Heiko Enderling, PhD
Researcher

Heiko Enderling, PhD

Academic Rank: Associate Member

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Overview

Discipline

    • Integrated Mathematical Oncology
    • Radiation Oncology
    • Cancer Biology and Evolution Program

Education & Training

    • University of Dundee, PhD - Mathematical Biology
    • University of Dundee, Postdoctoral Researcher - Mathematics, Surgery, Molecular Oncology
    • Tufts University School of Medicine, Postdoctoral Fellow
Research

Dr. Enderling's research interests are focused on developing clinically and experimentally motivated and quantitative models of cell-cell interactions within a tumor as well as at the tumor-host interface. In particular, the work in his laboratory focuses on the role of cancer stem cells in tumor progression and treatment response, with the ultimate goal to improve patient-specific treatment design.

Publications

  • Caudell JJ, Torres-Roca JF, Gillies RJ, Enderling H, Kim S, Rishi A, Moros EG, Harrison LB. The future of personalised radiotherapy for head and neck cancer. Lancet Oncol. 2017 May;18(5):e266-e273. Pubmedid: 28456586.
  • Poleszczuk J, Luddy K, Chen L, Lee JK, Harrison LB, Czerniecki BJ, Soliman H, Enderling H. Neoadjuvant radiotherapy of early-stage breast cancer and long-term disease-free survival. Breast Cancer Res. 2017 Jun;19(1):75. Pubmedid: 28666457. Pmcid: PMC5493088.
  • Walker R, Poleszczuk J, Mejia J, Lee JK, Pimiento JM, Malafa M, Giuliano AR, Enderling H, Coppola D. Toward early detection of Helicobacter pylori-associated gastric cancer. Gastric Cancer. 2017 Jul. Pubmedid: 28725964.
  • Poleszczuk J, Walker R, Moros EG, Latifi K, Caudell JJ, Enderling H. Predicting Patient-Specific Radiotherapy Protocols Based on Mathematical Model Choice for Proliferation Saturation Index. Bull Math Biol. 2017 Jul. Pubmedid: 28681150.
  • Sasi SP, Yan X, Zuriaga-Herrero M, Gee H, Lee J, Mehrzad R, Song J, Onufrak J, Morgan J, Enderling H, Walsh K, Kishore R, Goukassian DA. Different Sequences of Fractionated Low-Dose Proton and Single Iron-Radiation-Induced Divergent Biological Responses in the Heart. Radiat Res. 2017 Aug;188(2):191-203. Pubmedid: 28613990.
  • Shiao JC, Mohamed ASR, Messer JA, Hutcheson KA, Johnson JM, Enderling H, Kamal M, Warren BW, Pham B, Morrison WH, Zafereo ME, Hessel AC, Lai SY, Kies MS, Ferrarotto R, Garden AS, Schomer DF, Gunn GB, Phan J, Frank SJ, Beadle BM, Weber RS, Lewin JS, Rosenthal DI, Fuller CD. Quantitative pretreatment CT volumetry: Association with oncologic outcomes in patients with T4a squamous carcinoma of the larynx. Head Neck. 2017 Aug;39(8):1609-1620. Pubmedid: 28464542. Pmcid: PMC5511768.
  • Santiago DN, Heidbuechel JPW, Kandell WM, Walker R, Djeu J, Engeland CE, Abate-Daga D, Enderling H. Fighting Cancer with Mathematics and Viruses. Viruses. 2017 Aug;9(9). Pubmedid: 28832539.
  • Poleszczuk J, Luddy KA, Prokopiou S, Robertson-Tessi M, Moros EG, Fishman M, Djeu JY, Finkelstein SE, Enderling H. Abscopal Benefits of Localized Radiotherapy Depend on Activated T-cell Trafficking and Distribution between Metastatic Lesions. Cancer Res. 2016 Mar;76(5):1009-1018. Pubmedid: 26833128.
  • Poleszczuk J, Enderling H. Cancer Stem Cell Plasticity as Tumor Growth Promoter and Catalyst of Population Collapse. Stem Cells Int. 2016 Feb;2016:3923527. Pubmedid: 26858759. Pmcid: PMC4686719.
  • Sasi SP, Park D, Muralidharan S, Wage J, Kiladjian A, Onufrak J, Enderling H, Yan X, Goukassian DA. Corrigendum to "Particle Radiation-Induced Nontargeted Effects in Bone-Marrow-Derived Endothelial Progenitor Cells". Stem Cells Int. 2016 Feb;2016:7958361. Pubmedid: 26880990. Pmcid: PMC4736558.
  • Perni S, Mohamed AS, Scott J, Enderling H, Garden AS, Gunn GB, Rosenthal DI, Fuller CD. CT-based volumetric tumor growth velocity: A novel imaging prognostic indicator in oropharyngeal cancer patients receiving radiotherapy. Oral Oncol. 2016 Dec;63:16-22. Pubmedid: 27938995. Pmcid: PMC5157841.
  • Walker R, Enderling H. From concept to clinic: Mathematically informed immunotherapy. Curr Prob Cancer. 2016 Dec;40(1):68-83. Pubmedid: 26645497.
  • Poleszczuk JT, Johnstone PA, Enderling H. Stratifying prostate cancer patients by relative lymph node involvement: population- and modeling-based study. Cancer Med. 2016 Aug;5(8):1850-1855. Pubmedid: 27227813. Pmcid: PMC4884636.
  • Poleszczuk J, Macklin P, Enderling H. Agent-Based Modeling of Cancer Stem Cell Driven Solid Tumor Growth. Methods Mol Biol. 2016;1516:335-346. Pubmedid: 27044046.
  • Sasi SP, Song J, Park D, Enderling H, McDonald JT, Gee H, Garrity B, Shtifman A, Yan X, Walsh K, Natarajan M, Kishore R, Goukassian DA. TNF-TNFR2/p75 signaling inhibits early and increases delayed nontargeted effects in bone marrow-derived endothelial progenitor cells. J Biol Chem. 2015 Nov;290(45):27014. Pubmedid: 26546693. Pmcid: PMC4646378.
  • Poleszczuk J, Hahnfeldt P, Enderling H. Therapeutic implications from sensitivity analysis of tumor angiogenesis models. PLoS One. 2015 Mar;10(3):e0120007. Pubmedid: 25785600. Pmcid: PMC4364928.
  • Poleszczuk J, Hahnfeldt P, Enderling H. Evolution and phenotypic selection of cancer stem cells. PLoS Comput Biol. 2015 Mar;11(3):e1004025. Pubmedid: 25742563. Pmcid: PMC4351192.
  • Johnstone PA, Enderling H. Mathematical Modeling of Acupuncture as Cancer Symptom Therapy: First Steps. J Acupunct Meridian Stud. 2015 Jun;8(3):113-114. Pubmedid: 26100063.
  • Prokopiou S, Moros EG, Poleszczuk J, Caudell J, Torres-Roca JF, Latifi K, Lee JK, Myerson R, Harrison LB, Enderling H. A proliferation saturation index to predict radiation response and personalize radiotherapy fractionation. Radiat Oncol. 2015 Jul;10:159. Pubmedid: 26227259. Pmcid: PMC4521490.
  • Enderling H. Cancer stem cells: small subpopulation or evolving fraction?. Integr Biol (Camb). 2015 Jan;7(1):14-23. Pubmedid: 25359461.
  • Yan X, Sasi SP, Gee H, Lee J, Yang Y, Mehrzad R, Onufrak J, Song J, Enderling H, Agarwal A, Rahimi L, Morgan J, Wilson PF, Carrozza J, Walsh K, Kishore R, Goukassian DA. Correction: Cardiovascular Risks Associated with Low Dose Ionizing Particle Radiation. PLoS One. 2015;10(11):e0142764. Pubmedid: 26544605. Pmcid: PMC4636225.
  • Sasi SP, Bae S, Song J, Perepletchikov A, Schneider D, Carrozza J, Yan X, Kishore R, Enderling H, Goukassian DA. Correction: Therapeutic Non-Toxic Doses of TNF Induce Significant Regression in TNFR2-p75 Knockdown Lewis Lung Carcinoma Tumor Implants. PLoS One. 2015;10(11):e0144213. Pubmedid: 26619137. Pmcid: PMC4664239.
  • Yan X, Sasi SP, Gee H, Lee J, Yang Y, Mehrzad R, Onufrak J, Song J, Enderling H, Agarwal A, Rahimi L, Morgan J, Wilson PF, Carrozza J, Walsh K, Kishore R, Goukassian DA. Cardiovascular risks associated with low dose ionizing particle radiation. PLoS One. 2014 Oct;9(10):e110269. Pubmedid: 25337914. Pmcid: PMC4206415.
  • P Sasi S, Song J, Park D, Enderling H, McDonald JT, Gee H, Garrity B, Shtifman A, Yan X, Walsh K, Natarajan M, Kishore R, Goukassian DA. TNF-TNFR2/p75 signaling inhibits early and increases delayed nontargeted effects in bone marrow-derived endothelial progenitor cells. J Biol Chem. 2014 May;289(20):14178-14193. Pubmedid: 24711449. Pmcid: PMC4022885.
  • Sasi SP, Bae S, Song J, Perepletchikov A, Schneider D, Carrozza J, Yan X, Kishore R, Enderling H, Goukassian DA. Therapeutic non-toxic doses of TNF induce significant regression in TNFR2-p75 knockdown Lewis lung carcinoma tumor implants. PLoS One. 2014 Mar;9(3):e92373. Pubmedid: 24664144. Pmcid: PMC3963887.
  • Sasi SP, Song J, Enderling H, Yan X, Goukassian DA. TNF-α and IL-1α but not MCP-1 and Rantes increase significantly the formation of p-H2AX foci in naive BM-derived TNFR1/p55KO EPCs. J Radiat Res. 2014 Mar;55 Suppl 1:i122-i123. Pmcid: PMC3941533.
  • Weekes SL, Barker B, Bober S, Cisneros K, Cline J, Thompson A, Hlatky L, Hahnfeldt P, Enderling H. A multicompartment mathematical model of cancer stem cell-driven tumor growth dynamics. Bull Math Biol. 2014 Jul;76(7):1762-1782. Pubmedid: 24840956. Pmcid: PMC4140966.
  • Poleszczuk J, Enderling H. A High-Performance Cellular Automaton Model of Tumor Growth with Dynamically Growing Domains. Appl Math (Irvine). 2014 Jan;5(1):144-152. Pubmedid: 25346862. Pmcid: PMC4208695.
  • Enderling H, Chaplain MA. Mathematical modeling of tumor growth and treatment. Curr Pharm Des. 2014 Aug;20(30):4934-4940. Pubmedid: 24283955.
  • Enderling H, Rejniak KA. Simulating cancer: computational models in oncology. Front Oncol. 2013 Sep;3:233. Pubmedid: 24062986. Pmcid: PMC3772565.
  • McGuire MF, Enderling H, Wallace DI, Batra JS, Jordan M, Kumar S, Panetta JC, Pasquier E. Formalizing an integrative, multidisciplinary cancer therapy discovery workflow. Cancer Res. 2013 Oct;73(20):6111-6117. Pubmedid: 23955390. Pmcid: PMC4040396.
  • Enderling H. Unveiling stem cell kinetics: prime time for integrating experimental and computational models. Front Oncol. 2013 Nov;3:291. Pubmedid: 24350056. Pmcid: PMC3842622.
  • Gao X, McDonald JT, Hlatky L, Enderling H. Acute and fractionated irradiation differentially modulate glioma stem cell division kinetics. Cancer Res. 2013 Mar;73(5):1481-1490. Pubmedid: 23269274. Pmcid: PMC3594421.
  • Hillen T, Enderling H, Hahnfeldt P. The tumor growth paradox and immune system-mediated selection for cancer stem cells. Bull Math Biol. 2012 Dec;75(1):161-184. Pubmedid: 23196354.
  • Enderling H, Hlatky L, Hahnfeldt P. Immunoediting: evidence of the multifaceted role of the immune system in self-metastatic tumor growth. Theor Biol Med Model. 2013 Apr;9:31. Pubmedid: 22838395. Pmcid: PMC3499182.
  • Enderling H. Cancer stem cells and tumor dormancy. Adv Exp Med Biol. 2013 Apr;734:55-71. Pubmedid: 23143975.
  • Enderling H, Hlatky L, Hahnfeldt P. Cancer Stem Cells: A Minor Cancer Subpopulation that Redefines Global Cancer Features. Front Oncol. 2013 Apr;3:76. Pubmedid: 23596563. Pmcid: PMC3625721.
  • Sasi SP, Yan X, Enderling H, Park D, Gilbert HY, Curry C, Coleman C, Hlatky L, Qin G, Kishore R, Goukassian DA. Breaking the 'harmony' of TNF-α signaling for cancer treatment. Oncogene. 2012 Sep;31(37):4117-4127. Pubmedid: 22158049.
  • Enderling H, Hahnfeldt P, Hlatky L, Almog N. Systems biology of tumor dormancy: linking biology and mathematics on multiple scales to improve cancer therapy. Cancer Res. 2012 May;72(9):2172-2175. Pubmedid: 22414579. Pmcid: PMC3374524.
  • Enderling H, Hlatky L, Hahnfeldt P. The promoting role of a tumour-secreted chemorepellent in self-metastatic tumour progression. Math Med Biol. 2012 Jul;29(1):21-29. Pubmedid: 20929852.
  • Morton CI, Hlatky L, Hahnfeldt P, Enderling H. Non-stem cancer cell kinetics modulate solid tumor progression. Theor Biol Med Model. 2011 Dec;8:48. Pubmedid: 22208390. Pmcid: PMC3285090.
  • Enderling H, Hahnfeldt P. Cancer stem cells in solid tumors: is 'evading apoptosis' a hallmark of cancer?. Prog Biophys Mol Biol. 2011 Dec;106(2):391-399. Pubmedid: 21473880.
  • Tang J, Enderling H, Becker-Weimann S, Pham C, Polyzos A, Chen CY, Costes SV. Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling. Integr Biol (Camb). 2011 Apr;3(4):408-421. Pubmedid: 21373705. Pmcid: PMC4009383.
  • Enderling H, Hlatky L, Hahnfeldt P. Tumor morphological evolution: directed migration and gain and loss of the self-metastatic phenotype. Biol Direct. 2010 Jul;5:23. Pubmedid: 20406441. Pmcid: PMC2868833.
  • Enderling H, Chaplain MA, Hahnfeldt P. Quantitative modeling of tumor dynamics and radiotherapy. Acta Biotheor. 2010 Dec;58(4):341-353. Pubmedid: 20658170.
  • Enderling H, Anderson AR, Chaplain MA, Beheshti A, Hlatky L, Hahnfeldt P. Paradoxical dependencies of tumor dormancy and progression on basic cell kinetics. Cancer Res. 2009 Nov;69(22):8814-8821. Pubmedid: 19887613.
  • Enderling H, Hlatky L, Hahnfeldt P. Migration rules: tumours are conglomerates of self-metastases. Br J Cancer. 2009 Jul;100(12):1917-1925. Pubmedid: 19455139. Pmcid: PMC2714240.
  • Enderling H, Alexander NR, Clark ES, Branch KM, Estrada L, Crooke C, JourquinJ, Lobdell N, Zaman MH, Guelcher SA, Anderson AR, Weaver AM. Dependence of invadopodia function on collagen fiber spacing and cross-linking: computational modeling and experimental evidence. Biophys J. 2008 Sep;95(5):2203-2218. Pubmedid: 18515372. Pmcid: PMC2517013.
  • Enderling H, Chaplain M, Anderson A, Vaidya J. A mathematical model of breast cancer development, local treatment and recurrence. J Theor Biol. 2007 May;246(2):245-259. Pubmedid: 17289081.
  • Enderling H, Anderson AR, Chaplain MA, Rowe GW. Visualisation of the numerical solution of partial differential equation systems in three space dimensions and its importance for mathematical models in biology. Math Biosci Eng. 2006 Oct;3(4):571-582. Pubmedid: 20361833.
  • Enderling H, Anderson A, Chaplain M, Munro A, Vaidya J. Mathematical modelling of radiotherapy strategies for early breast cancer. J Theor Biol. 2006 Jul;241(1):158-171. Pubmedid: 16386275.