Ariosto <span>S.</span> Silva, PhD
Researcher

Ariosto S. Silva, PhD

Academic Rank: Assistant Member

Overview

Discipline

    • Cancer Imaging and Metabolism
    • Cancer Biology and Evolution Program
    • Myeloma
    • Cancer Imaging and Technology

Education & Training

    • Universidade Estadual Campinas- Unicamp, Brazil, PhD - Genetics and Molecular Biology
    • Moffitt Cancer Center, Postdoctoral Fellow
Research

Evolution of tumor invasiveness and adaptive tumor microenvironment particularly in multiple myeloma; cancer metabolism

Publications

  • Maley CC, Aktipis A, Graham TA, Sottoriva A, Boddy AM, Janiszewska M, Silva AS, Gerlinger M, Yuan Y, Pienta KJ, Anderson KS, Gatenby R, Swanton C, Posada D, Wu CI, Schiffman JD, Hwang ES, Polyak K, Anderson ARA, Brown JS, Greaves M, Shibata D. Classifying the evolutionary and ecological features of neoplasms. Nat Rev Cancer. 2017 Sep. Pubmedid: 28912577.
  • Silva AS, Silva MC, Sudalagunta P, Distler AI, Jacobson T, Collins A, Nguyen T, Song J, Chen DT, Chen L, Cubitt CL, Baz R, Perez L, Rebatchouk D, Dalton W, Greene J, Gatenby RA, Gillies RJ, Sontag E, Meads MB, Shain K. An Ex Vivo Platform for the Prediction of Clinical Response in Multiple Myeloma. Cancer Res. 2017 Jun;77(12):3336-3351. Pubmedid: 28400475.
  • Emmons MF, Anreddy N, Cuevas J, Steinberger K, Yang S, McLaughlin M, Silva A, Hazlehurst LA. MTI-101 treatment inducing activation of Stim1 and TRPC1 expression is a determinant of response in multiple myeloma. Sci Rep. 2017 Jun;7(1):2685. Pubmedid: 28578393. Pmcid: PMC5457439.
  • Zhao X, Lwin T, Silva A, Shah B, Tao J, Fang B, Zhang L, Fu K, Bi C, Li J, Jiang H, Meads MB, Jacobson T, Silva M, Distler A, Darville L, Zhang L, Han Y, Rebatchouk D, Di Liberto M, Moscinski LC, Koomen JM, Dalton WS, Shain KH, Wang M, Sotomayor E, Tao J. Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma. Nat Commun. 2017 Apr;8:14920. Pubmedid: 28416797. Pmcid: PMC5399304.
  • Enriquez-Navas PM, Kam Y, Das T, Hassan S, Silva A, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA. Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer. Sci Transl Med. 2016 Feb;8(327):327ra24. Pubmedid: 26912903. Pmcid: PMC4962860.
  • Silva A, Jacobson T, Meads M, Distler A, Shain K. An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells. J Vis Exp. 2015 Jul;(101):e53070. Pubmedid: 26274375. Pmcid: PMC4544963.
  • Petersen PA, Silva AS, Gonçalves MB, Lapolli AL, Ferreira AM, Carbonari AW, Petrilli HM. Cd hyperfine interactions in DNA bases and DNA of mouse strains infected with Trypanosoma cruzi investigated by perturbed angular correlation spectroscopy and ab initio calculations. Biochemistry-Us. 2014 Jun;53(21):3446-3456. Pubmedid: 24801145.
  • Khin ZP, Ribeiro ML, Jacobson T, Hazlehurst L, Perez L, Baz R, Shain K, Silva AS. A preclinical assay for chemosensitivity in multiple myeloma. Cancer Res. 2014 Jan;74(1):56-67. Pubmedid: 24310398. Pmcid: PMC3915502.
  • Carvalho MG, Tsuneto LT, Moita Neto JM, Sousa LC, Sales Filho HL, Macêdo MB, Barroso JR, Pereira EM, Araújo AS, Silva AS, Monte SJ. HLA-A, HLA-B and HLA-DRB1 haplotype frequencies in Piauí's volunteer bone marrow donors enrolled at the Brazilian registry. Hum Immunol. 2013 Dec;74(12):1598-1602. Pubmedid: 23994585.
  • Tafreshi NK, Silva A, Estrella VC, McCardle TW, Chen T, Jeune-Smith Y, Lloyd MC, Enkemann SA, Smalley KS, Sondak VK, Vagner J, Morse DL. In vivo and in silico pharmacokinetics and biodistribution of a melanocortin receptor 1 targeted agent in preclinical models of melanoma. Mol Pharm. 2013 Aug;10(8):3175-3185. Pubmedid: 23763620. Pmcid: PMC3785103.
  • Silva AS, Kam Y, Khin ZP, Minton SE, Gillies RJ, Gatenby RA. Evolutionary approaches to prolong progression-free survival in breast cancer. Cancer Res. 2012 Dec;72(24):6362-6370. Pubmedid: 23066036. Pmcid: PMC3525750.
  • Ribeiro MdLC, Silva AS, Bailey KM, Kumar NB, Sellers TA, Gatenby RA, Arig IH, Gillies RJ. Buffer Therapy for Cancer. J Nutr Food Sci. 2012 Aug;2:6. Pubmedid: 24371544. Pmcid: PMC3872072.
  • Lee HO, Silva AS, Concilio S, Li YS, Slifker M, Gatenby RA, Cheng JD. Evolution of tumor invasiveness: the adaptive tumor microenvironment landscape model. Cancer Res. 2011 Oct;71(20):6327-6337. Pubmedid: 21859828. Pmcid: PMC3197231.
  • Silva AS, Gatenby RA. Adaptation to survival in germinal center is the initial step in onset of indolent stage of multiple myeloma. Mol Pharm. 2011 Dec;8(6):2012-2020. Pubmedid: 21958215. Pmcid: PMC3437606.
  • Silva A, Anderson AR, Gatenby R. A multiscale model of the bone marrow and hematopoiesis. Math Biosci Eng. 2011 Apr;8(2):643-658. Pubmedid: 21631151. Pmcid: PMC3754791.
  • Silva AS, Gatenby RA. A theoretical quantitative model for evolution of cancer chemotherapy resistance. Biol Direct. 2010 Jul;5:25. Pubmedid: 20406443. Pmcid: PMC2868834.
  • Silva AS, Gatenby RA, Gillies RJ, Yunes JA. A quantitative theoretical model for the development of malignancy in ductal carcinoma in situ. J Theor Biol. 2010 Feb;262(4):601-613. Pubmedid: 19887072.
  • Assumpção JG, Ganazza MA, de Araújo M, Silva AS, Scrideli CA, Brandalise SR, Yunes JA. Detection of clonal immunoglobulin and T-cell receptor gene rearrangements in childhood acute lymphoblastic leukemia using a low-cost PCR strategy. Pediatr Blood Cancer. 2010 Dec;55(7):1278-1286. Pubmedid: 20730889.
  • Silva AS, Yunes JA, Gillies RJ, Gatenby RA. The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res. 2009 Mar;69(6):2677-2684. Pubmedid: 19276380. Pmcid: PMC3718046.
  • Gatenby RA, Silva AS, Gillies RJ, Frieden BR. Adaptive therapy. Cancer Res. 2009 Jun;69(11):4894-4903. Pubmedid: 19487300. Pmcid: PMC3728826.
  • Silva AS, Yunes JA. Conservation of glycolytic oscillations in Saccharomyces cerevisiae and human pancreatic beta-cells: a study of metabolic robustness. Genet Mol Res. 2007 Apr;5(3):525-535. Pubmedid: 17117368.
  • Rodrigues AS, Matos CB, Silva F, Fonseca I, Nogueira C, Santos J, Silva AS, Cabrita A. Long-term peritoneal dialysis experience in Portugal. Int J Artif Organs. 2006 Dec;29(12):1109-1116. Pubmedid: 17219350.