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25 Clinical Trials Found

Clinical Trial 23647

A Phase 1/2, Open-label, Global, Multicenter, Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of PYX-201 in Combination with Pembrolizumab in Participants with Advanced Solid Tumors
Disease Site: Larynx, Lip, Oral Cavity and Pharynx
PI: Park, Robin

Clinical Trial 23777

A Randomized, Masked, Placebo Controlled, Phase II Trial of Concurrent Chemoradiation with BMX-001 in Patients with Head and Neck Squamous Cell Carcinoma Receiving Concurrent Chemoradiation
Disease Site: Larynx, Lip, Oral Cavity and Pharynx
PI: Razavian, Niema

Clinical Trial 21131

A Phase II Randomized Trial of Adjuvant Therapy with Pembrolizumab After Resection of Recurrent/Second Primary Head and Neck Squamous Cell Carcinoma with High Risk Features
Disease Site: Larynx, Lip, Oral Cavity and Pharynx, Head & Neck
PI: Kirtane, Kedar

Clinical Trial 23376

Disease Site: Larynx, Lip, Oral Cavity and Pharynx
PI: Kirtane, Kedar

Clinical Trial 23229

An Open-Label Phase 1/2a Clinical Trial to Evaluate the Safety, Immunogenicity, and Preliminary Efficacy of a Lentiviral Vector-Based Therapeutic Vaccine Against Human Papilloma Virus (Lenti-HPV-07) in Participants with HPV-Associated Oropharyngeal Squamous Cell Cancer or Cervical Cancer
Disease Site: Cervix, Head & Neck, Lip, Oral Cavity and Pharynx, Oropharynx
PI: Rabinowits, Guilherme

Clinical Trial 23697

A Phase 1/1b, Open-label, Multicenter, First-in-human Dose Escalation and Dose Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Anti-tumor Activity of VVD-159642, a RAS-PI3KA Inhibitor, as a Single Agent and in Combination in Participants With Advanced Solid Tumors
Disease Site: Any Site, Breast, Cervix, Corpus Uteri, Esophagus, Lip, Oral Cavity and Pharynx, Lung, Melanoma, skin, Other Digestive Organ, Other Female Genital, Other Skin, Ovary, Pancreas, Prostate, Small Intestine, Stomach
PI: Haura, Eric

Clinical Trial 23766

A First-in-Human Phase 1 Dose Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of FID-022 as Monotherapy in Patients with Advanced Solid Tumors
Disease Site: Anus, Any Site, Breast, Colon, Esophagus, Larynx, Lip, Oral Cavity and Pharynx, Lung, Rectum, Small Intestine, Soft Tissue, Stomach
PI: Rabinowits, Guilherme

Clinical Trial 23298

A Phase 2/3, Randomized, Double-Blind, Controlled Study of Zanzalintinib (XL092) in Combination with Pembrolizumab Vs Pembrolizumab in the First-Line Treatment Of Subjects with PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Disease Site: Head & Neck, Larynx, Lip, Oral Cavity and Pharynx, Squamous Cell Carcinoma (SCC)
PI: Rabinowits, Guilherme

Clinical Trial 23204

Disease Site: Larynx, Lip, Oral Cavity and Pharynx
PI: Chung, Christine

Clinical Trial 23441

Phase 1/1b Study of AKT Inhibitor Ipatasertib with Chemoradiation for Locally Advanced Head and Neck Cancer
Disease Site: Larynx, Lip, Oral Cavity and Pharynx
PI: Yang, George

Clinical Trial 20490

Keystroke: A Randomized Phase II Study of Pembrolizumab (Keytruda) Plus Stereotactic Re-irradiation versus SBRT Alone For Locoregionally Recurrent or Second Primary Head and Neck Carcinoma
Disease Site: Other Skin, Lip, Oral Cavity and Pharynx
PI: Caudell, Jimmy

Clinical Trial 23691

A Multicenter, Randomized, Double-blind, Phase 2/3 Study of Ficerafusp Alfa (BCA101) or Placebo in Combination with Pembrolizumab for First-Line Treatment of PD-L1-positive, Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Disease Site: Larynx, Lip, Oral Cavity and Pharynx
PI: Chung, Christine