evaluation of Proteinuria in Plasma Cell Disorders: Shortcomings of Measurements Based on 24-Hour Collections and Alternative Approaches. J Appl Lab Med. 2025 Nov.10(6):1664-1674. Pubmedid: 40928885.
- Underwood MT, Devarapalli V, Jinesh GG, Lockhart JH, Napoli M, Mtchedlidze N, Flores ER, Brohl AS. The Chromosome 19 microRNA Cluster Facilitates Cancer Stemness in Hepatocellular Carcinoma. Noncoding RNA. 2025 Oct.11(6). Pubmedid: 41283329. Pmcid: PMC12641929.
- Jinesh G, Mtchedlidze N, Devarapalli V, Adhikary S, Lockhart J, Napoli M, Isha I, Reiser M, Cen L, Liu X, Yoder S, Mesa T, Flores E, Brohl A. CEBPB, C19MC, and Defective Autophagy Drive Novel Podosomal Belt to Macropinocytosis Transition, Lipid Accumulation, and HBV A-to-I RNA-editing. Res Sq. 2025 Oct. Pubmedid: 41282072. Pmcid: PMC12636704.
- Colin-Leitzinger C, Mekonnen YA, Narvaez-Bandera I, Rubio VY, Ercan D, Welsh EA, Darville LNF, Liu M, Ackerman HD, Avila-Pacheco J, Clish CB, Hicks K, Koomen JM, Gillis N, Fridley BL, Flores ER, Zeleznik OA, Stewart PA. A machine learning framework for classifying lipids in untargeted metabolomics using mass-to-charge ratios and retention times. Metabolomics. 2025 Oct.21(6):151. Pubmedid: 41109916. Pmcid: PMC12535499.
- Wang M, Bieging-Rolett KT, Kaiser AM, Brady CA, Lockhart JH, Ferreira S, Nguyen KT, Rajeevan A, Evans SA, Zhao T, Raj N, Elkrief A, Tischfield SE, Ladanyi M, Ozawa MG, Bui NQ, Chen CT, Flores ER, Attardi LD. p53 drives lung cancer regression through a TSC2/TFEB-dependent senescence program. Cancer Discov. 2025 Oct. Pubmedid: 41115251.
- Solanki HS, Shah H, Imbody D, Desai B, Kato R, Miroshnychenko D, Stern YE, Majumder A, Sarcar B, Xieraili A, Stewart PA, Fang B, Zhang Y, Yao J, Darville LN, Koomen JM, Rix U, Evans JW, Yang YC, Ahler E, Marusyk A, Singh M, Aronchik I, Haura EB. RAS-GTP Inhibition Overcomes Acquired Resistance to KRASG12C Inhibitors Mediated by Oncogenic and Wildtype RAS Activation in Non-Small Cell Lung Cancer. Cancer Res. 2025 Oct. Pubmedid: 41165456.
- Chadourne M, Griffith C, Jasani N, Xu X, Brennan E, Vera O, Mecozzi N, Wang K, Jaeger AM, Karreth FA. CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma. Cell Rep. 2025 Oct.44(10):116362. Pubmedid: 41037395. Pmcid: PMC12588357.
- Davis EW, Park MA, Basinski TL, Arnoletti JP, Bloomston M, Carson TL, Biachi De Castria T, Chen DT, Cortizas EM, Crowder SL, Genilo-Delgado M, Douglas WG, Huguet KL, Jiang K, Hodul PJ, Karolak A, Kim DW, Koomen JM, Menon AA, Mo Q, Mok SR, Molina-Vega MA, Moreno-Urazan L, Ahmed S, Parker NH, Pimiento JM, Rasool G, Sparks LM, Stewart PA, Tassielli AF, Teer JK, Trevino JG, Velanovich V, Wang X, Whelan CJ, Judge SM, Judge AR, Fleming JB, Malafa MP, Jeong D, Permuth JB. The Impact of Edema on Skeletal Muscle Changes among Patients with Pancreatic Ductal Adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2025 Sep.34(9):1609-1617. Pubmedid: 40553455.
- Matlack JK, Miner RE, Lokhandwala J, Binning JM. Ancestral protein reconstruction reveals the mechanism of substrate specificity in FN3K-mediated deglycation. Res Sq. 2025 Sep. Pubmedid: 41041572. Pmcid: PMC12486099.
- Shepard A, Lester DK, Troutman S, Hoxha S, Khaled WT, Smith ESJ, Park TJ, Buffenstein R, Du D, Teng M, Dengler-Crish CM, Tsai KY, Flores ER, Ventura A, Kissil JL. An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole-Rat. Cancer Discov. 2025 Sep. Pubmedid: 40920097. Pmcid: PMC12486303.
- Parkman GL, Xu X, Holmen SL, Karreth FA. The Roles of PTEN in Melanoma Suppression. Pigment Cell Melanoma Res. 2025 Sep.38(5):e70054. Pubmedid: 40976930. Pmcid: PMC12451098.
- Crawford KJ, Humphrey KS, Cortes E, Wang J, Kumarasamy V, Wan Y, Long MD, Feigin ME, Witkiewicz AK, Mann KM, Knudsen ES, Abel EV. Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma. Mol Cancer. 2025 Jul.24(1):208. Pubmedid: 40731412. Pmcid: PMC12306140.
- Matlack JK, Miner RE, Lokhandwala J, Binning JM. Ancestral protein reconstruction reveals the mechanism of substrate specificity in FN3K-mediated deglycation. bioRxiv. 2025 Jul. Pubmedid: 40766467. Pmcid: PMC12324494.
- Bishop RT, Li T, Sudalagunta P, Nasr M, Nyman KJ, Alugubelli RR, Meads M, Frieling J, Nerlakanti N, Tauro M, Fang B, Grant S, Koomen J, Silva AS, Shain KH, Lynch CC. Acid ceramidase controls proteasome inhibitor resistance and is a novel therapeutic target for the treatment of relapsed/refractory multiple myeloma. Haematologica. 2025 Jun.110(6):1351-1367. Pubmedid: 39633543. Pmcid: PMC12130774.
- Gao Y, Yin Q, Gamallat Y, Grant MG, Snell AH, Shi X, Ulstad LN, Singh A, Chen T, Johnson JO, Avram D, Wan L. Linear ubiquitination of p31comet by HOIP couples cytokine response with mitotic regulation. Cell Biosci. 2025 Jun.15(1):75. Pubmedid: 40462232. Pmcid: PMC12135451.
- Xu X, Liu X, Dollar JJ, Liu X, Jasani N, Posorske B, Sriramareddy SN, Jarajapu V, Kuznetsoff JN, Sinard J, Bennett RL, Licht JD, Smalley KSM, Harbour JW, Yu X, Karreth FA. A multi-step immune-competent genetic mouse model reveals phenotypic plasticity in uveal melanoma. bioRxiv. 2025 Jun. Pubmedid: 40502063. Pmcid: PMC12157397.
- Xu X, Chadourne M, Soto-Vargas Z, Jarajapu V, Yao J, Yu X, Karreth FA. FRA1 drives melanoma metastasis through an actionable transcriptional network. bioRxiv. 2025 Jun. Pubmedid: 40661443. Pmcid: PMC12258986.
- Srivastava J, Yadav VK, Jimenez RV, Phadatare PR, Inamdar NA, Young MM, Bacchiocchi A, Halaban R, Fang B, Pulido AM, Tsai KY, Smalley KSM, Koomen JM, Rodriguez PC, Premi S. Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors. Cancer Res. 2025 Jun.85(12):2268-2287. Pubmedid: 40287947. Pmcid: PMC12167936.
- Lantz AE, Gordián ER, Rosa M, Rodríguez Ruíz M, Johnson JO, Gebert R, Bahr A, Chen DT, Dutil J, Li J, Oliveras Torres JA, Saavedra HI, Eschrich SA, Flores I, Cress WD. Creation and Characterization of a Breast Cancer Tissue Microarray Including Black and White Patients from Florida and Hispanic Patients from Puerto Rico and Florida. Cancer Res Commun. 2025 May.5(5):804-813. Pubmedid: 40309949. Pmcid: PMC12082392.
- Wang C, Yu X, Teer JK, Yao J, Du D, Liu X, Thompson ZJ, Wang MH, Welsh EA, Memon D, Chan TA, Makarov V, Anadon CM, Saeed L, Boyle TA, Fang B, Koomen JM, Cox C, Landin AM, Yoder SJ, Kim S, Chen DT, Pilon-Thomas SA, Conejo-Garcia JR, Antonia SJ, Haura EB, Creelan BC. Impaired T cell and neoantigen retention in time-serial analysis of metastatic non-small cell lung cancer in patients unresponsive to TIL cell therapy. Nat Cancer. 2025 May.6(5):801-819. Pubmedid: 40341231.
- Nagai R, Milam OL, Niwa T, Howell WJ, Best JA, Yoshida H, Freeburg CD, Koomen JM, Fujii K. Ribosomal expansion segment contributes to translation fidelity via N-terminal processing of ribosomal proteins. Nucleic Acids Res. 2025 May.53(10). Pubmedid: 40433980. Pmcid: PMC12117404.
- Ramamoorthi G, Lee MC, Farrell CM, Snyder C, Garg SK, Aldrich AL, Lok V, Dominguez-Viqueira W, Olson-Mcpeek SK, Rosa M, Gautam N, Pilon-Thomas S, Cen L, Kodumudi KN, Wiener D, Oskarsson T, Gomes AP, Gatenby RA, Czerniecki BJ. Antitumor CD4+ T Helper 1 Cells Target and Control the Outgrowth of Disseminated Cancer Cells. Cancer Immunol Res. 2025 May.13(5):729-748. Pubmedid: 40249209. Pmcid: PMC12046335.
- Matejcic M, Teer JK, Hoehn HJ, Diaz DB, Shankar K, Gong J, Nguyen NT, Loroña NC, Coppola D, Fulmer CG, Saglam O, Jiang K, Cress WD, Muñoz-Antonia T, Flores I, Gordián ER, Oliveras Torres JA, Felder SI, Sanchez J, Fleming JB, Siegel EM, Freedman JA, Dutil J, Stern MC, Fridley BL, Figueiredo JC, Schmit SL. Colorectal Tumors in Diverse Patient Populations Feature a Spectrum of Somatic Mutational Profiles. Cancer Res. 2025 May.85(10):1928-1944. Pubmedid: 40126181. Pmcid: PMC12234169.
- Freeman CL, Noble J, Menges M, Villanueva R, Nakashima JY, Figura NB, Tonseth RP, Idiaquez DW, Skelson L, Smith EC, Abraham-Miranda J, Corallo S, De Avila G, Castaneda Puglianini O, Liu HD, Alsina M, Nishihori T, Shain KH, Baz RC, Blue BJ, Grajales-Cruz A, Koomen JM, Atkins RM, Hansen DK, Siqueira Silva A, Kim J, Balagurunathan Y, Locke FL. Tumor burden quantified by soluble B-cell maturation antigen and metabolic tumor volume determines myeloma CAR-T outcomes. Blood. 2025 Apr.145(15):1645-1657. Pubmedid: 39652773.
- Schmit SL, Loroña NC, Sobieski D, Matejcic M, Nguyen NT, Hoehn HJ, Diaz DB, Shankar K, Cockman EM, Jean-Baptiste E, Tsai YY, Buchalter RB, Brito K, Wilson R, Coppola D, Fulmer C, Saglam O, Tassielli AF, Beato F, Dai R, Freedman JA, Purrington K, Hu B, Mcgrail D, Gibson H, Jiang K, Muñoz-Antonia T, Flores I, Gordian E, Oliveras Torres JA, Cheng I, Van Blarigan EL, Felder SI, Sanchez JA, Fleming JB, Siegel EM, Cress D, Thompson P, Stern MC, Teer JK, Figueiredo JC. Building research infrastructure to advance precision medicine in colorectal cancer. JNCI Cancer Spectr. 2025 Apr.9(3). Pubmedid: 40111849. Pmcid: PMC12140009.
- Nowicka Z, Rentzeperis F, Tagal V, Teer JK, Ilter D, Beck RJ, Cole JP, Forero Pinto AM, Tejero JD, Scanu E, Veith T, Dominguez-Viqueira W, Maksin K, Carrillo-Perez FM, Gevaert O, Xu X, Karreth FA, Abdalah MA, Fiandaca G, Pasetto S, Prabhakaran S, Schultz A, Ojwang' AME, Barnholtz-Sloan JS, Farinhas JM, Gomes AP, Katira P, Andor N. Interactions between Ploidy and Resource Availability Shape Clonal Evolution in Glioblastoma. Cancer Res. 2025 Apr.85(8):1544-1559. Pubmedid: 39933186.
- Davila M, Lee SB, Kang YP, Boucher J, Mandula J, Roselli E, Chang D, Jimenez R, Kotani H, Reid K, Vazquez-Martinez J, Beatty N, Goala P, Sierra-Mondragon R, Liu M, Koomen J, Nguyen J, Hussaini M, Shaw T, Wang X, Faramand R, Jain M, Locke F, Rodriguez P, Sailer C, McSain S, Hamid S, Tariq M, Wang J, Abraham-Miranda J. CAR T cell-driven induction of iNOS in tumor-associated macrophages promotes CAR T cell resistance in B cell lymphoma. Res Sq. 2025 Mar. Pubmedid: 40235478. Pmcid: PMC11998770.
- Permuth J, Park M, Davis E, Alhassan S, Arnoletti J, Basinski T, McKee A, Bloomston M, Carson T, de Castria TB, Chen DT, Cortizas E, Crowder S, Delgado MG, Douglas W, Fleming J, Hodul P, Huguet K, Jiang K, Kim DW, Koomen J, Luthra A, Malafa M, Menon A, Morales R, Merchant N, Meredith K, Mo Q, Molina-Vega M, Moreno-Urazan L, Olumoyin K, Parker N, Pimiento J, Rasool G, Rejniak K, Sansil S, Sparks L, Stewart P, Tassielli A, Teer J, Tran DV, Trevino J, Velanovich V, Whelan C, Jeong D, Judge S, Judge A. Race-based differences in serum biomarkers for cancer-associated cachexia in a diverse cohort of patients with pancreatic ductal adenocarcinoma. Res Sq. 2025 Feb. Pubmedid: 39989973. Pmcid: PMC11844656.
- Guergues J, Wohlfahrt J, Koomen JM, Krieger JR, Varma S, Stevens SM. A semi-automated workflow for DIA-based global discovery to pathway-driven PRM analysis. Proteomics. 2025 Feb.25(3):e2400129. Pubmedid: 39235396. Pmcid: PMC11798701.
- Jasani N, Xu X, Posorske B, Kim Y, Wang K, Vera O, Tsai KY, DeNicola GM, Karreth FA. PHGDH Induction by MAPK Is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability. Cancer Res. 2025 Jan.85(2):314-328. Pubmedid: 39495254. Pmcid: PMC11735329.
- Mann KM. POGK is a domesticated KRAB domain-containing transposable element with tumor suppressive functions in breast cancer. Trends Cell Biol. 2025 Jan.35(1):4-5. Pubmedid: 39547880.
- García-Irizarry KD, Rojas-Brenes ME, Oliveras-Torres JA, Ortiz-Ortiz CN, Cress WD, Gordián E, Martínez RG, Quintana-González FJ, Escobar-Rodríguez PF, Muñoz-Antonia T, Flores I. Profiling Sociodemographic Risk Factors and Clinical Outcomes of Women with Endometrial Cancer in Puerto Rico: The Central Role of Obesity and Obstetric Features. J Racial Ethn Health Disparities. 2025 Jan. Pubmedid: 39833653.
- Lazure F, Drapela S, Liu X, Lockhart JH, Kashfi H, Sarigul N, Ilter D, Flores ER, Wang X, Smalley I, Jaeger A, Yu X, Gomes AP. Aging directs the differential evolution of KRAS-driven lung adenocarcinoma. bioRxiv. 2025 Jan. Pubmedid: 39896625. Pmcid: PMC11785146.
- Chadourne M, Griffith C, Xu X, Brennan E, Vera O, Mecozzi N, Wang K, Jaeger AM, Karreth FA. CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma. bioRxiv. 2024 Dec. Pubmedid: 39764055. Pmcid: PMC11703152.
- Shao A, Kissil JL, Fan CM. The L27 domain of MPP7 enhances TAZ-YY1 cooperation to renew muscle stem cells. EMBO Rep. 2024 Dec.25(12):5667-5686. Pubmedid: 39496834. Pmcid: PMC11624273.
- Narváez-Bandera I, Lui A, Ayalew Mekonnen Y, Rubio V, Sulman N, Wilson C, Ackerman HD, Ospina OE, Gonzalez-Calderon G, Flores E, Li Q, Chen A, Fridley B, Stewart P. iModMix: Integrative Module Analysis for Multi-omics Data. bioRxiv. 2024 Dec. Pubmedid: 39605665. Pmcid: PMC11601443.