Hongzhi Xu, MD, PhD

Dr. Xu received his MD degree from Tongji Medical University, Wuhan, China, and his PhD from University of North Carolina, Charlotte. He completed a Postdoctoral Research Fellowship in Biomedical Science, Massachusetts General Hospital, Harvard Medical School, and a Residency in Pathology at the Louisiana State University. He went on to complete a Genitourinary Pathology Fellowship at Tufts Medical Center and, most recently, a Fellowship in Cytopathology at Duke University Medical Center. Dr. Xu’s clinical interests include genitourinary pathology and cytopathology. His research interests include identifying diagnostic and prognostic markers in genitourinary tumors, as well as investigating the application of new technology to daily clinical practice in pathology.

Clinical Trial 22307
The Paris System-Based Machine Learning and Artificial Intelligence (AI) For Reporting Urine Cytology
Condition: Genitourinary
Status: Open

If you believe you are eligible for one of these trials or studies, please call
813-745-6100 or toll-free 1-800-679-0775.

• Fazili A, Jazayeri SB, Rose KM, Guske C, Wen L, Durant A, Prunty M, Bukavina L, Tyson MD, Grass GD, Xu H, Spiess PE, Gilbert SM, Sexton WJ, Zemp L, Pessoa RR, Poch M, Lerner SP, Li R. Cisplatin-ineligible patients with muscle-invasive bladder cancer demonstrate poor long-term survival following immediate radical cystectomy. BJU Int. 2025 Sep. Pubmedid: 40932312.
• Fazili A, Sirard RB, Elst L, Vandermaesen K, Xu H, Albersen M, Spiess PE. Novel Role Of DSNB in Staging of Primary Urethral Cancer: New Standard?. Int Braz J Urol. 2025 May.51(3). Pubmedid: 40079925. Pmcid: PMC12052031.
• Song X, Yu X, Moran-Segura CM, Xu H, Li T, Davis JT, Vosoughi A, Grass GD, Li R, Wang X. ROICellTrack: a deep learning framework for integrating cellular imaging modalities in subcellular spatial transcriptomic profiling of tumor tissues. Bioinformatics. 2025 May.41(5). Pubmedid: 40199763. Pmcid: PMC12085996.
• Guske C, Jazayeri SB, Harrs C, Rao N, Davaro F, Xu H, Zemp L, Yu A, Gilbert SM, Poch M, Spiess PE, Sexton W, Linscott J, Li R. Assessing the Impact of Treatment Timing Protocols in Clinical Trials for Bacillus Calmette-Guérin-unresponsive Non-muscle-invasive Bladder Cancer. Eur Urol Oncol. 2025 Aug.8(4):888-892. Pubmedid: 40670271.
• Liveringhouse C, Sim AJ, Zhang J, Jain RK, Naidu SU, Linkowski L, Zemp LW, Yu A, Sexton WJ, Spiess PE, Gilbert SM, Poch MA, Pow-Sang J, Li R, Manley BJ, Vosoughi A, Dhillon J, Xu H, Torres-Roca JF, Johnstone PAS, Yamoah K, Grass GD. A Single Institution Experience in the Management of Localized Neuroendocrine Carcinoma of the Bladder. Clin Genitourin Cancer. 2024 Dec.22(6):102222. Pubmedid: 39353214.
• Linscott JA, Miyagi H, Murthy PB, Yao S, Grass GD, Vosoughi A, Xu H, Wang X, Yu X, Yu A, Zemp L, Gilbert SM, Poch MA, Sexton WJ, Spiess PE, Li R. From Detection to Cure - Emerging Roles for Urinary Tumor DNA (utDNA) in Bladder Cancer. Curr Oncol Rep. 2024 Aug.26(8):945-958. Pubmedid: 38837106.
• Cockey SG, Xu H, Al-Jumayli M. Elevation of cancer antigen 15-3 owing to oncocytic renal neoplasm in a patient without evidence of breast cancer recurrence on follow-up: a case report. J Med Case Rep. 2023 Dec.17(1):526. Pubmedid: 38062521. Pmcid: PMC10701971.
• Xu H, Genega EM, Zhuang L, Zhou M. High-grade Urothelial Carcinoma with Malignant Melanocytic Differentiation. Int J Surg Pathol. 2021 Oct.29(7):794-797. Pubmedid: 33733892.
• Shi M, Xu H, Sangster GP, Gu X. Pulmonary Metastases from an Undifferentiated Embryonal Sarcoma of the Liver: A Case Report and Review. Case Rep Oncol Med. 2018 Sep.2018:7840865. Pubmedid: 30254779. Pmcid: PMC6142750.
• Herrera GA, Teng J, Zeng C, Xu H, Liang M, Alexander JS, Liu B, Boyer C, Turbat-Herrera EA. Phenotypic plasticity of mesenchymal stem cells is crucial for mesangial repair in a model of immunoglobulin light chain-associated mesangial damage. Ultrastruct Pathol. 2018 Oct.42(3):262-288. Pubmedid: 29668344.
• Shi M, Xu H, DiPoto Brahmbhatt A, Gonzalez-Toledo E, Georgescu MM. Hemorrhagic Brain Metastases in a Patient with Anaplastic Lymphoma Kinase (ALK)-Rearranged Invasive Mucinous Adenocarcinoma of the Lung. Am J Case Rep. 2018 Jan.19:99-104. Pubmedid: 29371584. Pmcid: PMC5796364.
• Xu H, Watson D, Yu YM, Traber DL, Fischer S, Nichols J, Deyo D, Traber LL, Cortiella J. Isotopic study of L-Arginine kinetics in the lung during pseudomonas sepsis in an ovine model. Int J Burns Trauma. 2014 Feb.4(1):31-39. Pubmedid: 24624312. Pmcid: PMC3945826.
• Xu H, Watson D, Yu YM, Traber DL, Fischer S, Nichols J, Deyo D, Traber LL, Cortiella J. Isotopic study of L-Arginine kinetics in the lung during pseudomonas sepsis in an ovine model. Int J Burns Trauma. 2013 Nov.3(4):201-208. Pubmedid: 24273695. Pmcid: PMC3828740.
• Xu H, Yu YM, Ma H, Carter EA, Fagan S, Tompkins RG, Fischman AJ. Glucose metabolism during the early "flow phase" after burn injury. J Surg Res. 2013 Jan.179(1):e83-e90. Pubmedid: 22459295. Pmcid: PMC4074901.
• Liu Q, Izamis ML, Xu H, Berendsen T, Yarmush M, Uygun K. Strategies to rescue steatotic livers before transplantation in clinical and experimental studies. World J Gastroenterol. 2013 Aug.19(29):4638-4650. Pubmedid: 23922462. Pmcid: PMC3732837.
• Xu H, Berendsen T, Kim K, Soto-Gutiérrez A, Bertheium F, Yarmush ML, Hertl M. Excorporeal normothermic machine perfusion resuscitates pig DCD livers with extended warm ischemia. J Surg Res. 2012 Apr.173(2):e83-e88. Pubmedid: 22099594. Pmcid: PMC3682784.
• Berendsen TA, Izamis ML, Xu H, Liu Q, Hertl M, Berthiaume F, Yarmush ML, Uygun K. Hepatocyte viability and adenosine triphosphate content decrease linearly over time during conventional cold storage of rat liver grafts. Transplant P. 2011 Jun.43(5):1484-1488. Pubmedid: 21693222. Pmcid: PMC3121302.
• Nagrath D, Xu H, Tanimura Y, Zuo R, Berthiaume F, Avila M, Yarmush R, Yarmush ML. Metabolic preconditioning of donor organs: defatting fatty livers by normothermic perfusion ex vivo. Metab Eng. 2009 Nov.11(4-5):274-283. Pubmedid: 19508897. Pmcid: PMC2814076.
• Xu H, Lee CY, Clemens MG, Zhang JX. Inhibition of TXA synthesis with OKY-046 improves liver preservation by prolonged hypothermic machine perfusion in rats. J Gastroenterol Hepatol. 2008 Jul.23(7 Pt 2):e212-e220. Pubmedid: 17645480.
• Karaa A, Kamoun WS, Xu H, Zhang J, Clemens MG. Differential effects of oxidative stress on hepatic endothelial and Kupffer cell eicosanoid release in response to endothelin-1. Microcirculation. 2006 Sep.13(6):457-466. Pubmedid: 16864412.
• Jain S, Lee CY, Baicu S, Duncan H, Xu H, Jones JW, Clemens MG, Brassil J, Taylor MJ, Brockbank KG. Hepatic function in hypothermically stored porcine livers: comparison of hypothermic machine perfusion vs cold storage. Transplant P. 2005 Jan.37(1):340-341. Pubmedid: 15808637.
• Xu H, Zhang JX, Jones JW, Southard JH, Clemens MG, Lee CY. Hypothermic machine perfusion of rat livers preserves endothelial cell function. Transplant P. 2005 Jan.37(1):335-337. Pubmedid: 15808635.
• Xu H, Korneszczuk K, Karaa A, Lin T, Clemens MG, Zhang JX. Thromboxane A2 from Kupffer cells contributes to the hyperresponsiveness of hepatic portal circulation to endothelin-1 in endotoxemic rats. Am J Physiol Gastrointest Liver Physiol. 2005 Feb.288(2):G277-G283. Pubmedid: 15647606.
• Xu H, Lee CY, Clemens MG, Zhang JX. Pronlonged hypothermic machine perfusion preserves hepatocellular function but potentiates endothelial cell dysfunction in rat livers. Transplantation. 2004 Jun.77(11):1676-1682. Pubmedid: 15201666.
• Jain S, Xu H, Duncan H, Jones JW, Zhang JX, Clemens MG, Lee CY. Ex-vivo study of flow dynamics and endothelial cell structure during extended hypothermic machine perfusion preservation of livers. Cryobiology. 2004 Jun.48(3):322-332. Pubmedid: 15157780.
• Yokoyama Y, Xu H, Kresge N, Keller S, Sarmadi AH, Baveja R, Clemens MG, Zhang JX. Role of thromboxane A2 in early BDL-induced portal hypertension. Am J Physiol Gastrointest Liver Physiol. 2003 Mar.284(3):G453-G460. Pubmedid: 12431905.