Mitchell Hayes, MD

Associations

• Genitourinary Oncology

Dr. Hayes’ clinical interests are in genitourinary cancers, including prostate, bladder, kidney, testicular, and penile malignancies, with a special interest in kidney and bladder cancer. His research investigates the tumor immune microenvironment of kidney cancer, with a special interest in spatial tissue analysis and biomarker discovery.  

• Sandberg M, Russell G, Krol P, Hayes M, Bissette R, Ben David R, Patel K, Aljabi B, Byun SS, Faba OR, Marchinena PG, Mourao T, Ciancio G, Peyton CC, Zanotti R, Spiess PE, Mehrazin R, Rais-Bahrami S, Abreu D, Zequi SC, Rodriguez AR. Comparing Cytoreductive Nephrectomy with Tumor Thrombectomy Between Open, Laparoscopic, and Robotic Approaches. Cancers (Basel). 2025 Oct.17(21). Pubmedid: 41228283. Pmcid: PMC12608616.
• Sandberg M, Vancavage R, Marie-Costa C, Ye E, Hayes M, Miller J, Ben David R, Patel K, Waggener K, Aljabi B, Byun S, García Marchiñena P, Mourao T, Peyton C, Mehrazin R, Spiess P, Zanotti R, Chang S, Zequi SC, Abreu D, Rodriguez A. A comparison of renal cell carcinoma with tumor thrombus across North America, Central/South America, and South Korea. Arch Ital Urol Androl. 2025 Jun.97(2):13820. Pubmedid: 40491291.
• Sandberg M, Russell G, Malakismail J, Hayes M, David RB, Miller J, Patel K, Aljabi B, Byun SS, Faba OR, Cannoletta D, Letowski T, Villoldo G, Marchinena PG, Mourao T, Ciancio G, Peyton CC, Zanotti R, Spiess PE, Mehrazin R, Abreu D, de Cassio Zequi S, Rodriguez A. Correction: A comparison of open, laparoscopic, and robotic radical nephrectomy with tumor thrombectomy from the intercontinental collaboration on renal cell carcinoma. J Robot Surg. 2025 Jun.19(1):317. Pubmedid: 40549112. Pmcid: PMC12185551.
• May AM, Kadomoto S, Williams C, Soupir AC, The S, McGue JJ, Robinson T, Shelley G, Hayes MT, Fridley BL, Balasi JA, Ramos Echevarria PM, Dhillon J, Nallandhighal S, Acharyya S, Chen L, Aldous J, Schurman N, Baladandayuthapani V, Frankel TL, Salami SS, Manley BJ, Mehra R, Udager AM, Keller ET. Spatial analysis reveals a novel inflammatory tumor transition state which promotes a macrophage-driven induction of sarcomatoid renal cell carcinoma. bioRxiv. 2025 Jun. Pubmedid: 40661608. Pmcid: PMC12259133.
• Sandberg M, Russell G, Malakismail J, Hayes M, David RB, Miller J, Patel K, Aljabi B, Byun SS, Faba OR, Cannoletta D, Letowski T, Villoldo G, Marchinena PG, Mourao T, Ciancio G, Peyton CC, Zanotti R, Spiess PE, Mehrazin R, Abreu D, de Cassio Zequi S, Rodriguez A. A comparison of open, laparoscopic, and robotic radical nephrectomy with tumor thrombectomy from the intercontinental collaboration on renal cell carcinoma. J Robot Surg. 2025 Jun.19(1):269. Pubmedid: 40467927. Pmcid: PMC12137462.
• Guske C, Immen N, Conant D, Laborde J, Linscott J, Hayes M, Jazayeri SB, Fazili A, Siegel E, Dessureault S, Sanchez J, Stefanou A, Manley B, Felder S. Short- and Intermediate-Term Morbidity Following Total Pelvic Exenteration in Colorectal Cancer. Cancer Control. 2025 Jan.32. Pubmedid: 39848249. Pmcid: PMC11758541.
• Sandberg M, Russell G, Feldman D, Hayes M, David RB, Miller J, Patel K, Aljabi B, Byun SS, Faba OR, Cannoletta D, Letowski T, Villoldo G, Marchinena PG, Mourao T, Ciancio G, Peyton CC, Zanotti R, Chang S, Spiess PE, Mehrazin R, Abreu D, Zequi SC, Rodriguez A. Impact of Systemic Therapy for Renal Cell Carcinoma With a Tumor Thrombus: Results From the Intercontinental Collaboration on Renal Cell Carcinoma Database. Clin Genitourin Cancer. 2025 Dec.23(6):102442. Pubmedid: 41125506.
• Wrobel J, Soupir AC, Hayes MT, Peres LC, Vu T, Leroux A, Fridley BL. mxfda: a comprehensive toolkit for functional data analysis of single-cell spatial data. Bioinform Adv. 2024 Nov.4(1):vbae155. Pubmedid: 39552929. Pmcid: PMC11568348.
• Soupir AC, Hayes MT, Peak TC, Ospina O, Chakiryan NH, Berglund AE, Stewart PA, Nguyen J, Segura CM, Francis NL, Echevarria PMR, Chahoud J, Li R, Tsai KY, Balasi JA, Peres YC, Dhillon J, Martinez LA, Gloria WE, Schurman N, Kim S, Gregory M, Mulé J, Fridley BL, Manley BJ. Increased spatial coupling of integrin and collagen IV in the immunoresistant clear-cell renal-cell carcinoma tumor microenvironment. Genome Biol. 2024 Dec.25(1):308. Pubmedid: 39639369. Pmcid: PMC11622564.
• Sandberg M, Namugosa M, Ritts R, Costa CM, Temple D, Hayes M, Whitman W, Ye E, Refugia J, Ben-David R, Alerasool P, Eilender B, Zanotti RR, Mourão TC, Kim JK, Marchiñena PG, Byun SS, Abreu D, Mehrazin R, Spiess P, de Cassio Zequi S, Rodriguez A. The role of preoperative immune cell metrics in renal cell carcinoma with a tumor thrombus. Urologia. 2024 Aug.91(3):477-485. Pubmedid: 38661082.
• Soupir AC, Hayes MT, Peak TC, Ospina O, Chakiryan NH, Berglund AE, Stewart PA, Nguyen J, Segura CM, Francis NL, Echevarria PMR, Chahoud J, Li R, Tsai KY, Balasi JA, Peres YC, Dhillon J, Martinez LA, Gloria WE, Schurman N, Kim S, Gregory M, Mulé J, Fridley BL, Manley BJ. Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironment. bioRxiv. 2023 Nov. Pubmedid: 38014063. Pmcid: PMC10680839.
• Hayes M, Yu Y, Bassale S, Chakiryan N, Chen Y, Ye S, Garzotto M, Kopp R. Calibrated Regression Models Based on the Risk of Clinical Nodal Metastasis Should be Used as Decision Aids for Prostate Cancer Staging to Reduce Unnecessary Imaging. Clin Genitourin Cancer. 2022 Dec.20(6):e490-e497. Pubmedid: 35649886.
• Hayes M, Patel A, Seideman C. Staged Fowler Stephens, Who Requires a Third Procedure?. Curr Urol Rep. 2021 May.22(6):32. Pubmedid: 34009488.
• Hayes M, Lin-Brande M, Isharwal S. Primary Focal Therapy for Localized Prostate Cancer: A Review of the Literature. Oncology (Williston Park). 2021 May.35(5):261-268. Pubmedid: 33983695.
• Jiang DD, Hayes M, Gillis KA, Korets R, Wagner AA, Hedges JC, Chakiryan NH. Misaligned Incentives in Benign Prostatic Enlargement Surgery: More Complex and Efficacious Procedures Are Earning Fewer Relative Value Units. J Endourol. 2021 Jun.35(6):835-839. Pubmedid: 33222524.
• Hayes M, Schlundt D, Bonnet K, Vogus TJ, Kripalani S, Froehler MT, Ward MJ. Tales from the Trips: A Qualitative Study of Timely Recognition, Treatment, and Transfer of Emergency Department Patients with Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2019 May.28(5):1219-1228. Pubmedid: 30745000. Pmcid: PMC6467718.
• Alvarado MD, Conolly J, Park C, Sakata T, Mohan AJ, Harrison BL, Hayes M, Esserman LJ, Ozanne EM. Patient preferences regarding intraoperative versus external beam radiotherapy following breast-conserving surgery. Breast Cancer Res Treat. 2014 Jan.143(1):135-140. Pubmedid: 24292868.
• Esserman L, Hayes M, Alvarado M. Haste makes waste, but lack of urgency is opportunity lost. Breast Cancer Res Treat. 2014 Aug.147(1):223-224. Pubmedid: 25062705.

• Title: Tracing the Seeds of Progression: Spatial Transcriptomic Analysis of Immunoresistant Kidney Cancer
  Award Number: KCA-2024-TRAIL-003
  Sponsor: KIDNEY CANCER ASSOCIATION
  Hayes, M. (PD/PI)
• Title: Quantifying Spatial Properties of Immunosuppressive Macrophages in Papillary Renal Cell Carcinoma
  Award Number: HT9425-25-1-0310
  Sponsor: Department of Defense (DOD)
  Hayes, M. (PD/PI)
• Title: Defining the Role of YES1 in Modulating Immune Checkpoint Blockade Response in Clear Cell Renal Cell Carcinoma
  Award Number: KCA-2026-INTER-001
  Sponsor: KIDNEY CANCER ASSOCIATION
  Manley, B. (PD/PI), Hayes, M. (Co-PD/PI)