Marcelo Bonini, PhD

Breast cancer metabolism and metastasis, Epigenetics, Histones, Histone Oxidation, Redox Biology.

Associations

• Metabolism and Physiology
• Cancer Biology & Evolution Program

Our lab is interested in the mechanisms connecting the decline of the energetic metabolism that occurs during aging with aging-related diseases being cancer a prime example. We focus on how a switch in the functioning of mitochondria to promote reactive oxygen species production over ATP changes the biophysical microenvironment of the cell with particular emphasis in the nucleus. We also aim at determining how these metabolic changes impact chromatin structure and gene expression. Our hypothesis is that reactive metabolites including, but not limited to reactive oxygen species, chemically modify chromatin components that provide it with specific structural patterns. These include histones, lamins, lncRNA and DNA itself. Since chromatin structure regulates gene accessibility and transcription efficiency our work postulates that changes in metabolism establish the biophysical environment where transcription happens. With that in mind we aim at developing therapeutic strategies to mitigate the effects of these metabolites on chromatin (chromatin protective agents) to improve cancer clinical care.

Clinical Trial 50521
Integrated Plasma Metabolomic and Cytokine Profiling to Characterize Cancer Cachexia
Condition: Thoracic
Status: Open

If you believe you are eligible for one of these trials or studies, please call
813-745-6100 or toll-free 1-800-679-0775.

• Tiek D, Song X, Wu R, Yu X, Walker M, Mao Y, Sisbarro D, He Q, Magassa A, Singh A, Lu J, Sharma AK, Miska J, Hu B, Bonini MG, Zhang X, Cheng SY. Cysteine addiction in drug resistant glioblastoma and therapeutic targeting with designer selenium compounds. Neurooncol. 2026 Mar.28(3):613-625. Pubmedid: 41212520. Pmcid: PMC13070503.
• Kim HH, Zhang EY, Palma FR, Kant A, Martinez-Sarmiento JA, Guo Z, Mauck RL, Shenoy V, Bonini MG, Heo SC, Lakadamyali M. O-SNAP uncovers nanoscale chromatin remodeling in dedifferentiation and stress responses. Nat Commun. 2026 Jun.17(1). Pubmedid: 42236704. Pmcid: PMC13396410.
• Dhahri H, Lau KH, Saintilnord WN, Lopes E, Damico HN, Hegazy YA, Palma FR, Melters DP, Chandler DP, Dalal Y, Licht JD, Bonini MG, Fondufe-Mittendorf YN. Single amino-acid differences define H2B variants and modify chromatin accessibility to induce EMT in breast cancer. Oncogene. 2026 Feb.45(6):669-689. Pubmedid: 41580505. Pmcid: PMC12867764.
• Shannon N, Raymond C, Palmer C, Homa S, Bonini M, Seward D, Cunniff B. Miro1 expression alters global gene expression, ERK1/2 phosphorylation, oxidation and cell cycle progression. J Cell Sci. 2025 May.138(9). Pubmedid: 40067243. Pmcid: PMC11993262.
• Eduardo MB, Cottone G, McCloskey CW, Liu S, Palma FR, Zappia MP, Islam ABMMK, Gao P, Setya J, Dennis S, Gao H, Zhang Q, Xuei X, Luo Y, Locasale J, Bonini MG, Khokha R, Frolov MV, Benevolenskaya EV, Chandel NS, Khan SA, Clare SE. A metabolic shift to the serine pathway induced by lipids fosters epigenetic reprogramming in nontransformed breast cells. Sci Adv. 2025 Mar.11(12):eads9182. Pubmedid: 40117373. Pmcid: PMC11927636.
• Lamperis SM, McMahon KM, Calvert AE, Rink JS, Vasan K, Pandkar MR, Crentsil EU, Chalmers ZR, McDonald NR, Kosmala CJ, Bonini MG, Matei D, Gordon LI, Chandel NS, Thaxton CS. CRISPR screen reveals a simultaneous targeted mechanism to reduce cancer cell selenium and increase lipid oxidation to induce ferroptosis. Proc Natl Acad Sci U S A. 2025 Jun.122(22):e2502876122. Pubmedid: 40445760. Pmcid: PMC12146712.
• Kim HH, Martinez-Sarmiento JA, Palma FR, Kant A, Zhang EY, Guo Z, Mauck RL, Heo SC, Shenoy V, Bonini MG, Lakadamyali M. O-SNAP: A comprehensive pipeline for spatial profiling of chromatin architecture. bioRxiv. 2025 Jul. Pubmedid: 40777470. Pmcid: PMC12330546.
• Gantner BN, Palma FR, Kayzuka C, Lacchini R, Foltz DR, Backman V, Kelleher N, Shilatifard A, Bonini MG. Histone oxidation as a new mechanism of metabolic control over gene expression. Trends Genet. 2024 Sep.40(9):739-746. Pubmedid: 38910033. Pmcid: PMC11387142.
• Gantner BN, Palma FR, Pandkar MR, Sakiyama MJ, Arango D, DeNicola GM, Gomes AP, Bonini MG. Metabolism and epigenetics: drivers of tumor cell plasticity and treatment outcomes. Trends Cancer. 2024 Nov.10(11):992-1008. Pubmedid: 39277448.
• Palma FR, Coelho DR, Pulakanti K, Sakiyama MJ, Huang Y, Ogata FT, Danes JM, Meyer A, Furdui CM, Spitz DR, Gomes AP, Gantner BN, Rao S, Backman V, Bonini MG. Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance. Cell Rep. 2024 Mar.43(3):113897. Pubmedid: 38493478. Pmcid: PMC11209755.
• Palma FR, Coelho DR, Pulakanti K, Sakiyama MJ, Huang Y, Ogata FT, Danes JM, Meyer A, Furdui CM, Spitz DR, Gomes AP, Gantner BN, Rao S, Backman V, Bonini MG. Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance. Cell Rep. 2024 Jul.43(7):114415. Pubmedid: 38923462. Pmcid: PMC11560056.
• Palma FR, Gantner BN, Sakiyama MJ, Kayzuka C, Shukla S, Lacchini R, Cunniff B, Bonini MG. ROS production by mitochondria: function or dysfunction?. Oncogene. 2024 Jan.43(5):295-303. Pubmedid: 38081963.
• Morrell MA, Willis TR, Brown DR, O'Brian CA, Post SL, Woloschak GE, Bonini MG, Paunesku T, Popovic J, Manning TM, Henley C, Girotti J, Rogers R, Velásquez C, López J, Glenn J, Simon MA. Lessons learned in the practice of community-based participatory research with community partner collaboration in study design and implementation: the community scientist model. Cancer Causes Control. 2023 Jul.34(7):621-624. Pubmedid: 37081154. Pmcid: PMC10259190.
• Coelho DR, Palma FR, Paviani V, LaFond KM, Huang Y, Wang D, Wray B, Rao S, Yue F, Bonini MG, Gantner BN. SOCS1 regulates a subset of NFκB-target genes through direct chromatin binding and defines macrophage functional phenotypes. iScience. 2023 Apr.26(4):106442. Pubmedid: 37020964. Pmcid: PMC10068561.
• Jiang Y, Krantz S, Qin X, Li S, Gunasekara H, Kim YM, Zimnicka A, Bae M, Ma K, Toth PT, Hu Y, Shajahan-Haq AN, Patel HH, Gentile S, Bonini MG, Rehman J, Liu Y, Minshall RD. Caveolin-1 controls mitochondrial damage and ROS production by regulating fission - fusion dynamics and mitophagy. Redox Biol. 2022 Jun.52:102304. Pubmedid: 35413643. Pmcid: PMC9018165.
• Coelho DR, Palma FR, Paviani V, He C, Danes JM, Huang Y, Calado JCP, Hart PC, Furdui CM, Poole LB, Schipma MJ, Bonini MG. Nuclear-localized, iron-bound superoxide dismutase-2 antagonizes epithelial lineage programs to promote stemness of breast cancer cells via a histone demethylase activity. Proc Natl Acad Sci U S A. 2022 Jul.119(29):e2110348119. Pubmedid: 35858297. Pmcid: PMC9303987.
• Bollu LR, Bommi PV, Monsen PJ, Zhai L, Lauing KL, Bell A, Kim M, Ladomersky E, Yang X, Platanias LC, Matei DE, Bonini MG, Munshi HG, Hashizume R, Wu JD, Zhang B, James CD, Chen P, Kocherginsky M, Horbinski C, Cameron MD, Grigorescu AA, Yamini B, Lukas RV, Schiltz GE, Wainwright DA. Identification and Characterization of a Novel Indoleamine 2,3-Dioxygenase 1 Protein Degrader for Glioblastoma. J Med Chem. 2022 Dec.65(23):15642-15662. Pubmedid: 36410047. Pmcid: PMC9743093.
• Palma FR, Ratti BA, Paviani V, Coelho DR, Miguel R, Danes JM, Zaichik SV, de Abreu AL, Silva SO, Chen Y, Silverstein RL, Karan U, Jones DP, Bonini MG. AMPK-deficiency forces metformin-challenged cancer cells to switch from carbohydrate metabolism to ketogenesis to support energy metabolism. Oncogene. 2021 Sep.40(36):5455-5467. Pubmedid: 34290400. Pmcid: PMC8669831.
• Danes JM, Palma FR, Bonini MG. Arsenic and other metals as phenotype driving electrophiles in carcinogenesis. Semin Cancer Biol. 2021 Nov.76:287-291. Pubmedid: 34563651.
• Olson J, Sheean P, Matthews L, Chitambar CR, Banerjee A, Visotcky A, Bonini M, Stolley M. Circulating miRNAs as early indicators of diet and physical activity response in women with metastatic breast cancer. Future Sci OA. 2021 Mar.7(4):FSO694. Pubmedid: 33815828. Pmcid: PMC8015665.
• Bonds JA, Shetti A, Stephen TKL, Bonini MG, Minshall RD, Lazarov O. Deficits in hippocampal neurogenesis in obesity-dependent and -independent type-2 diabetes mellitus mouse models. Sci Rep. 2020 Oct.10(1):16368. Pubmedid: 33004912. Pmcid: PMC7530538.
• Gantner BN, LaFond KM, Bonini MG. Nitric oxide in cellular adaptation and disease. Redox Biol. 2020 Jul.34:101550. Pubmedid: 32438317. Pmcid: PMC7235643.
• Lazarov O, Minshall RD, Bonini MG. Harnessing neurogenesis in the adult brain-A role in type 2 diabetes mellitus and Alzheimer's disease. Int Rev Neurobiol. 2020 Dec.155:235-269. Pubmedid: 32854856. Pmcid: PMC7687300.
• Danes JM, de Abreu ALP, Kerketta R, Huang Y, Palma FR, Gantner BN, Mathison AJ, Urrutia RA, Bonini MG. Inorganic arsenic promotes luminal to basal transition and metastasis of breast cancer. Faseb J. 2020 Dec.34(12):16034-16048. Pubmedid: 33047385. Pmcid: PMC8289339.
• McCauley MD, Hong L, Sridhar A, Menon A, Perike S, Zhang M, da Silva IB, Yan J, Bonini MG, Ai X, Rehman J, Darbar D. Ion Channel and Structural Remodeling in Obesity-Mediated Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2020 Aug.13(8):e008296. Pubmedid: 32654503. Pmcid: PMC7935016.
• Palma FR, He C, Danes JM, Paviani V, Coelho DR, Gantner BN, Bonini MG. Mitochondrial Superoxide Dismutase: What the Established, the Intriguing, and the Novel Reveal About a Key Cellular Redox Switch. Antioxid Redox Signal. 2020 Apr.32(10):701-714. Pubmedid: 31968997. Pmcid: PMC7047081.
• Bonds JA, Shetti A, Bheri A, Chen Z, Disouky A, Tai L, Mao M, Head BP, Bonini MG, Haus JM, Minshall RD, Lazarov O. Depletion of Caveolin-1 in Type 2 Diabetes Model Induces Alzheimer's Disease Pathology Precursors. J Neurosci. 2019 Oct.39(43):8576-8583. Pubmedid: 31527120. Pmcid: PMC6807274.
• He C, Danes JM, Hart PC, Zhu Y, Huang Y, de Abreu AL, O'Brien J, Mathison AJ, Tang B, Frasor JM, Wakefield LM, Ganini D, Stauder E, Zielonka J, Gantner BN, Urrutia RA, Gius D, Bonini MG. SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer. Proc Natl Acad Sci U S A. 2019 Nov.116(47):23534-23541. Pubmedid: 31591207. Pmcid: PMC6876149.
• Zhu Y, Zou X, Dean AE, Brien JO, Gao Y, Tran EL, Park SH, Liu G, Kieffer MB, Jiang H, Stauffer ME, Hart R, Quan S, Satchell KJF, Horikoshi N, Bonini M, Gius D. Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter. Nat Commun. 2019 Jun.10(1):2399. Pubmedid: 31160585. Pmcid: PMC6546705.
• Oliveira SDS, Chen J, Castellon M, Mao M, Raj JU, Comhair S, Erzurum S, Silva CLM, Machado RF, Bonini MG, Minshall RD. Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)-Dependent Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol. 2019 Jun.39(6):1191-1202. Pubmedid: 30943774. Pmcid: PMC7297129.
• Beyer AM, Bonini MG, Moslehi J. Cancer therapy-induced cardiovascular toxicity: old/new problems and old drugs. Am J Physiol Heart Circ Physiol. 2019 Jul.317(1):H164-H167. Pubmedid: 31172808. Pmcid: PMC6692734.
• Gerber TJ, Fehr VCO, Oliveira SDS, Hu G, Dull R, Bonini MG, Beck-Schimmer B, Minshall RD. Sevoflurane Promotes Bactericidal Properties of Macrophages through Enhanced Inducible Nitric Oxide Synthase Expression in Male Mice. Anesthesiology. 2019 Dec.131(6):1301-1315. Pubmedid: 31658116. Pmcid: PMC6856440.
• Lee J, Yesilkanal AE, Wynne JP, Frankenberger C, Liu J, Yan J, Elbaz M, Rabe DC, Rustandy FD, Tiwari P, Grossman EA, Hart PC, Kang C, Sanderson SM, Andrade J, Nomura DK, Bonini MG, Locasale JW, Rosner MR. Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism. Nature. 2019 Apr.568(7751):254-258. Pubmedid: 30842661. Pmcid: PMC6698916.
• Chen Z, D S Oliveira S, Zimnicka AM, Jiang Y, Sharma T, Chen S, Lazarov O, Bonini MG, Haus JM, Minshall RD. Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells. Mol Biol Cell. 2018 May.29(10):1190-1202. Pubmedid: 29563255. Pmcid: PMC5935069.
• McKeever L, Bonini M, Braunschweig C. Feeding During Phases of Altered Mitochondrial Activity: A Theory. JPEN J Parenter Enteral Nutr. 2018 Jul.42(5):855-863. Pubmedid: 30001461.
• Mey JT, Blackburn BK, Miranda ER, Chaves AB, Briller J, Bonini MG, Haus JM. Dicarbonyl stress and glyoxalase enzyme system regulation in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2018 Feb.314(2):R181-R190. Pubmedid: 29046313. Pmcid: PMC5867671.
• Bonini MG, Sargis RM. Environmental Toxicant Exposures and Type 2 Diabetes Mellitus: Two Interrelated Public Health Problems on the Rise. Curr Opin Toxicol. 2018 Feb.7:52-59. Pubmedid: 29392186. Pmcid: PMC5788318.
• Ganini D, Santos JH, Bonini MG, Mason RP. Switch of Mitochondrial Superoxide Dismutase into a Prooxidant Peroxidase in Manganese-Deficient Cells and Mice. Cell Chem Biol. 2018 Apr.25(4):413-425.e6. Pubmedid: 29398562. Pmcid: PMC5910218.
• Potje SR, Chen Z, Oliveira SDS, Bendhack LM, da Silva RS, Bonini MG, Antoniali C, Minshall RD. Nitric oxide donor [Ru(terpy)(bdq)NO]3+ induces uncoupling and phosphorylation of endothelial nitric oxide synthase promoting oxidant production. Free Radical Bio Med. 2017 Nov.112:587-596. Pubmedid: 28899725. Pmcid: PMC5647835.
• Blajszczak C, Bonini MG. Mitochondria targeting by environmental stressors: Implications for redox cellular signaling. Toxicology. 2017 Nov.391:84-89. Pubmedid: 28750850. Pmcid: PMC5939563.
• Oliveira SDS, Castellon M, Chen J, Bonini MG, Gu X, Elliott MH, Machado RF, Minshall RD. Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-β-driven pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol. 2017 May.312(5):L760-L771. Pubmedid: 28188225. Pmcid: PMC5451590.
• Rauscher GH, Silva A, Pauls H, Frasor J, Bonini MG, Hoskins K. Racial disparity in survival from estrogen and progesterone receptor-positive breast cancer: implications for reducing breast cancer mortality disparities. Breast Cancer Res Treat. 2017 Jun.163(2):321-330. Pubmedid: 28251385. Pmcid: PMC5410404.
• Ekoue DN, Bera S, Ansong E, Hart PC, Zaichick S, Domann FE, Bonini MG, Diamond AM. Allele-specific interaction between glutathione peroxidase 1 and manganese superoxide dismutase affects the levels of Bcl-2, Sirt3 and E-cadherin. Free Radic Res. 2017 Jun.51(6):582-590. Pubmedid: 28587495. Pmcid: PMC5683088.
• Ekoue DN, Zaichick S, Valyi-Nagy K, Picklo M, Lacher C, Hoskins K, Warso MA, Bonini MG, Diamond AM. Selenium levels in human breast carcinoma tissue are associated with a common polymorphism in the gene for SELENOP (Selenoprotein P). J Trace Elem Med Biol. 2017 Jan.39:227-233. Pubmedid: 27908419.
• Zou X, Ratti BA, O'Brien JG, Lautenschlager SO, Gius DR, Bonini MG, Zhu Y. Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox signaling?. J Bioenerg Biomembr. 2017 Aug.49(4):325-333. Pubmedid: 28616679.
• Ekoue DN, He C, Diamond AM, Bonini MG. Manganese superoxide dismutase and glutathione peroxidase-1 contribute to the rise and fall of mitochondrial reactive oxygen species which drive oncogenesis. Biochim Biophys Acta Bioenerg. 2017 Aug.1858(8):628-632. Pubmedid: 28087256. Pmcid: PMC5689482.
• de Abreu AL, Malaguti N, Souza RP, Uchimura NS, Ferreira ÉC, Pereira MW, Carvalho MD, Pelloso SM, Bonini MG, Gimenes F, Consolaro ME. Association of human papillomavirus, Neisseria gonorrhoeae and Chlamydia trachomatis co-infections on the risk of high-grade squamous intraepithelial cervical lesion. Am J Cancer Res. 2016 Jun.6(6):1371-1383. Pubmedid: 27429850. Pmcid: PMC4937739.
• He C, Hart PC, Germain D, Bonini MG. SOD2 and the Mitochondrial UPR: Partners Regulating Cellular Phenotypic Transitions. Trends Biochem Sci. 2016 Jul.41(7):568-577. Pubmedid: 27180143. Pmcid: PMC4930371.
• Hart PC, Ratti BA, Mao M, Ansenberger-Fricano K, Shajahan-Haq AN, Tyner AL, Minshall RD, Bonini MG. Caveolin-1 regulates cancer cell metabolism via scavenging Nrf2 and suppressing MnSOD-driven glycolysis. Oncotarget. 2016 Jan.7(1):308-322. Pubmedid: 26543228. Pmcid: PMC4808000.
• Fettiplace MR, Kowal K, Ripper R, Young A, Lis K, Rubinstein I, Bonini M, Minshall R, Weinberg G. Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion. Anesthesiology. 2016 Feb.124(2):428-442. Pubmedid: 26646023. Pmcid: PMC4718826.
• Baig MS, Zaichick SV, Mao M, de Abreu AL, Bakhshi FR, Hart PC, Saqib U, Deng J, Chatterjee S, Block ML, Vogel SM, Malik AB, Consolaro ME, Christman JW, Minshall RD, Gantner BN, Bonini MG. NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1. J Exp Med. 2015 Sep.212(10):1725-1738. Pubmedid: 26324446. Pmcid: PMC4577833.
• Taetzsch T, Levesque S, McGraw C, Brookins S, Luqa R, Bonini MG, Mason RP, Oh U, Block ML. Redox regulation of NF-κB p50 and M1 polarization in microglia. Glia. 2015 Mar.63(3):423-440. Pubmedid: 25331559. Pmcid: PMC4322433.
• Tang H, Chen J, Fraidenburg DR, Song S, Sysol JR, Drennan AR, Offermanns S, Ye RD, Bonini MG, Minshall RD, Garcia JG, Machado RF, Makino A, Yuan JX. Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2015 Jan.308(2):L208-L220. Pubmedid: 25416384. Pmcid: PMC4338938.
• Schläpfer M, Piegeler T, Dull RO, Schwartz DE, Mao M, Bonini MG, Z'Graggen BR, Beck-Schimmer B, Minshall RD. Propofol increases morbidity and mortality in a rat model of sepsis. Crit Care. 2015 Feb.19(1):45. Pubmedid: 25887642. Pmcid: PMC4344774.
• Hart PC, Mao M, de Abreu AL, Ansenberger-Fricano K, Ekoue DN, Ganini D, Kajdacsy-Balla A, Diamond AM, Minshall RD, Consolaro ME, Santos JH, Bonini MG. MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer. Nat Commun. 2015 Feb.6:6053. Pubmedid: 25651975. Pmcid: PMC4319569.
• Bera S, Weinberg F, Ekoue DN, Ansenberger-Fricano K, Mao M, Bonini MG, Diamond AM. Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function. Cancer Res. 2014 Sep.74(18):5118-5126. Pubmedid: 25047527. Pmcid: PMC4167490.
• Gong H, Gao X, Feng S, Siddiqui MR, Garcia A, Bonini MG, Komarova Y, Vogel SM, Mehta D, Malik AB. Evidence of a common mechanism of disassembly of adherens junctions through Gα13 targeting of VE-cadherin. J Exp Med. 2014 Mar.211(3):579-591. Pubmedid: 24590762. Pmcid: PMC3949568.
• Bonini MG, Consolaro MEL, Hart PC, Mao M, de Abreu ALP, Master AM. Redox control of enzymatic functions: The electronics of life's circuitry. Iubmb Life. 2014 Mar.66(3):167-181. Pubmedid: 24668617.
• Gimenes F, Medina FS, Abreu AL, Irie MM, Esquiçati IB, Malagutti N, Vasconcellos VR, Discacciati MG, Bonini MG, Maria-Engler SS, Consolaro ME. Sensitive simultaneous detection of seven sexually transmitted agents in semen by multiplex-PCR and of HPV by single PCR. PLoS One. 2014 Jun.9(6):e98862. Pubmedid: 24921247. Pmcid: PMC4055596.
• Piegeler T, Votta-Velis EG, Bakhshi FR, Mao M, Carnegie G, Bonini MG, Schwartz DE, Borgeat A, Beck-Schimmer B, Minshall RD. Endothelial barrier protection by local anesthetics: ropivacaine and lidocaine block tumor necrosis factor-α-induced endothelial cell Src activation. Anesthesiology. 2014 Jun.120(6):1414-1428. Pubmedid: 24525631. Pmcid: PMC4284094.
• Yang KC, Bonini MG, Dudley SC. Mitochondria and arrhythmias. Free Radical Bio Med. 2014 Jun.71:351-361. Pubmedid: 24713422. Pmcid: PMC4096785.
• Hecquet CM, Zhang M, Mittal M, Vogel SM, Di A, Gao X, Bonini MG, Malik AB. Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for endothelial cell apoptosis. Circ Res. 2014 Jan.114(3):469-479. Pubmedid: 24337049. Pmcid: PMC3978731.
• Gimenes F, Souza RP, Bento JC, Teixeira JJ, Maria-Engler SS, Bonini MG, Consolaro ME. Male infertility: a public health issue caused by sexually transmitted pathogens. Nat Rev Urol. 2014 Dec.11(12):672-687. Pubmedid: 25330794.
• Gimenes F, Teixeira JJ, de Abreu AL, Souza RP, Pereira MW, da Silva VR, Bôer CG, Maria-Engler SS, Bonini MG, Borelli SD, Consolaro ME. Human leukocyte antigen (HLA)-G and cervical cancer immunoediting: a candidate molecule for therapeutic intervention and prognostic biomarker?. Biochim Biophys Acta. 2014 Dec.1846(2):576-589. Pubmedid: 25453366.
• Bonini MG, Malik AB. Regulating the regulator of ROS production. Cell Res. 2014 Aug.24(8):908-909. Pubmedid: 24839902. Pmcid: PMC4123290.
• Mao M, Varadarajan S, Fukai T, Bakhshi FR, Chernaya O, Dudley SC, Minshall RD, Bonini MG. Nitroglycerin tolerance in caveolin-1 deficient mice. PLoS One. 2014 Aug.9(8):e104101. Pubmedid: 25158065. Pmcid: PMC4144835.
• Yang KC, Rutledge CA, Mao M, Bakhshi FR, Xie A, Liu H, Bonini MG, Patel HH, Minshall RD, Dudley SC. Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase. Circ Arrhythm Electrophysiol. 2014 Aug.7(4):701-710. Pubmedid: 25017399. Pmcid: PMC4198950.
• Towner RA, Smith N, Saunders D, Lupu F, Silasi-Mansat R, West M, Ramirez DC, Gomez-Mejiba SE, Bonini MG, Mason RP, Ehrenshaft M, Hensley K. In vivo detection of free radicals using molecular MRI and immuno-spin trapping in a mouse model for amyotrophic lateral sclerosis. Free Radical Bio Med. 2013 Oct.63:351-360. Pubmedid: 23722162.
• Souza RP, Gimenes F, de Abreu AL, Rocha-Brischiliari SC, de Carvalho MD, Ferreira EC, Bonini MG, Pelloso SM, Consolaro ME. Differences in the mutation of the p53 gene in exons 6 and 7 in cervical samples from HIV- and HPV-infected women. Infect Agent Cancer. 2013 Oct.8(1):38. Pubmedid: 24098975. Pmcid: PMC3851445.
• Bonini MG, Gantner BN. The multifaceted activities of AMPK in tumor progression--why the "one size fits all" definition does not fit at all?. Iubmb Life. 2013 Nov.65(11):889-896. Pubmedid: 24265196.
• Dallas S, Block ML, Thompson DM, Bonini MG, Ronaldson PT, Bendayan R, Miller DS. Microglial activation decreases retention of the protease inhibitor saquinavir: implications for HIV treatment. J Neuroinflamm. 2013 May.10:58. Pubmedid: 23642074. Pmcid: PMC3651327.
• Sovari AA, Rutledge CA, Jeong EM, Dolmatova E, Arasu D, Liu H, Vahdani N, Gu L, Zandieh S, Xiao L, Bonini MG, Duffy HS, Dudley SC. Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death. Circ Arrhythm Electrophysiol. 2013 Jun.6(3):623-631. Pubmedid: 23559673. Pmcid: PMC3716298.
• Ansenberger-Fricano K, Ganini D, Mao M, Chatterjee S, Dallas S, Mason RP, Stadler K, Santos JH, Bonini MG. The peroxidase activity of mitochondrial superoxide dismutase. Free Radical Bio Med. 2013 Jan.54:116-124. Pubmedid: 22982047. Pmcid: PMC4155036.
• Bakhshi FR, Mao M, Shajahan AN, Piegeler T, Chen Z, Chernaya O, Sharma T, Elliott WM, Szulcek R, Bogaard HJ, Comhair S, Erzurum S, van Nieuw Amerongen GP, Bonini MG, Minshall RD. Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension. Pulm Circ. 2013 Dec.3(4):816-830. Pubmedid: 25006397. Pmcid: PMC4070841.
• Souza RP, de Abreu AL, Ferreira ÉC, Rocha-Brischiliari SC, de B Carvalho MD, Pelloso SM, Bonini MG, Gimenes F, Consolaro ME. Simultaneous detection of seven sexually transmitted agents in human immunodeficiency virus-infected Brazilian women by multiplex polymerase chain reaction. Am J Trop Med Hyg. 2013 Dec.89(6):1199-1202. Pubmedid: 24080632. Pmcid: PMC3854900.
• Sieracki NA, Gantner BN, Mao M, Horner JH, Ye RD, Malik AB, Newcomb ME, Bonini MG. Bioluminescent detection of peroxynitrite with a boronic acid-caged luciferin. Free Radical Bio Med. 2013 Aug.61:40-50. Pubmedid: 23474271. Pmcid: PMC3795912.
• Schmidt TT, Tauseef M, Yue L, Bonini MG, Gothert J, Shen TL, Guan JL, Predescu S, Sadikot R, Mehta D. Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities. Am J Physiol Lung Cell Mol Physiol. 2013 Aug.305(4):L291-L300. Pubmedid: 23771883. Pmcid: PMC3891015.
• Hobbs GA, Bonini MG, Gunawardena HP, Chen X, Campbell SL. Glutathiolated Ras: characterization and implications for Ras activation. Free Radical Bio Med. 2013 Apr.57:221-229. Pubmedid: 23123410. Pmcid: PMC3985386.
• Davis MF, Zhou L, Ehrenshaft M, Ranguelova K, Gunawardena HP, Chen X, Bonini MG, Mason RP, Campbell SL. Detection of Ras GTPase protein radicals through immuno-spin trapping. Free Radical Bio Med. 2012 Sep.53(6):1339-1345. Pubmedid: 22819983. Pmcid: PMC3549333.
• Towner RA, Smith N, Saunders D, Henderson M, Downum K, Lupu F, Silasi-Mansat R, Ramirez DC, Gomez-Mejiba SE, Bonini MG, Ehrenshaft M, Mason RP. In vivo imaging of immuno-spin trapped radicals with molecular magnetic resonance imaging in a diabetic mouse model. Diabetes. 2012 Oct.61(10):2405-2413. Pubmedid: 22698922. Pmcid: PMC3447912.
• Mason RP, Ganini D, Bonini MG, Ranguelova K. Two hypotheses for the oxidation of SOD1-Cu(I). Free Radical Bio Med. 2012 Nov.53(10):1991-1992. Pubmedid: 23137624.
• Kadiiska MB, Bonini MG, Ruggiero C, Cleland E, Wicks S, Stadler K. Thiazolidinedione treatment decreases oxidative stress in spontaneously hypertensive heart failure rats through attenuation of inducible nitric oxide synthase-mediated lipid radical formation. Diabetes. 2012 Mar.61(3):586-596. Pubmedid: 22315311. Pmcid: PMC3282814.
• Mao M, Sudhahar V, Ansenberger-Fricano K, Fernandes DC, Tanaka LY, Fukai T, Laurindo FR, Mason RP, Vasquez-Vivar J, Minshall RD, Stadler K, Bonini MG. Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathway. Free Radical Bio Med. 2012 Jan.52(2):427-435. Pubmedid: 22037515. Pmcid: PMC3432314.
• Sharma NK, Reyes A, Green P, Caron MJ, Bonini MG, Gordon DM, Holt IJ, Santos JH. Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res. 2012 Jan.40(2):712-725. Pubmedid: 21937513. Pmcid: PMC3258147.
• Ranguelova K, Ganini D, Bonini MG, London RE, Mason RP. Kinetics of the oxidation of reduced Cu,Zn-superoxide dismutase by peroxymonocarbonate. Free Radical Bio Med. 2012 Aug.53(3):589-594. Pubmedid: 22569304. Pmcid: PMC3408790.
• Chen Z, Bakhshi FR, Shajahan AN, Sharma T, Mao M, Trane A, Bernatchez P, van Nieuw Amerongen GP, Bonini MG, Skidgel RA, Malik AB, Minshall RD. Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition. Mol Biol Cell. 2012 Apr.23(7):1388-1398. Pubmedid: 22323292. Pmcid: PMC3315804.
• Duma D, Fernandes D, Bonini MG, Stadler K, Mason RP, Assreuy J. NOS-1-derived NO is an essential triggering signal for the development of systemic inflammatory responses. Eur J Pharmacol. 2011 Oct.668(1-2):285-292. Pubmedid: 21651902.
• Sovari AA, Iravanian S, Dolmatova E, Jiao Z, Liu H, Zandieh S, Kumar V, Wang K, Bernstein KE, Bonini MG, Duffy HS, Dudley SC. Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death. J Am Coll Cardiol. 2011 Nov.58(22):2332-2339. Pubmedid: 22093512. Pmcid: PMC3226807.
• Siddiqui MR, Komarova YA, Vogel SM, Gao X, Bonini MG, Rajasingh J, Zhao YY, Brovkovych V, Malik AB. Caveolin-1-eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability. J Cell Biol. 2011 May.193(5):841-850. Pubmedid: 21624953. Pmcid: PMC3105546.
• Sovari AA, Bonini MG, Dudley SC. Effective antioxidant therapy for the management of arrhythmia. Expert Rev Cardiovasc Ther. 2011 Jul.9(7):797-800. Pubmedid: 21809958. Pmcid: PMC4208691.
• Toya SP, Li F, Bonini MG, Gomez I, Mao M, Bachmaier KW, Malik AB. Interaction of a specific population of human embryonic stem cell-derived progenitor cells with CD11b+ cells ameliorates sepsis-induced lung inflammatory injury. Am J Pathol. 2011 Jan.178(1):313-324. Pubmedid: 21224068. Pmcid: PMC3069906.
• Ehrenshaft M, Bonini MG, Feng L, Chignell CF, Mason RP. Partial colocalization of oxidized, N-formylkynurenine-containing proteins in mitochondria and Golgi of keratinocytes. Photochem Photobiol. 2011 Jan.86(4):752-756. Pubmedid: 20408979. Pmcid: PMC3615536.
• Hickok JR, Sahni S, Mikhed Y, Bonini MG, Thomas DD. Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron. J Biol Chem. 2011 Dec.286(48):41413-41424. Pubmedid: 21976667. Pmcid: PMC3308853.
• Chatterjee S, Lardinois O, Bhattacharjee S, Tucker J, Corbett J, Deterding L, Ehrenshaft M, Bonini MG, Mason RP. Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis. Free Radical Bio Med. 2011 Apr.50(8):988-999. Pubmedid: 21215311. Pmcid: PMC3051032.
• Ranguelova K, Bonini MG, Mason RP. (Bi)sulfite oxidation by copper, zinc-superoxide dismutase: Sulfite-derived, radical-initiated protein radical formation. Environ Health Persp. 2010 Jul.118(7):970-975. Pubmedid: 20348042. Pmcid: PMC2920917.
• Kovalenko OA, Caron MJ, Ulema P, Medrano C, Thomas AP, Kimura M, Bonini MG, Herbig U, Santos JH. A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction. Aging Cell. 2010 Apr.9(2):203-219. Pubmedid: 20089117.
• Chatterjee S, Lardinois O, Bonini MG, Bhattacharjee S, Stadler K, Corbett J, Deterding LJ, Tomer KB, Kadiiska M, Mason RP. Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis. J Immunol. 2009 Sep.183(6):4055-4066. Pubmedid: 19717511. Pmcid: PMC2804978.
• Bonini MG, Gabel SA, Ranguelova K, Stadler K, Derose EF, London RE, Mason RP. Direct magnetic resonance evidence for peroxymonocarbonate involvement in the cu,zn-superoxide dismutase peroxidase catalytic cycle. J Biol Chem. 2009 May.284(21):14618-14627. Pubmedid: 19286663. Pmcid: PMC2682909.
• Chatterjee S, Ehrenshaft M, Bhattacharjee S, Deterding LJ, Bonini MG, Corbett J, Kadiiska MB, Tomer KB, Mason RP. Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice. Free Radical Bio Med. 2009 Feb.46(4):454-461. Pubmedid: 19049863. Pmcid: PMC2661569.
• Stadler K, Bonini MG, Dallas S, Jiang J, Radi R, Mason RP, Kadiiska MB. Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes. Free Radical Bio Med. 2008 Sep.45(6):866-874. Pubmedid: 18620046. Pmcid: PMC2613788.
• Siraki AG, Deterding LJ, Bonini MG, Jiang J, Ehrenshaft M, Tomer KB, Mason RP. Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol. 2008 May.21(5):1143-1153. Pubmedid: 18489081. Pmcid: PMC2766841.
• Bonini MG, Stadler K, Silva SO, Corbett J, Dore M, Petranka J, Fernandes DC, Tanaka LY, Duma D, Laurindo FR, Mason RP. Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation. Proc Natl Acad Sci U S A. 2008 Jun.105(25):8569-8574. Pubmedid: 18562300. Pmcid: PMC2438390.
• He YY, Council SE, Feng L, Bonini MG, Chignell CF. Spatial distribution of protein damage by singlet oxygen in keratinocytes. Photochem Photobiol. 2008 Jan.84(1):69-74. Pubmedid: 18173704. Pmcid: PMC2365760.
• Stadler K, Bonini MG, Dallas S, Duma D, Mason RP, Kadiiska MB. Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis. Am J Physiol Endocrinol Metab. 2008 Aug.295(2):E456-E462. Pubmedid: 18559982. Pmcid: PMC2519762.
• Bhattacharjee S, Deterding LJ, Jiang J, Bonini MG, Tomer KB, Ramirez DC, Mason RP. Electron transfer between a tyrosyl radical and a cysteine residue in hemoproteins: spin trapping analysis. J Am Chem Soc. 2007 Nov.129(44):13493-13501. Pubmedid: 17939657.
• Raines KW, Bonini MG, Campbell SL. Nitric oxide cell signaling: S-nitrosation of Ras superfamily GTPases. Cardiovasc Res. 2007 Jul.75(2):229-239. Pubmedid: 17559822.
• Siraki AG, Bonini MG, Jiang J, Ehrenshaft M, Mason RP. Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol. 2007 Jul.20(7):1038-1045. Pubmedid: 17602675. Pmcid: PMC2073000.
• Bonini MG, Siraki AG, Atanassov BS, Mason RP. Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes. Free Radical Bio Med. 2007 Feb.42(4):530-540. Pubmedid: 17275685. Pmcid: PMC1952183.
• Bonini MG, Siraki AG, Bhattacharjee S, Mason RP. Glutathione-induced radical formation on lactoperoxidase does not correlate with the enzyme's peroxidase activity. Free Radical Bio Med. 2007 Apr.42(7):985-992. Pubmedid: 17349926. Pmcid: PMC1994934.
• Bonini MG, Rota C, Tomasi A, Mason RP. The oxidation of 2',7'-dichlorofluorescin to reactive oxygen species: a self-fulfilling prophesy?. Free Radical Bio Med. 2006 Mar.40(6):968-975. Pubmedid: 16540392.
• Lima ES, Bonini MG, Augusto O, Barbeiro HV, Souza HP, Abdalla DS. Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxation. Free Radical Bio Med. 2005 Aug.39(4):532-539. Pubmedid: 16043024.
• Augusto O, Bonini MG, Trindade D. Spin trapping of glutathiyl and protein radicals produced from nitric oxide-derived oxidants. Free Radical Bio Med. 2004 May.36(10):1224-1232. Pubmedid: 15110387.
• Bonini MG, Fernandes DC, Augusto O. Albumin oxidation to diverse radicals by the peroxidase activity of Cu,Zn-superoxide dismutase in the presence of bicarbonate or nitrite: diffusible radicals produce cysteinyl and solvent-exposed and -unexposed tyrosyl radicals. Biochemistry-Us. 2004 Jan.43(2):344-351. Pubmedid: 14717588.
• Bonini MG, Miyamoto S, Di Mascio P, Augusto O. Production of the carbonate radical anion during xanthine oxidase turnover in the presence of bicarbonate. J Biol Chem. 2004 Dec.279(50):51836-51843. Pubmedid: 15448145.
• Augusto O, Bonini MG, Amanso AM, Linares E, Santos CC, De Menezes SL. Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology. Free Radical Bio Med. 2002 May.32(9):841-859. Pubmedid: 11978486.
• Bonini MG, Mason RP, Augusto O. The Mechanism by which 4-hydroxy-2,2,6,6-tetramethylpiperidene-1-oxyl (tempol) diverts peroxynitrite decomposition from nitrating to nitrosating species. Chem Res Toxicol. 2002 Apr.15(4):506-511. Pubmedid: 11952336.

• Title: A redox-sensitive switch in the macrophage nucleus regulates acute phase inflammatory injury
  Award Number: 7R01HL163820-04
  Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
  Bonini, M. (PD/PI)
• Title: Repurposing pantothenate kinase modulators for the treatment of aggressive sugar-addicted cancers.
  Award Number: 26C02
  Sponsor: Florida Department of Health
  Bonini, M. (PD/PI)
• Title: Suppression of progesterone receptor signaling by heavy metals promotes tamoxifen resistance and metastasis or ER+ breast cancer
  Award Number: 7R01ES035353
  Sponsor: National Institute of Environmental Health Sciences (NIEHS)
  Bonini, M. (PD/PI)
• Title: H3 histone oxidation is a new posttranslational modification linking heavy metal-induced metabolic changes and oncegenic epigenetic reprogramming
  Award Number: 5R01ES035723-04
  Sponsor: National Institute of Environmental Health Sciences (NIEHS)
  Bonini, M. (PD/PI)
• Title: Every Day Counts: A lifestyle program for women with metastatic breast cancer
  Award Number: 5R01CA258759-05
  Sponsor: National Institutes of Health (NIH)
  Bonini, M. (PD/PI)
• Title: Leveraging metabolic vulnerabilities of uveal melanoma for increased sensitivity to targeted alpha-particle therapy
  Award Number: 02300002609
  Sponsor: Moffitt Cancer Center
  Morse, D. (PD/PI), Bonini, M. (Co-PD/PI)