Mitchell Hayes, MD

Associations

• Genitourinary Oncology

Dr. Hayes’ clinical interests are in genitourinary cancers, including prostate, bladder, kidney, testicular, and penile malignancies, with a special interest in kidney and bladder cancer. His research investigates the tumor immune microenvironment of kidney cancer, with a special interest in spatial tissue analysis and biomarker discovery.  

• Sandberg M, Russell G, Feldman D, Hayes M, David RB, Miller J, Patel K, Aljabi B, Byun SS, Faba OR, Cannoletta D, Letowski T, Villoldo G, Marchinena PG, Mourao T, Ciancio G, Peyton CC, Zanotti R, Chang S, Spiess PE, Mehrazin R, Abreu D, Zequi SC, Rodriguez A. Impact of Systemic Therapy for Renal Cell Carcinoma With a Tumor Thrombus: Results From the Intercontinental Collaboration on Renal Cell Carcinoma Database. Clin Genitourin Cancer. 2025 Sep.102442. Pubmedid: 41125506.
• Sandberg M, Vancavage R, Marie-Costa C, Ye E, Hayes M, Miller J, Ben David R, Patel K, Waggener K, Aljabi B, Byun S, García Marchiñena P, Mourao T, Peyton C, Mehrazin R, Spiess P, Zanotti R, Chang S, Zequi SC, Abreu D, Rodriguez A. A comparison of renal cell carcinoma with tumor thrombus across North America, Central/South America, and South Korea. Arch Ital Urol Androl. 2025 Jun.97(2):13820. Pubmedid: 40491291.
• Sandberg M, Russell G, Malakismail J, Hayes M, David RB, Miller J, Patel K, Aljabi B, Byun SS, Faba OR, Cannoletta D, Letowski T, Villoldo G, Marchinena PG, Mourao T, Ciancio G, Peyton CC, Zanotti R, Spiess PE, Mehrazin R, Abreu D, de Cassio Zequi S, Rodriguez A. Correction: A comparison of open, laparoscopic, and robotic radical nephrectomy with tumor thrombectomy from the intercontinental collaboration on renal cell carcinoma. J Robot Surg. 2025 Jun.19(1):317. Pubmedid: 40549112. Pmcid: PMC12185551.
• May AM, Kadomoto S, Williams C, Soupir AC, The S, McGue JJ, Robinson T, Shelley G, Hayes MT, Fridley BL, Balasi JA, Ramos Echevarria PM, Dhillon J, Nallandhighal S, Acharyya S, Chen L, Aldous J, Schurman N, Baladandayuthapani V, Frankel TL, Salami SS, Manley BJ, Mehra R, Udager AM, Keller ET. Spatial analysis reveals a novel inflammatory tumor transition state which promotes a macrophage-driven induction of sarcomatoid renal cell carcinoma. bioRxiv. 2025 Jun. Pubmedid: 40661608. Pmcid: PMC12259133.
• Sandberg M, Russell G, Malakismail J, Hayes M, David RB, Miller J, Patel K, Aljabi B, Byun SS, Faba OR, Cannoletta D, Letowski T, Villoldo G, Marchinena PG, Mourao T, Ciancio G, Peyton CC, Zanotti R, Spiess PE, Mehrazin R, Abreu D, de Cassio Zequi S, Rodriguez A. A comparison of open, laparoscopic, and robotic radical nephrectomy with tumor thrombectomy from the intercontinental collaboration on renal cell carcinoma. J Robot Surg. 2025 Jun.19(1):269. Pubmedid: 40467927. Pmcid: PMC12137462.
• Guske C, Immen N, Conant D, Laborde J, Linscott J, Hayes M, Jazayeri SB, Fazili A, Siegel E, Dessureault S, Sanchez J, Stefanou A, Manley B, Felder S. Short- and Intermediate-Term Morbidity Following Total Pelvic Exenteration in Colorectal Cancer. Cancer Control. 2025 Jan.32. Pubmedid: 39848249. Pmcid: PMC11758541.
• Wrobel J, Soupir AC, Hayes MT, Peres LC, Vu T, Leroux A, Fridley BL. mxfda: a comprehensive toolkit for functional data analysis of single-cell spatial data. Bioinform Adv. 2024 Nov.4(1):vbae155. Pubmedid: 39552929. Pmcid: PMC11568348.
• Soupir AC, Hayes MT, Peak TC, Ospina O, Chakiryan NH, Berglund AE, Stewart PA, Nguyen J, Segura CM, Francis NL, Echevarria PMR, Chahoud J, Li R, Tsai KY, Balasi JA, Peres YC, Dhillon J, Martinez LA, Gloria WE, Schurman N, Kim S, Gregory M, Mulé J, Fridley BL, Manley BJ. Increased spatial coupling of integrin and collagen IV in the immunoresistant clear-cell renal-cell carcinoma tumor microenvironment. Genome Biol. 2024 Dec.25(1):308. Pubmedid: 39639369. Pmcid: PMC11622564.
• Sandberg M, Namugosa M, Ritts R, Costa CM, Temple D, Hayes M, Whitman W, Ye E, Refugia J, Ben-David R, Alerasool P, Eilender B, Zanotti RR, Mourão TC, Kim JK, Marchiñena PG, Byun SS, Abreu D, Mehrazin R, Spiess P, de Cassio Zequi S, Rodriguez A. The role of preoperative immune cell metrics in renal cell carcinoma with a tumor thrombus. Urologia. 2024 Aug.91(3):477-485. Pubmedid: 38661082.

• Title: Tracing the Seeds of Progression: Spatial Transcriptomic Analysis of Immunoresistant Kidney Cancer
  Award Number: KCA-2024-TRAIL-003
  Sponsor: KIDNEY CANCER ASSOCIATION
  Hayes, M. (PD/PI)
• Title: Quantifying Spatial Properties of Immunosuppressive Macrophages in Papillary Renal Cell Carcinoma
  Award Number: HT9425-25-1-0310
  Sponsor: Department of Defense (DOD)
  Hayes, M. (PD/PI)