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Pancreatic cancer can be difficult to detect in its early stages. Around half of all pancreatic cancers are diagnosed in Stage 4, when the cancer has spread to other organs. The pancreas is located deep within the abdomen, and early pancreatic cancer often causes vague symptoms that can be easy to overlook. In some cases, noticeable symptoms may not appear until the disease has progressed.

Knowing the potential warning signs of pancreatic cancer can help you recognize changes in your health and know when to talk with a doctor.

check mark symbol Medically reviewed by Sarah Hoffe, MD, Gastrointestinal Oncology Program

What are the early signs of pancreatic cancer?


The signs and symptoms of pancreatic cancer can vary from person to person. Some of the more common symptoms include:

Jaundice. Jaundice, or yellowing of the skin and whites of the eyes, can be one of the first noticeable signs of pancreatic cancer. It can occur when a tumor blocks the common bile duct, causing bilirubin to build up in the body.

Jaundice can also cause other changes, including dark-colored urine, light-colored stools and greasy stools. However, jaundice has many possible causes other than pancreatic cancer, including gallstones, hepatitis and other conditions affecting the liver and bile ducts. These conditions are much more common than cancer.

Abdominal or back pain. Pancreatic cancer can cause pain in the abdomen or back. A tumor may press on nearby organs or nerves, resulting in discomfort. Depending on the tumor’s location, abdominal pain may travel toward the back.

Unexplained weight loss. Unintentional weight loss can be a sign of pancreatic cancer. A pancreatic tumor may cause a loss of appetite or a feeling of fullness, which can make it difficult to eat enough to maintain weight.

Digestive problems. Because the pancreas plays an important role in digestion, pancreatic cancer can cause digestive changes. Possible symptoms include indigestion, nausea, vomiting and diarrhea. Some people may also experience changes in their stools.

These symptoms are common and can have many causes, so experiencing digestive problems does not necessarily mean that someone has pancreatic cancer.

New or worsening diabetes. Changes in blood sugar can sometimes be associated with pancreatic cancer. A tumor can affect the insulin-producing cells of the pancreas, potentially resulting in high blood sugar or diabetes.

For people who already have diabetes, pancreatic cancer may also be associated with worsening blood sugar control.

Fatigue. Unexplained fatigue or weakness can occur with pancreatic cancer, although fatigue is a common symptom of many other health conditions as well.

Pancreatic cancer symptoms can be easy to overlook. Abdominal discomfort, digestive changes, fatigue or changes in blood sugar can have many causes. If something is new or unusual for you, it’s worth talking worth talking with your doctor.

Why is Pancreatic Cancer Difficult to Detect Early?

One of the challenges of detecting pancreatic cancer is that its symptoms can be vague or subtle. Because early pancreatic cancer may cause few noticeable symptoms, it can be difficult to identify before it has progressed.

There is also no standard screening test recommended for people who are not showing signs of pancreatic cancer. However, some people at increased risk, including those with a family history of pancreatic cancer or certain types of hereditary or chronic pancreatitis, may benefit from regular monitoring.

When should you talk to your doctor about pancreatic cancer symptoms?


Many of the symptoms associated with pancreatic cancer can also be caused by conditions that are much more common. Having one or more of these symptoms does not necessarily mean you have pancreatic cancer.

However, it is important to pay attention to changes that are new or unusual for you. If you experience unexplained symptoms or changes that persist, talk with your doctor. Your physician can evaluate your symptoms, medical history and risk factors and determine whether additional testing is appropriate.

Understanding your risk  

Some individuals may have a higher risk of developing pancreatic cancer. Family history and certain hereditary conditions can increase risk, as can chronic or hereditary pancreatitis.

Based on your individual risk factors, your doctor can determine whether specialized screening or monitoring may be appropriate. If screening or monitoring is recommended, Moffitt’s Pancreas Interception Center provides specialized care for individuals who may be at increased risk of developing pancreatic cancer.

Some patients may also have benign pancreatic cysts that need to be monitored because some cysts can change over time. Experts at the Pancreas Interception Center can help determine an individual’s risk and develop an appropriate screening program to monitor for changes.

National Pancreas Foundation Center of Excellence

Pancreatic Cancer Center of Excellence

Moffitt is recognized as a National Pancreas Foundation Center of Excellence focusing on the multispecialty treatment of pancreatic cancer, treating each patient with a focus on the best possible outcomes and improved quality of life.

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Take the next step 

Pancreatic cancer can be challenging to detect early, but understanding the potential warning signs can help you recognize changes that warrant medical attention. Pay attention to what is normal for you and talk with your doctor about any new or unexplained symptoms or changes in your health.

If you have symptoms that may be associated with pancreatic cancer or concerns about your risk, Moffitt Cancer Centers Gastrointestinal Oncology Program can help.

Our team of experts provides comprehensive diagnostic and treatment services for patients with pancreatic cancer. You can request an appointment by calling 888-663-3488 or by submitting a new patient registration form online. Referrals are not required.