Yangsheng Zhou, DO, PhD

Cancer Focus:
Anal Cancer, Bladder Cancer, Cholangiocarcinoma (Bile Duct Cancer), Colon Cancer, Colorectal Cancer, Esophageal Cancer, Gallbladder Cancer, Kidney (Renal Cell) Cancer, Liver (Hepatocellular) Cancer, Pancreatic Cancer, Prostate Cancer, Stomach (Gastric) Cancer

Dr. Zhou is a medical oncologist at Moffitt Cancer Center who specializes in the treatment of gastrointestinal and genitourinary malignancies.

He is committed to providing innovative, patient-centered care through individualized treatment plans and the use of advanced therapies, including chemotherapy, targeted therapy and immunotherapy.

Before joining Moffitt, Dr. Zhou earned his Doctor of Osteopathic Medicine degree from the New York Institute of Technology College of Osteopathic Medicine in Old Westbury, New York. He also received a Ph.D. in Biomedical Sciences from the State University of New York at Albany. He completed a postdoctoral research fellowship in the Department of Medical Oncology at the Dana-Farber Cancer Institute and Harvard Medical School in Boston, Massachusetts.

• Zhao JJ, Chu ZB, Hu Y, Lin J, Wang Z, Jiang M, Chen M, Wang X, Kang Y, Zhou Y, Ní Chonghaile T, Johncilla ME, Tai YT, Cheng JQ, Letai A, Munshi NC, Anderson KC, Carrasco RD. Targeting the miR-221-222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma. Cancer Res. 2015 Oct.75(20):4384-4397. Pubmedid: 26249174. Pmcid: PMC4609291.
• Zhou Y, Liu X, Xu L, Hunter ZR, Cao Y, Yang G, Carrasco R, Treon SP. Transcriptional repression of plasma cell differentiation is orchestrated by aberrant over-expression of the ETS factor SPIB in Waldenström macroglobulinaemia. Brit J Haematol. 2014 Sep.166(5):677-689. Pubmedid: 24801987.
• Hunter ZR, Xu L, Yang G, Zhou Y, Liu X, Cao Y, Manning RJ, Tripsas C, Patterson CJ, Sheehy P, Treon SP. The genomic landscape of Waldenstrom macroglobulinemia is characterized by highly recurring MYD88 and WHIM-like CXCR4 mutations, and small somatic deletions associated with B-cell lymphomagenesis. Blood. 2014 Mar.123(11):1637-1646. Pubmedid: 24366360.
• Xu L, Hunter ZR, Yang G, Zhou Y, Cao Y, Liu X, Morra E, Trojani A, Greco A, Arcaini L, Varettoni M, Brown JR, Tai YT, Anderson KC, Munshi NC, Patterson CJ, Manning RJ, Tripsas CK, Lindeman NI, Treon SP. MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction. Blood. 2013 Mar.121(11):2051-2058. Pubmedid: 23321251. Pmcid: PMC3596964.
• Yang G, Zhou Y, Liu X, Xu L, Cao Y, Manning RJ, Patterson CJ, Buhrlage SJ, Gray N, Tai YT, Anderson KC, Hunter ZR, Treon SP. A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenström macroglobulinemia. Blood. 2013 Aug.122(7):1222-1232. Pubmedid: 23836557.
• Treon SP, Xu L, Yang G, Zhou Y, Liu X, Cao Y, Sheehy P, Manning RJ, Patterson CJ, Tripsas C, Arcaini L, Pinkus GS, Rodig SJ, Sohani AR, Harris NL, Laramie JM, Skifter DA, Lincoln SE, Hunter ZR. MYD88 L265P somatic mutation in Waldenström's macroglobulinemia. N Engl J Med. 2012 Aug.367(9):826-833. Pubmedid: 22931316.
• Zhou Y, Liu X, Xu L, Tseng H, Cao Y, Jiang J, Ciccarelli BT, Yang G, Patterson CJ, Hunter ZR, Treon SP. Matrix metalloproteinase-8 is overexpressed in Waldenström's macroglobulinemia cells, and specific inhibition of this metalloproteinase blocks release of soluble CD27. Clin Lymphoma Myeloma Leuk. 2011 Feb.11(1):172-175. Pubmedid: 21856553.
• Ebel GD, Fitzpatrick KA, Lim PY, Bennett CJ, Deardorff ER, Jerzak GV, Kramer LD, Zhou Y, Shi PY, Bernard KA. Nonconsensus West Nile virus genomes arising during mosquito infection suppress pathogenesis and modulate virus fitness in vivo. J Virol. 2011 Dec.85(23):12605-12613. Pubmedid: 21937657. Pmcid: PMC3209405.
• Hunter ZR, Manning RJ, Hanzis C, Ciccarelli BT, Ioakimidis L, Patterson CJ, Lewicki MC, Tseng H, Gong P, Liu X, Zhou Y, Yang G, Sun J, Xu L, Sheehy P, Morra M, Treon SP. IgA and IgG hypogammaglobulinemia in Waldenström's macroglobulinemia. Haematologica. 2010 Mar.95(3):470-475. Pubmedid: 19903677. Pmcid: PMC2833078.
• Dong H, Ren S, Zhang B, Zhou Y, Puig-Basagoiti F, Li H, Shi PY. West Nile virus methyltransferase catalyzes two methylations of the viral RNA cap through a substrate-repositioning mechanism. J Virol. 2008 May.82(9):4295-4307. Pubmedid: 18305027. Pmcid: PMC2293060.
• Zhang B, Dong H, Zhou Y, Shi PY. Genetic interactions among the West Nile virus methyltransferase, the RNA-dependent RNA polymerase, and the 5' stem-loop of genomic RNA. J Virol. 2008 Jul.82(14):7047-7058. Pubmedid: 18448528. Pmcid: PMC2446981.
• Ciota AT, Ngo KA, Lovelace AO, Payne AF, Zhou Y, Shi PY, Kramer LD. Role of the mutant spectrum in adaptation and replication of West Nile virus. J Gen Virol. 2007 Mar.88(Pt 3):865-874. Pubmedid: 17325359. Pmcid: PMC3249657.
• Puig-Basagoiti F, Tilgner M, Bennett CJ, Zhou Y, Muñoz-Jordán JL, García-Sastre A, Bernard KA, Shi PY. A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis. Virology. 2007 Apr.361(1):229-241. Pubmedid: 17178141. Pmcid: PMC1952232.
• Zhou Y, Ray D, Zhao Y, Dong H, Ren S, Li Z, Guo Y, Bernard KA, Shi PY, Li H. Structure and function of flavivirus NS5 methyltransferase. J Virol. 2007 Apr.81(8):3891-3903. Pubmedid: 17267492. Pmcid: PMC1866096.
• Ray D, Shah A, Tilgner M, Guo Y, Zhao Y, Dong H, Deas TS, Zhou Y, Li H, Shi PY. West Nile virus 5'-cap structure is formed by sequential guanine N-7 and ribose 2'-O methylations by nonstructural protein 5. J Virol. 2006 Sep.80(17):8362-8370. Pubmedid: 16912287. Pmcid: PMC1563844.