Noemi Andor, PhD

Dr. Andor's research combines computational biology, mathematical modeling and pharmacology to increase odds in the race against tumor evolution.

Associations

• Neuro-Oncology
• Gastrointestinal Oncology
• Integrated Mathematical Oncology
• Cancer Biology & Evolution Program

Education & Training

Graduate:

• Technical University, PhD - Bioinformatics
• Ludwig-Maximilians & Technical University, MSc - Bioinformatics

Fellowship:

• Stanford University -

Dr. Andor's research focuses on the development and integration of methods to quantify the clonal composition of a tumor from different perspectives, including its genome, transcriptome and appearance.  Overall goal is to use these clone characteristics to inform how a tumo's environment can be altered in order to favor certain tumor subclones over others.

• Beck R, Tagal V, Amin S, Bakhoum SF, Maley C, Verhaak RGW, Gomes AP, Andor N. Energetics of whole genome doubling and genomic instability. Cancer Lett. 2025 Oct.630:217878. Pubmedid: 40517938.
• Veith T, Beck R, Brown JS, Andor N. Inverse Game Theory Characterizes Frequency-Dependent Selection Driven by Karyotypic Diversity in Triple Negative Breast Cancer. bioRxiv. 2025 Mar. Pubmedid: 40196548. Pmcid: PMC11974723.
• Beck RJ, Andor N. Local Adaptive Mapping of Karyotype Fitness Landscapes. bioRxiv. 2025 Jun. Pubmedid: 40667108. Pmcid: PMC12262491.
• Veith T, Beck R, Tagal V, Li T, Alahmari S, Cole J, Hannaby D, Kyei J, Yu X, Maksin K, Schultz A, Lee H, El Naqa I, Eschrich S, Ji HP, Diaz A, Andor N. CLONEID: A Framework for Longitudinal Integration of Phenotypic and Genotypic Data to Monitor and Steer Subclonal Dynamics. bioRxiv. 2025 Jul. Pubmedid: 40631300. Pmcid: PMC12236826.
• Nowicka Z, Rentzeperis F, Tagal V, Teer JK, Ilter D, Beck RJ, Cole JP, Forero Pinto AM, Tejero JD, Scanu E, Veith T, Dominguez-Viqueira W, Maksin K, Carrillo-Perez FM, Gevaert O, Xu X, Karreth FA, Abdalah MA, Fiandaca G, Pasetto S, Prabhakaran S, Schultz A, Ojwang' AME, Barnholtz-Sloan JS, Farinhas JM, Gomes AP, Katira P, Andor N. Interactions between Ploidy and Resource Availability Shape Clonal Evolution in Glioblastoma. Cancer Res. 2025 Apr.85(8):1544-1559. Pubmedid: 39933186.
• Alahmari S, Schultz A, Albrecht J, Tagal V, Siddiqui Z, Prabhakaran S, El Naqa I, Anderson A, Heiser L, Andor N. Cell identity revealed by precise cell cycle state mapping links data modalities. bioRxiv. 2024 Sep. Pubmedid: 39282313. Pmcid: PMC11398313.
• Carrillo-Perez F, Cramer EM, Pizurica M, Andor N, Gevaert O. Towards Digital Quantification of Ploidy from Pan-Cancer Digital Pathology Slides using Deep Learning. bioRxiv. 2024 Aug. Pubmedid: 39229200. Pmcid: PMC11370345.
• Nowicka Z, Rentzeperis F, Beck R, Tagal V, Pinto AF, Scanu E, Veith T, Cole J, Ilter D, Viqueira WD, Teer JK, Maksin K, Pasetto S, Abdalah MA, Fiandaca G, Prabhakaran S, Schultz A, Ojwang M, Barnholtz-Sloan JS, Farinhas JM, Gomes AP, Katira P, Andor N. Interactions between ploidy and resource availability shape clonal interference at initiation and recurrence of glioblastoma. bioRxiv. 2023 Oct. Pubmedid: 37905142. Pmcid: PMC10614845.
• Gatenbee CD, Baker AM, Prabhakaran S, Swinyard O, Slebos RJC, Mandal G, Mulholland E, Andor N, Marusyk A, Leedham S, Conejo-Garcia JR, Chung CH, Robertson-Tessi M, Graham TA, Anderson ARA. Virtual alignment of pathology image series for multi-gigapixel whole slide images. Nat Commun. 2023 Jul.14(1):4502. Pubmedid: 37495577. Pmcid: PMC10372014.
• Veith T, Schultz A, Alahmari S, Beck R, Johnson J, Andor N. Mathematical Modeling of Clonal Interference by Density-Dependent Selection in Heterogeneous Cancer Cell Lines. Cells. 2023 Jul.12(14). Pubmedid: 37508513. Pmcid: PMC10378185.
• Kimmel GJ, Beck RJ, Yu X, Veith T, Bakhoum S, Altrock PM, Andor N. Intra-tumor heterogeneity, turnover rate and karyotype space shape susceptibility to missegregation-induced extinction. PLoS Comput Biol. 2023 Jan.19(1):e1010815. Pubmedid: 36689467. Pmcid: PMC9917311.
• Andor N, Altrock PM, Jain N, Gomes AP. Tipping Cancer Cells Over the Edge: The Context-Dependent Cost of High Ploidy. Cancer Res. 2022 Mar.82(5):741-748. Pubmedid: 34785577. Pmcid: PMC8898264.
• Su A, Lee H, Tan X, Suarez CJ, Andor N, Nguyen Q, Ji HP. A deep learning model for molecular label transfer that enables cancer cell identification from histopathology images. NPJ Precis Oncol. 2022 Mar.6(1):14. Pubmedid: 35236916. Pmcid: PMC8891271.
• Bukkuri A, Andor N, Darcy IK. Applications of Topological Data Analysis in Oncology. Front Artif Intell. 2021 Apr.4:659037. Pubmedid: 33928240. Pmcid: PMC8076640.
• Kimmel GJ, Dane M, Heiser LM, Altrock PM, Andor N. Integrating Mathematical Modeling with High-Throughput Imaging Explains How Polyploid Populations Behave in Nutrient-Sparse Environments. Cancer Res. 2020 Nov.80(22):5109-5120. Pubmedid: 32938640. Pmcid: PMC7671819.
• Andor N, Lau BT, Catalanotti C, Sathe A, Kubit M, Chen J, Blaj C, Cherry A, Bangs CD, Grimes SM, Suarez CJ, Ji HP. Joint single cell DNA-seq and RNA-seq of gastric cancer cell lines reveals rules of in vitro evolution. NAR Genom Bioinform. 2020 Jun.2(2):lqaa016. Pubmedid: 32215369. Pmcid: PMC7079336.
• Enderling H, Altrock PM, Andor N, Basanta D, Brown JS, Gatenby RA, Marusyk A, Rejniak KA, Silva A, Anderson ARA. High School Internship Program in Integrated Mathematical Oncology (HIP IMO): Five-Year Experience at Moffitt Cancer Center. Bull Math Biol. 2020 Jul.82(7):91. Pubmedid: 32648152.
• Chen J, Lau BT, Andor N, Grimes SM, Handy C, Wood-Bouwens C, Ji HP. Single-cell transcriptome analysis identifies distinct cell types and niche signaling in a primary gastric organoid model. Sci Rep. 2019 Mar.9(1):4536. Pubmedid: 30872643. Pmcid: PMC6418230.
• Andor N, Simonds EF, Czerwinski DK, Chen J, Grimes SM, Wood-Bouwens C, Zheng GXY, Kubit MA, Greer S, Weiss WA, Levy R, Ji HP. Single-cell RNA-Seq of follicular lymphoma reveals malignant B-cell types and coexpression of T-cell immune checkpoints. Blood. 2019 Mar.133(10):1119-1129. Pubmedid: 30591526. Pmcid: PMC6405336.
• Vences-Catalán F, Kuo CC, Rajapaksa R, Duault C, Andor N, Czerwinski DK, Levy R, Levy S. CD81 is a novel immunotherapeutic target for B cell lymphoma. J Exp Med. 2019 Jul.216(7):1497-1508. Pubmedid: 31123084. Pmcid: PMC6605745.
• Xia LC, Ai D, Lee H, Andor N, Li C, Zhang NR, Ji HP. SVEngine: an efficient and versatile simulator of genome structural variations with features of cancer clonal evolution. Gigascience. 2018 Jul.7(7). Pubmedid: 29982625. Pmcid: PMC6057526.
• Daynac M, Chouchane M, Collins HY, Murphy NE, Andor N, Niu J, Fancy SPJ, Stallcup WB, Petritsch CK. Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis. Nat Commun. 2018 Aug.9(1):2862. Pubmedid: 30131568. Pmcid: PMC6104045.
• Andor N, Maley CC, Ji HP. Genomic Instability in Cancer: Teetering on the Limit of Tolerance. Cancer Res. 2017 May.77(9):2179-2185. Pubmedid: 28432052. Pmcid: PMC5413432.
• Andor N, Graham TA, Jansen M, Xia LC, Aktipis CA, Petritsch C, Ji HP, Maley CC. Pan-cancer analysis of the extent and consequences of intratumor heterogeneity. Nat Med. 2016 Jan.22(1):105-113. Pubmedid: 26618723. Pmcid: PMC4830693.
• Andor N, Harness JV, Müller S, Mewes HW, Petritsch C. EXPANDS: expanding ploidy and allele frequency on nested subpopulations. Bioinformatics. 2014 Jan.30(1):50-60. Pubmedid: 24177718. Pmcid: PMC3866558.
• Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014 Dec.20(12):1394-1396. Pubmedid: 25401693. Pmcid: PMC4257862.
• Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell. 2011 Sep.20(3):328-340. Pubmedid: 21907924. Pmcid: PMC3297490.

• Title: A framework to integrate live-cell imaging with single-cell sequencing and learn how cells adapt to new environments
  Award Number: 5R03CA259873-02
  Sponsor: National Cancer Institute (NCI)
  Andor, N. (PD/PI)
• Title: Characterizing Cytotoxic Therapy Induced Shifts in the Cost-to-Benefit Ratio of High Ploidy
  Award Number: 5R37CA266727
  Sponsor: National Cancer Institute (NCI)
  Andor, N. (PD/PI)
• Title: Engineering Model-Based Systems to Monitor and Steer Subclonal Dynamics
  Award Number: 5R21CA269415-02
  Sponsor: National Cancer Institute (NCI)
  Andor, N. (PD/PI)
• Title: IMAT-ITCR Collaboration: Engineering model-based systems to monitor and steer subclonal dynamics
  Award Number: 3R21CA269415-02S1
  Sponsor: National Cancer Institute (NCI)
  Andor, N. (PD/PI)