
Biopsied tissue is analyzed by a pathologist to determine if cancer cells are present and to identify the cancer type and its genetic makeup.
When faced with the possibility of cancer, every decision matters. A biopsy — a procedure where a small tissue sample is removed and examined under a microscope — is one of the most critical steps in determining whether cancer is present. Even if there's only a small percentage chance something could be cancer, the steps that were taken at the very beginning can be crucial to your outcome if you end up in that small percentage.
Choosing a specialist for this procedure can make all the difference, even if cancer isn’t confirmed. Here’s why starting with a cancer specialist like those at Moffitt Cancer Center is your best option.

Biopsied tissue is analyzed by a pathologist to determine if cancer cells are present and to identify the cancer type and its genetic makeup.
The reality is that most tumors, masses and nodules are benign. Seeking the advice of a cancer expert prior to getting a potentially invasive biopsy can help you make a decision that's best for your health.
Moffitt is able to perform biopsies on most tumors, masses and nodules. For suspicious moles or bumps on the skin, you should see your primary care or dermatologist for testing. For lumps larger than a golf ball, you can call Moffitt for an appointment with a specialist.
Sometimes a cancer expert will recommend that a condition be closely monitored rather than biopsied for the safety of the patient.
For example, Moffitt has a Lung Nodule Clinic that evaluates any lung nodule found on imaging and will refer patients to the Lung Nodule Surveillance Clinic or to a thoracic surgeon depending on the outcome of that lung nodule review.
If there's ever a chance that a mass could be cancer, no matter how small, you should seek the expertise of an oncology specialist. They will approach the procedure as though it is cancer taking all the steps that would lead to the best possible outcome.
At a specialty cancer center like Moffitt, biopsies are conducted with unmatched precision by specialists who dedicate their careers to diagnosing and treating cancer. This expertise means they understand the genetic makeup of different types of tumors and can spot subtle variations that general practitioners might miss.
Backing these patient-facing specialists is a team of highly skilled pathologists who analyze biopsy samples with advanced molecular diagnostics. This leading-edge technology helps uncover critical details about the tissue, such as genetic mutations, which could influence progression and treatment options. Moffitt’s comprehensive approach ensures you receive the most accurate and thorough diagnosis possible.
It varies by cancer type but here are estimates for some of the most commonly biopsied areas:
Biopsies need to be performed with care to avoid the risk of tumor “spill”, which is when cancer cells spread during the procedure. Cancer specialists are trained to use advanced techniques that minimize this risk, ensuring that your health is protected throughout the process.
By choosing a cancer center like Moffitt, you can trust that your procedure is in the hands of experts who are meticulous in preventing complications.
Biopsies don’t have to be a stressful or uncomfortable experience. Cancer specialists will utilize the most minimally invasive techniques available to make the process as smooth as possible. These advanced methods, such as image-guided needle biopsies, not only reduce discomfort but improve accuracy and also speed up recovery times.
Though not possible in every case, minimally invasive approaches are safer, more precise, and better for overall patient outcomes. You deserve a biopsy experience that prioritizes your comfort without compromising accuracy.
Accuracy Through Advanced Imaging and Genetic Testing
A biopsy is only as good as its accuracy. Moffitt's cancer specialists use state-of-the-art imaging technology, like CT scans and MRIs, to guide the biopsy needle directly to the suspicious area. This precision ensures the sample taken is from the correct location, reducing the chances of inconclusive results.
Moffitt’s team doesn’t stop at just analyzing the tissue. Advanced genetic testing may be performed to uncover any underlying mutations or markers that might inform your treatment. This level of detail ensures that you get a clear and actionable diagnosis from the very start.
Adequate Sample Size
One of the most common issues with biopsies performed outside specialized centers is insufficient sample size. Without enough tissue, pathologists may struggle to deliver a conclusive diagnosis, leading to delays and additional procedures.
Moffitt’s specialists are trained to collect ample tissue during the first procedure, ensuring pathologists have everything they need for a complete analysis. This not only saves you time but also provides peace of mind knowing that you’re on the fastest path to answers.
At Moffitt Cancer Center, we believe every patient deserves the most accurate and comprehensive diagnosis — the first time. Our outcomes are four times the national average because we combine unparalleled expertise, advanced technology, and a team dedicated to precision and care.
If you’re facing the possibility of cancer or need a biopsy for any tumor, mass, nodule, or precancerous cell, trust the experts at Moffitt Cancer Center. Schedule your consultation today and start with the team that gets it right.
Contact us today to schedule an appointment. Call us at 1-888-663-3488 or request an appointment online.