Yu Zhu, PhD

Regulation of tumor immunity by the vascular endothelium

Associations

• Immunology

Our research is positioned at the interface of cancer immunology and vascular biology, with a central focus on how the vascular endothelium regulates cancer immune responses. Active areas of investigation include: (1) defining how endothelial cells sculpt the tumor microenvironment to control immune cell trafficking, (2) determining how cancer cells drive endothelial cell subset specialization to suppress lymphocyte recruitment, and (3) elucidating how endothelial cells in the draining lymph nodes regulate lymphocyte activation. Our ultimate goal is to uncover actionable mechanisms and develop effective vessel-targeting therapeutics to boost anti-tumor immunity.